HOME >> BIOLOGY >> NEWS
NRH1 and Wnt signaling come together in convergent extension

ral plate marker gene expression to converge on the midline or extend axially. Interestingly, interfering with NRH1 function by introducing morpholinos to block production of the NRH1 protein had similar effects the inhibition of convergent extension. That both gain and loss of NRH1 function resulted in the failure of CE activity suggested that the gene's function in this process is tightly regulated.

These first findings led Sasai to investigate possible interactions between NRH1 and genes involved in the Wnt/PCP (planar cell polarity) signaling pathway, which is also known to play an important role in the regulation of CE movements in both fish and frog through the activity of downstream small GTPases. This protein family, which includes Rho, Rac and Cdc42, interacts with the cytoskeleton and plays important roles in the dynamics of cell morphology and motility. Overexpression and loss-of-function of NRH1 in the marginal zone (where convergent extension originates) respectively resulted in increased and decreased Rho, Rac and Cdc42 activity, confirming the link between NRH1 and Rho-family small GTPases. Loss of NRH1 function could be rescued by the co-injection of Frz7, a Wnt receptor functioning upstream of Rho, Rac and Cdc42 in the PCP pathway and, similarly, NRH1 complemented a dominant-negative Frz7 phenotype, indicating the two proteins play compensatory and mutually independent roles in the activation of small GTPases.

Further experiments showed that NRH1's effects on CE movements are also mediated by a second branch of the Wnt/PCP pathway, in which MKK7 and JNK work to phosphorylate c-Jun in the animal cap (a region of prospective ectoderm located on the roof of the blastocoel, a hollow in the spherical early embryo). As with the small GTPases, the activation of the MKK7-JNK cascade could also be effected by either Frz7 or NRH1, but it was found that NRH1 functioned independently of Xdsh, another upstream regulator of Rho-family small GTP
'"/>

Contact: Doug Sipp
sipp@cdb.riken.jp
81-78-306-3043
RIKEN Center for Developmental Biology
20-Jul-2004


Page: 1 2 3

Related biology news :

1. Activated signaling pathway may predict lung cancer patients response to gefitinib
2. From lung to gut the Wnt signaling pathway transforms cell fate
3. Equine clonings triple play sheds light on calcium, cell signaling, human disease
4. UT Southwestern researchers learn importance of insulin family signaling in male sex determination
5. Mantis shrimp fluoresce to enhance signaling in the dim ocean depths
6. OHSU researchers discover molecular signaling system controlling aspects of embryonic development
7. New study identifies gene signaling puberty
8. Are the bright colors of some avian eggs signaling female genetic quality to their mates?
9. Scientists map signaling molecule crucial to survival, disease
10. Researchers identify molecular signaling system that is crucial for plant fertility
11. Plants and people share a molecular signaling system, researchers discover

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: NRH1 and Wnt signaling come together convergent extension

(Date:5/25/2015)... SYDNEY , May 25, 2015  Australia,s market ... inception stage, although 2014 saw the advent of several ... on 24 April 2015 is expected to ignite interest ... devices in Australia . This in ... the industry and drive new partnerships amongst vendors and ...
(Date:5/20/2015)... , May 20, 2015 ... ) has announced the addition of ... Global Iris Recognition Market"  report to ... ,This research service analyses trends in ... government and commercial sectors, globally. Despite ...
(Date:5/18/2015)... Sweden , May 18, 2015 ... fingerprint sensors FPC1020, FPC1025, FPC1145, FPC1155 and FPC1035 from one ... from June until and including Q3 2015 and the sensors ... . Communicated order values for 2015 hereby amount to ... for Q1 2015 of 140 MSEK and a number of ...
Breaking Biology News(10 mins):Australian wearables market to grow at CAGR of 78%; revenue of A$1 billion by 2018, says Frost & Sullivan 2Australian wearables market to grow at CAGR of 78%; revenue of A$1 billion by 2018, says Frost & Sullivan 3Australian wearables market to grow at CAGR of 78%; revenue of A$1 billion by 2018, says Frost & Sullivan 4Global Iris Recognition Market Report 2015 - 5-Year Opportunity Analysis 2Fingerprint Cards Receives Touch Fingerprint Sensor Order of SEK 230 Million and Raises Revenue Guidance for 2015 2
(Date:5/27/2015)... The Medical Innovation Impact Index (MI3), a ... medical innovation, has been developed at the Initiative ... University’s ( FDU ) Rothman Institute of Innovation and ... new FDA (Food & Drug Administration) draft guidance documents ... certain medical devices. , “The main impediment to ...
(Date:5/26/2015)... 26, 2015 Innovacyn, a leader ... the human and animal health industries, announced today ... Innovators of Agriculture College Scholarship Award. The scholarship ... exhibits a passionate commitment to the agriculture industry ... year’s winners, Alexis Pedrow from Anderson County Jr/Sr ...
(Date:5/26/2015)... 2015  Alere Inc. (NYSE: ALR ) (the "Company") ... timely file its Quarterly Report on Form 10-Q for the ... has received a notice from the New York Stock Exchange ... the NYSE,s continued listing requirements under the timely filing criteria ... The reason for the delay relates to ...
(Date:5/26/2015)... , May 26, 2015  A simple blood ... Science Center to detect early Alzheimer,s disease is a ... Detailed standardized guidelines that are needed before ... been published in Alzheimer,s & Dementia . The ... an international working group that includes UNT Health Science ...
Breaking Biology Technology:Medical Innovation Impact Index Launched at Fairleigh Dickinson University’s Initiative for Patient-Centered Innovation (iPCI) under the Rothman Institute 2Innovacyn Announces Winners Of This Year’s Vetericyn® College Scholarship Award 2Innovacyn Announces Winners Of This Year’s Vetericyn® College Scholarship Award 3Guidelines bring UNT Health Science Center's blood test for Alzheimer's one step closer 2
Cached News: