NYU And Rockefeller Scientists Design Molecules That Stymie A Notorious Bug

NEW YORK, Feb. 15, 1999 -- Scientists at New York University School of Medicine and The Rockefeller University have discovered the structure of a key compound that enables a dangerous bug to cause devastating infections. They have also designed molecules that block the compound's effects, opening a novel way to combat these infections.

The scientists, led by NYU's Richard Novick, M.D., and Rockefeller's Tom Muir, Ph.D., found that an unusual peptide compound activates the disease-causing mechanism of Staphylococcus aureus, a notorious bacterium that each year infects some 500,000 hospitalized patients. By substituting parts of the compound with different chemicals, the researchers created compounds that dramatically weakened Staph infections in mice, according to a joint study published in the Feb. 16 issue of the Proceedings of the National Academy of Sciences.

"One of our long-term goals is to develop novel therapies to combat Staph," says Dr. Novick, Professor of Microbiology and Medicine at NYU School of Medicine. "Our study is extremely significant in that regard because it demonstrates the feasibility of constructing synthetic analogues that turn off Staph's ability to cause infection while leaving the bacterium intact. This may provide a way to get around the problem of antibiotic resistance because our analogues don't kill bacteria," he says.

Staphylococcus aureus causes a wide range of illnesses, from relatively minor skin abscesses to life-threatening toxic shock syndrome and other illnesses. Antibiotics kill the bacterium, but in recent years the wily bug increasingly has become resistant to the most commonly used antibiotics. The development of antibiotic-resistant strains of Staph and other bacteria has caused widespread alarm that one day there may be many so-called superbugs resistant to all known antibiotics.

Several years ago, Dr. Novick's laboratory discovered that a master gene, or glob

Contact: Lynn Odell or Joe Bonner
New York University Medical Center and School of Medicine

Page: 1 2

Related biology news :

1. Rockefeller University scientists take on controversial vibration theory of smell
2. By the year 2050, human population could add 2.6 billion people, reports Rockefeller scientist
3. White House awards National Medal of Science to Rockefeller Universitys James Darnell
4. Lasker Award honors Rockefeller University biochemist for pioneering studies of gene activation
5. Rockefeller scientists identify natural proteins that push stem cells to produce hair, not skin
6. Rockefeller, Weill Cornell researchers find link between estrogen, brain structure changes
7. Rockefeller researchers provide the first functional evidence for mammalian pheromone receptors
8. Another transmembrane protein structure solved by Rockefeller scientists
9. Rockefeller researchers identify defense system in plants
10. Rockefeller University Centennial Symposium to explore biology of drug abuse and addiction
11. Rockefeller University researchers discover immune-cell mechanism that boosts therapeutic antibody potency

Post Your Comments:

(Date:9/25/2019)... ... September 25, 2019 , ... LeadingBiotech , ... dialogue, today announces its inaugural South CEO conference to be held ... , Co-produced by Tulane University, this invitation-only meeting convenes biopharma executives to discuss ...
(Date:9/24/2019)... (PRWEB) , ... September 24, 2019 , ... ... its technology driven portfolio of 3D porous titanium spinal implants with the expansion ... Ti3D implant offerings while more than tripling the number of cervical and lumbar ...
(Date:9/22/2019)... ... September 20, 2019 , ... ... are adjusting to client demands for precision medicine products. The report, Lab ... $19 billion in 2018, the pharma/bio sector is the largest source of demand ...
Breaking Biology News(10 mins):
(Date:10/8/2019)... , ... October 08, 2019 , ... ... (TMP), Madhumita Suresh and Leslie Maurer presented company executives with a set of ... Science (MBS) graduates will offer insights from their TMP to a wider audience ...
(Date:10/3/2019)... ... October 01, 2019 , ... ... and reset itself, announced the midway point of its randomized research trial for ... study is to measure the efficacy of a non-invasive technology which compares tones ...
(Date:10/3/2019)... Calif. (PRWEB) , ... October 02, 2019 , ... ... business opportunity to investors and venture capital companies in Silicon Valley at a special ... 8:30 pm. The event will be held at the JJ Lake Business Center located ...
(Date:10/3/2019)... ... October 03, 2019 , ... Yesterday, at the 2019 meeting of ... and director, James L. Sherley, M.D., Ph.D., discussed important design factors that currently limit ... including both developers and suppliers of clinical trials, in his talk Dr. ...
Breaking Biology Technology:
Cached News: