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NYU Researchers Develop Simple, Predictable And Precise Technique For Arranging,,DNA Molecules Into Two-Dimensional Crystals

its possessed modifications visible as stripes. The other set had an A-B-C-D structure, where only the D units possessed the modifications. Both sets had evenly-spaced stripes at predicted separations; the stripes in the A-B-C-D structure were twice as far apart as in the A-B structure, demonstrating the accuracy of the molecular recognition.

The authors of the Nature article, entitled "Design and self-assembly of two-dimensional DNA crystals" are as follows: Erik Winfree, Computation and Neural Systems, California Institute of Technology; Furong Liu, NYU Department of Chemistry; Lisa A. Wenzler, NYU Department of Chemistry; and Nadrian C. Seeman, NYU Department of Chemistry.

Nadrian C. Seeman was born in Chicago in 1945. Following a BS in biochemistry from the University of Chicago, he received his Ph.D. in biological crystallography from the University of Pittsburgh in 1970. His postdoctoral training, at Columbia and MIT, emphasized nucleic acid crystallography. He obtained his first independent position at SUNY/Albany, where his frustrations with the macromolecular crystallization experiment led him one day to the campus pub. There, he realized that the similarity between 6-arm DNA branched junctions and the periodic array of flying fish in Escher's 'Depth' might lead to the rational approach to crystallization described here. He has been trying to implement it ever since, for the last ten years at NYU. Further information is available at http://seemanlab4.chem.nyu.edu.

Copies of the Nature article are available upon request. To set up an interview with Professor Seeman, contact Josh Plaut at 212-998-6797. Reporters with questions for Nature should contact Lauren Funkhouser at 202-737-2355.


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Contact: josh plaut
josh.plaut@nyu.edu
(212) 998-6797
New York University
5-Aug-1998


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