NYU scientists discover gene for a dementing brain disease

NEW YORK, June 23, 1999 -- A single alteration in the DNA alphabet occurring in a newly discovered human gene causes an unusual form of hereditary dementia characterized by amyloid deposits in the brain, one of the hallmarks of Alzheimer's disease, according to a new study by New York University School of Medicine scientists. The discovery solves a longstanding medical mystery involving descendants of a British woman who died in 1883 and may help lead to a better understanding of Alzheimer's and other dementias.

The NYU School of Medicine researchers found the genetic alteration, or mutation, in a gene they dubbed "BRI." The unusual mutation, which occurs at a "stop codon," produces an abnormal protein fragment that forms plaques in the brain of affected family members, according to the new study in June 24 issue of Nature. The researchers developed a blood test to detect the mutation.

"Our hope is that this genetic mutation, which causes a disease as devastating as Alzheimer's, will lead to a better understanding of how neurons are actually lost in the brain," says Jorge Ghiso, Ph.D., Associate Professor of Pathology at NYU School of Medicine, an author of the new study. "This is an important finding because it will give us another window onto the brain diseases associated with amyloid."

According to Creighton H. Phelps, Ph.D., Director of the Alzheimer's Disease Centers Program at the National Institute on Aging, "This exciting discovery provides new opportunities to uncover the cascade of events leading to the loss of synapses and neurons triggering the development of dementia. If we can interfere with this cascade, common to many of the dementias, including Alzheimer's, we may be able to stall the disease process in its tracks."

Amyloid is a general term used to describe proteins that form so-called beta-sheets, which fold in a particular way to form deposits in the brain. A number of brain disorders associated with dementia are linked

Contact: Deborah Miller
New York University Medical Center and School of Medicine

Page: 1 2 3 4

Related biology news :

1. DNA lends scientists a hand, revealing new chemical reactions
2. Conference at UH opens doors for new scientists, engineers
3. Wisconsin scientists develop quick botox test
4. UCI scientists successfully target key HIV protein; breakthrough may lead to new drug therapies
5. Alaska scientists find Arctic tundra yields surprising carbon loss
6. UAF scientists discover new marine habitat in Alaska
7. Information system to help scientists analyze mechanisms of social behavior
8. Zoonotic diseases - European scientists unite to fight diseases
9. Israeli scientists reveal the plan of a key cellular machine
10. Study by Israeli scientists provides insight on DNA code
11. Computer scientists at UH developing nurturing computers

Post Your Comments:

(Date:3/27/2021)... ... March 25, 2021 , ... Phlexglobal announced ... Planet Group, has selected Phlexglobal and its innovative regulatory SaaS software, PhlexSubmission, as ... a comprehensive review of five regulatory software companies, with the review team including ...
(Date:3/27/2021)... ... 25, 2021 , ... The 2021 Virtual Conference on Clinical Trial Supply-Europe ... More and more, clinical trial supply conferences are featuring speakers and forums that ... Asymmetrex’s founder and CEO, James L. Sherley, M.D., Ph.D., presented a talk ...
(Date:3/23/2021)... ... March 23, 2021 , ... G-CON Manufacturing (G-CON), the ... by Matica Biotechnology (Matica Bio), a contract development and manufacturing organization (CDMO) specializing ... the cleanroom build out for its new GMP production facility in College Station, ...
Breaking Biology News(10 mins):
(Date:3/27/2021)... ... March 24, 2021 , ... ... Life Sciences and Healthcare firms of all sizes, adds depth to its team ... specialist. Pardillo, who earned his doctorate in computational chemistry from Florida International University ...
(Date:3/27/2021)... ... March 24, 2021 , ... ABI Wellness, ... and reporting approach designed under CEO Mark Watson, today announced a webinar dedicated ... featuring guest speakers Dr. Cameron Clark, Neuropsychologist and Founder of Sharp Thinking, and ...
(Date:3/27/2021)... ... ... The Xtalks editorial team is pleased to announce the launch of the ... joined by editorial team members Ayesha Rashid, Sydney Perelmutter and Mira Nabulsi to discuss ... including insights from industry experts. , The Xtalks Life Science podcast will feature ...
(Date:3/23/2021)... Conn. (PRWEB) , ... March 23, 2021 , ... ... develops solutions for characterizing microbiome populations down to the strain level, recently unveiled ... applications. , Not all microbes are created equal: some are easy to ...
Breaking Biology Technology:
Cached News: