Nanotech decoys for viruses

Using nanotechnology to stop HIV viruses from entering cells is the ultimate aim of a new project at the University of California, Davis. The researchers hope to create tiny particles that can interfere with the proteins that viruses such as HIV use to attach to cells.

"The idea is to make decoys for the virus," said Jacquelyn Gervay Hague, professor of chemistry at UC Davis and principal investigator on the grant.

HIV attaches itself to a host cell through a protein called gp120 on the virus surface. Gp120 sticks to the CD4 protein on human white blood cells and also to a fatty molecule called galactosyl ceramide, or GalCer. GalCer is found in the membranes of many different types of cell, including cells lining the gut and vagina. Researchers think that binding of gp120 to GalCer may be important in sexual transmission of HIV.

GalCer can form patterns in the cell membrane that allow many gp120 proteins to bind in a specific manner, Gervay Hague said. Materials scientist Marjorie Longo and her lab are studying how GalCer forms these patterns in artificial membranes and how they affect binding to viruses.

If the researchers find a pattern that maximizes binding, they will use tools developed by chemist Gang-yu Liu to recreate those patterns on lipid-coated "quantum dots," tiny particles a few tens of atoms in size. The quantum dots are made by Susan Kauzlarich, a professor of chemistry who studies these very small particles. The particles will be tested for antiviral activity by Satya Dandekar, professor and chair of microbiology and immunology at the UC Davis School of Medicine.

The researchers' ultimate goal is to create a quantum dot that can stick to the virus and prevent it from entering human cells.

The group has already made gold nanoparticles coated with a non-patterned membrane. These particles are not toxic to cells and were able to bind gp120, Gervay Hague said.

The work is funded by a $1.2 mill

Contact: Andy Fell
University of California - Davis

Page: 1 2

Related biology news :

1. National Academies Advisory: Sept. 18-19 Nanotechnology Conference
2. Nanotechnology pioneer slays grey goo myths
3. Nanotechnology highlights from the ACS national meeting in Anaheim, Calif., March 28-April 1
4. Nanotech instruments allow first direct observations of RNA proofreading
5. Nanotechnology: sink or swim?
6. Nanotech strategy could create new organs
7. Cannabis may help combat cancer-causing herpes viruses
8. Scientists find nanowires capable of detecting individual viruses
9. $7.5 Million grant to Yale researchers for role of viruses in cancer
10. Defensive action by influenza viruses demonstrated by Hebrew university researcher
11. Bright idea could doom cancer and viruses, say Purdue scientists

Post Your Comments:

(Date:8/5/2020)... ... , ... Regenative Labs has received approval from the Centers for Medicare & ... first Wharton’s jelly allografts to be assigned a Q code and be approved for ... Wharton’s jelly allograft product to be recognized as a 361 HCT/P by CMS regulated ...
(Date:7/18/2020)... ... July 16, 2020 , ... A study has been published ... Neoasis™ active noise control device to attenuate typical noises in a simulated neonatal ... the alarm sounds from patient monitors, ventilators and other bedside devices that would ...
(Date:7/2/2020)... ... July 01, 2020 , ... AltruBio Inc. http://www.altrubio.com ... a biologic for the treatment of steroid-refractory acute graft-versus-host disease (SR-aGVHD), at European ... J Martin of the Fred Hutchinson Cancer Research Center, this single-arm, open-label Phase ...
Breaking Biology News(10 mins):
(Date:8/12/2020)... FARMS, Mich. (PRWEB) , ... August 12, 2020 ... ... Consulting Group, Inc. (EMMA International), a global leader in FDA compliance consulting ... of the nation’s fastest-growing private companies. The list represents a unique look at ...
(Date:8/3/2020)... (PRWEB) , ... August 03, 2020 , ... ... collection, today announced Jim Corrigan, President and CEO has been named one of ... broad cross-section of industry sectors, PharmaVoice 100 honorees are selected based on how ...
(Date:7/31/2020)... ... July 29, 2020 , ... R3 Stem Cell International is ... $3950. With 50 million stem cells total, patients may choose which extremities they would ... for arthritic joints (BMC Musculoskelet Disord. 2016). At R3 International, umbilical cord tissue is ...
(Date:7/31/2020)... ... July 29, 2020 , ... ... transmitter systems that can be configured to drive Klystrons, TWTs, IOTs, and magnetrons. ... drive one or two switches in a push-pull configuration; yielding fast fall time ...
Breaking Biology Technology:
Cached News: