Narcolepsy gene identified

August 5, 1999 — Researchers who had bred a group of mice in hopes of learning more about a brain hormone that stimulates appetite got a bit of a surprise when they saw that the rodents would suddenly collapse and fall fast asleep with no provocation. As a result, Howard Hughes Medical Institute investigator Masashi Yanagisawa and colleagues at the University of Texas Southwestern Medical Center in Dallas have an exciting new lead into the genesis of sleep and the origins of narcolepsy, a severe sleep disorder in humans.

In 1998, Yanagisawa discovered the orexins, small brain proteins and their receptors that regulate feeding behavior in mice. To probe the role that orexins play in regulating appetite, Yanagisawa and his colleagues developed a strain of knockout mice whose orexin genes do not function properly. After raising several generations of the mice, the investigators videotaped the animals as they went about their daily business, hoping to see how the genetic alteration changed their behavior.

After scrutinizing hundreds of videotapes of mice scampering, grooming, eating, and sleeping, Richard Chemelli, a pediatric research fellow in Yanagisawa’s laboratory, began to feel discouraged because despite months of observation, the knockout mice did not seem any different from their normal, or wild-type, counterparts.

"Then we thought, wait a minute, mice are nocturnal. So watching them during the day is the equivalent of watching human behavior in the middle of the night. They're asleep," explained Yanagisawa. "So we started videotaping them in complete darkness using an infrared camcorder."

Chemelli studied nocturnal surveillance tapes of about 50 knockout mice and began to notice a bizarre and unexpected pattern of behavior. "The mice would be running around, burrowing, grooming themselves. Then all of a sudden, like a switch flipping, they w

Contact: Jim Keeley
Howard Hughes Medical Institute

Page: 1 2 3

Related biology news :

1. Rare childhood genetic syndrome identified
2. Newly identified master gene key in babys first breath
3. Key stimulator of colorectal cancer identified
4. New anti-inflammatory strategy for cancer therapy identified by UCSD researchers
5. A probable cause for high blood pressure identified - shows links with diabetes
6. Millennia still mean early days for newly identified sex chromosome
7. Gene associatied with lupus identified
8. Gene linked to cleft lip and palate identified
9. Last of known genes identified in complex obesity syndrome
10. Leukemia stem cells identified by Stanford researchers
11. New prostate cancer gene identified

Post Your Comments:

(Date:9/3/2020)... ... September 03, 2020 , ... Brilliant , the leading smart ... its products are now available for purchase in the U.S., Canada, and Puerto Rico ... and low-voltage products. In addition to being available for purchase through ADI’s Digital ...
(Date:9/3/2020)... ... September 03, 2020 , ... Litmus ... an extensive third-party assessment of the company’s security practices has been completed. The ... security regulations. The comprehensive evaluation reviewed Litmus’ processes and systems, assessing them to ...
(Date:8/26/2020)... ... August 24, 2020 , ... ... treatment of chronic inflammatory and fibrotic diseases, today announced that Dr. Stacie Canan ... Drug Discovery. , Dr. Canan previously served as Executive Director of Global Health ...
Breaking Biology News(10 mins):
(Date:9/3/2020)... ... September 03, 2020 , ... The ... speakers to present updates on their latest research and technology in the areas ... impact in clinical diagnostics and therapeutic development, as well as the evolving view ...
(Date:9/1/2020)... ... September 01, 2020 , ... ... and diagnostics companies, has announced the placement of Julianne Averill , CPA, ... for leading all financial operations and implementing key business strategies to accelerate Alveo’s ...
(Date:8/31/2020)... WILMINGTON, Del. (PRWEB) , ... August 29, 2020 ... ... of a new Animal Nutrition manufacturing capability in Wuxi, China. The new plant ... DuPont’s global quality standards and advanced technology. , “This facility will improve ...
(Date:8/15/2020)... ... August 13, 2020 , ... True Terpenes , the ... its Scientific Advisory Board (SAB) to research the medical potential of terpenes and the ... when combined with terpenes. The board is focused on expanding the recently launched line ...
Breaking Biology Technology:
Cached News: