HOME >> BIOLOGY >> NEWS
Nasal antibiotic ointment reduces infection risk after surgery

In what may be the largest clinical trial to evaluate the effectiveness of antimicrobial agents in preventing surgical wound and hospital-based infections caused by Staphylococcus aureus, scientists at the University of Iowa and Johns Hopkins found that an antibiotic ointment, called mupirocin (moo-PIE-roe-sin), smeared inside the nose cut infection rates in half or better.

"Our results carry tremendous implications for reducing S. aureus surgical wound and other hospital-based infections, and for preventing illness and saving lives," says Trish Perl, M.D., associate professor of medicine, director of Hospital Epidemiology and Infection Control at Hopkins and an author of the study published in the June 13 issue of the New England Journal of Medicine.

Staphylococcus aureus is a widely distributed germ that normally resides in the nostrils of an estimated 25 to 30 percent of all hospitalized patients without causing harm. But it can contaminate surgical sites, causing severe and often deadly infections, especially in people with weakened immune systems, and contributing millions of dollars yearly to the costs of health care.

In the study, called MARS (for Mupirocin and the Risk of Staphyloccus aureus Infections), the researchers determined the rate of S. aureus surgical wound infections and other hospital-based infections in 4,030 adult patients who underwent various elective surgical procedures at the University of Iowa Hospitals and Clinics and the Veteran's Affairs Medical Center in Iowa City. Mupirocin antibiotic ointment, or a placebo, was applied to the inside of the nostrils twice daily for up to five days before surgery. Patients were followed for 30 days after surgery to determine if they acquired S. aureus infections.

While mupirocin ointment, made by GlaxoSmithKline, is highly effective at reducing the rate of S. aureus infections in patients undergoing surgery, as with any antibiotic, there is the risk of widespread r
'"/>

Contact: Trent Stockton
tstockt1@jhmi.edu
410-955-8665
Johns Hopkins Medical Institutions
12-Jun-2002


Page: 1 2

Related biology news :

1. Nasal contribution to breathing with exercise: The effect of race and gender
2. Could A Nasal Vaccine Finally Get Rid Of The Black Death?
3. Study Shows Athletes Get No Kick From Nasal Strips
4. Anthrax enzyme images reveal secrets of antibiotic resistance, suggest new drug design
5. Smart antibiotics may result from UCLA research
6. K-State researcher working to improve alternatives to equine antibiotics
7. Bacterial protein recycling factor possible key to new class of antibiotics
8. Bacteria spill their guts to aid researchers in quest for new antibiotics
9. Molecule that blocks key bacterial enzyme may lead to new antibiotics
10. Does antibiotic use contribute to allergies?
11. Tigecycline - Candidate antibiotic produces 74 percent cure rate in cSSSI patients

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Nasal antibiotic ointment reduces infection risk after surgery

(Date:8/28/2014)... healthier for your neighbors than traditional cigarettes, but ... a new study from USC. , Scientists studying ... decrease in exposure to harmful particles, with close-to-zero ... to some harmful metals in second-hand e-cigarette smoke ... tobacco smoke contains high levels of polycyclic aromatic ...
(Date:8/28/2014)... Access to Research Careers) Program has announced the ... America,s 27th Annual Mouse Molecular Genetics Conference from ... Grove, California. These awards are meant to ... scientists from underrepresented groups into the mainstream of ... participation of young scientists at the Genetics Society ...
(Date:8/28/2014)... delivering compounds that could positively impact the ... be possible, thanks to researchers in Penn ... vaginal suppository made from the seaweed-derived food ... drug Tenofovir provides a woman-initiated, drug-delivery vehicle ... sexually transmitted infections during unprotected heterosexual intercourse, ...
Breaking Biology News(10 mins):Second-hand e-cig smoke compared to regular cigarette smoke 2Sensory-tested drug-delivery vehicle could limit spread of HIV, AIDS 2Sensory-tested drug-delivery vehicle could limit spread of HIV, AIDS 3
(Date:8/28/2014)... 28, 2014 PrimeSource Building Products, ... selected SoundConnect to support their communication ... audio and web conferencing platform GlobalMeet powered by ... employees’ needs. SoundConnect delivers award winning “results ... Building Products will be utilizing GlobalMeet powered ...
(Date:8/27/2014)... , Aug. 27, 2014 Rhythm, a biopharmaceutical ... genetic deficiencies that result in metabolic disorders, announced today ... S-1 with the U.S. Securities and Exchange Commission (SEC) ... of its common stock. The number of shares to ... have not yet been determined. Citigroup and ...
(Date:8/27/2014)... (PRWEB) August 27, 2014 The Global ... in-depth study on the current state of the Trifluoroacetic ... provides a basic overview of the industry, including definitions, ... Chinese domestic market analysis are provided with a focus ... market. A comparison between the international and Chinese situation ...
(Date:8/27/2014)... 2014 “We are honored to be ... Ven Thangaraj, CEO of Radiant Sage. “We are offering ... the imaging corelab market to a different level. ... organizations to efficiently and effectively manage the massive amounts ... be analyzed and read by trained physicians. Being recognized ...
Breaking Biology Technology:PrimeSource Chooses SoundConnect as Collaboration Provider 2Rhythm Files Registration Statement for Proposed Initial Public Offering 2Trifluoroacetic Acid Industry (Asia, Europe, North America, ROW) Analysis Report Now Available at ReportsnReports.com 2Radiant Sage Named to CIOReview List of 100 Most Promising Technology Companies 2
Cached News: