HOME >> BIOLOGY >> NEWS
Natural resistance of pigment cells to sunlight may make deadly skin cancer tough to treat

screen cells, the melanocytes, are continuously bombarded by ultraviolet solar radiation as they generate pigment which protects underlying skin cells. Ordinarily, the melanocytes would become damaged from the radiation and apoptosis may be initiated, unless there were some countervailing force. And there is: During human evolution, melanocytes appear to have acquired at least one such mechanism that neutralizes apoptosis and enables the cells to survive. The main players in this apoptosis-blocking game are MITF and another gene with which it interacts, BCL2.

The MITF gene, dubbed by scientists as the master melanocyte regulator, is found in melanocytes and is critical for their proper development and their long-term survival. In addition MITF is thought to play a key role in production of pigment by these cells. BCL2 is a cell-death suppressor, many of whose actions were discovered by Dana-Farber researcher Stanley J. Korsmeyer, MD.

When either the MITF or BCL2 gene is mutated or missing, the whiskers and fur of mice turn from black to gray or white because melanocytes have died. A mutant MITF gene is involved in a human genetic disorder that causes, among other abnormalities, locks of white hair from birth.

The investigators used microarrays, or DNA chips, to determine what genes are turned on when the MITF gene is active, i.e., what genes are targets of MITF within normal melanocytes. The microarray experiments showed that the protein produced by MITF links up with the BCL2 gene both in normal melanocytes and in melanoma cells, increasing the amount of BCL2 protein being made, and activating cell survival.

McGill and others in the Fisher lab also inhibited the activity of MITF in melanocytes and melanoma cells by infecting them with genetically engineered viruses. When the viruses blocked the action of MITF, the cells died. By the same token, the researchers could artificially rev up the activity of BCL2 in MITF-inhibited melano
'"/>

Contact: Bill Schalaler
william_schaller@dfci.harvard.edu
617-632-5357
Dana-Farber Cancer Institute
13-Jun-2002


Page: 1 2 3

Related biology news :

1. Natural mineral locks up carbon dioxide
2. Naturalists of the Isthmus of Panama
3. Natural selection at work in genetic variation to taste
4. Natural, man-made mix promises biggest landscape plant growth
5. Natural enemies help scientists untangle tropical forest food webs
6. Natural killer cellers are made, not born
7. Natural selection in a nutshell
8. Natural fat compound may be basis for new class of drugs targeting obesity
9. Natural hormone could reverse heart damage
10. New biography details adventures of Fritz Muller, A Naturalist in Brazil
11. Natural selections fingerprint identified on fruit fly evolution

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/15/2016)... York , March 15, 2016 ... market report published by Transparency Market Research "Digital Door Lock ... and Forecast 2015 - 2023," the global digital door lock ... 731.9 Mn in 2014 and is forecast to grow at ... Growth of micro, small and medium enterprises (MSMEs) across the ...
(Date:3/14/2016)... Allemagne, March 14, 2016 ... - --> - Renvoi : image disponible ... --> --> DERMALOG, ... fournit de nouveaux lecteurs d,empreintes digitales pour l,enregistrement ... DERMALOG sera utilisé pour produire des cartes d,identité ...
(Date:3/10/2016)... India , March 10, 2016 ... a new market research report "Identity and Access Management ... & Audit, Compliance, and Governance), by Organization Size, by ... to 2020", published by MarketsandMarkets, The market is estimated ... USD 12.78 Billion by 2020, at a Compound Annual ...
Breaking Biology News(10 mins):
(Date:4/29/2016)... Louisville, KY and San Diego, CA (PRWEB) , ... April 29, ... ... the National Stem Cell Foundation (NSCF) to support the development of a patient-specific stem ... by Dr. Andrés Bratt-Leal in the lab of Dr. Jeanne Loring at The Scripps ...
(Date:4/28/2016)... -- The report "Cryocooler Market by Type ... Support, Product Repairs & Refurbishment, Preventive Maintenance, and Customer ... published by MarketsandMarkets, the global market is expected to ... CAGR of 7.29% between 2016 and 2022. ... spread through 159 Pages and in-depth TOC on  "Cryocooler ...
(Date:4/28/2016)... ... April 28, 2016 , ... Next week ... talk on its first-in-class technologies for tissue stem cell counting and expansion to ... Biology to Reprogramming & CRISPR-based Genome Engineering in Burlington, Massachusetts. , The attention ...
(Date:4/27/2016)... ... April 27, 2016 , ... Cambridge Semantics, the ... technology, today announced that it has been named to The Silicon Review’s “20 Fastest ... and other markets, Cambridge Semantics serves the needs of end users facing some of ...
Breaking Biology Technology:
Cached News: