HOME >> BIOLOGY >> NEWS
Natural resistance of pigment cells to sunlight may make deadly skin cancer tough to treat

screen cells, the melanocytes, are continuously bombarded by ultraviolet solar radiation as they generate pigment which protects underlying skin cells. Ordinarily, the melanocytes would become damaged from the radiation and apoptosis may be initiated, unless there were some countervailing force. And there is: During human evolution, melanocytes appear to have acquired at least one such mechanism that neutralizes apoptosis and enables the cells to survive. The main players in this apoptosis-blocking game are MITF and another gene with which it interacts, BCL2.

The MITF gene, dubbed by scientists as the master melanocyte regulator, is found in melanocytes and is critical for their proper development and their long-term survival. In addition MITF is thought to play a key role in production of pigment by these cells. BCL2 is a cell-death suppressor, many of whose actions were discovered by Dana-Farber researcher Stanley J. Korsmeyer, MD.

When either the MITF or BCL2 gene is mutated or missing, the whiskers and fur of mice turn from black to gray or white because melanocytes have died. A mutant MITF gene is involved in a human genetic disorder that causes, among other abnormalities, locks of white hair from birth.

The investigators used microarrays, or DNA chips, to determine what genes are turned on when the MITF gene is active, i.e., what genes are targets of MITF within normal melanocytes. The microarray experiments showed that the protein produced by MITF links up with the BCL2 gene both in normal melanocytes and in melanoma cells, increasing the amount of BCL2 protein being made, and activating cell survival.

McGill and others in the Fisher lab also inhibited the activity of MITF in melanocytes and melanoma cells by infecting them with genetically engineered viruses. When the viruses blocked the action of MITF, the cells died. By the same token, the researchers could artificially rev up the activity of BCL2 in MITF-inhibited melano
'"/>

Contact: Bill Schalaler
william_schaller@dfci.harvard.edu
617-632-5357
Dana-Farber Cancer Institute
13-Jun-2002


Page: 1 2 3

Related biology news :

1. Natural mineral locks up carbon dioxide
2. Naturalists of the Isthmus of Panama
3. Natural selection at work in genetic variation to taste
4. Natural, man-made mix promises biggest landscape plant growth
5. Natural enemies help scientists untangle tropical forest food webs
6. Natural killer cellers are made, not born
7. Natural selection in a nutshell
8. Natural fat compound may be basis for new class of drugs targeting obesity
9. Natural hormone could reverse heart damage
10. New biography details adventures of Fritz Muller, A Naturalist in Brazil
11. Natural selections fingerprint identified on fruit fly evolution

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/6/2017)... , April 6, 2017 Forecasts ... ANPR, Document Readers, by End-Use (Transportation & Logistics, Government ... Oil, Gas & Fossil Generation Facility, Nuclear Power), Industrial, ... Other) Are you looking for a definitive ... ...
(Date:4/5/2017)... , April 4, 2017 KEY FINDINGS ... anticipated to expand at a CAGR of 25.76% during ... diseases is the primary factor for the growth of ... report: https://www.reportbuyer.com/product/4807905/ MARKET INSIGHTS The global ... product, technology, application, and geography. The stem cell market ...
(Date:3/30/2017)... March 30, 2017  On April 6-7, 2017, Sequencing.com ... Genome hackathon at Microsoft,s headquarters in ... will focus on developing health and wellness apps that ... Hack the Genome is the first hackathon for ... world,s largest companies in the genomics, tech and health ...
Breaking Biology News(10 mins):
(Date:7/24/2017)... Lawrence, MA (PRWEB) , ... July 24, 2017 , ... ... (TET-SL) has been accepted by the National Conference on Interstate Milk Shipments (NCIMS) Laboratory ... its Pilot Program, set to launch July 1, 2017. , The NCIMS voted at ...
(Date:7/24/2017)... ... July 24, 2017 , ... ... today announced that the stock market news outlet had initiated coverage on ... testing that screens and identifies exposure, progression and risk analysis from specific ...
(Date:7/20/2017)... , ... July 20, 2017 , ... Dr. Asher Kimchi, ... winning recipients of the 2017 IAC Awards at the 22nd World Congress on Heart ... also named four faculty to receive the Distinguished Fellowship Awards. , Dr. Asher Kimchi, ...
(Date:7/20/2017)... ... July 20, 2017 , ... Corista, a leader in ... intelligence Tuesday, July 25, during the Association of Pathology Chairs’ Jubilee Meeting in ... , Baras, Associate Director of Pathology Informatics, will present “The Digital Pathology Experience ...
Breaking Biology Technology:
Cached News: