HOME >> BIOLOGY >> NEWS
Naturally occurring protein could slow Alzheimer's disease

April 3, 2001 - A laboratory "fishing expedition" landed a surprising catch for researchers: a cholesterol-lowering protein produced by the body that might be able to slow the progression of Alzheimer's disease.

The findings are reported in the current (March 27) issue of Biochemistry, a peer-reviewed journal of the American Chemical Society, the world's largest scientific society.

Using a protein implicated in Alzheimer's disease - amyloid precursor protein - for bait, University of Pittsburgh researchers trolled a "lake" of chemicals specifically designed to simulate the human body to see what might grab their unusual lure. A small part of amyloid precursor protein forms a chemical called beta amyloid, which becomes the most important part of the Alzheimer's disease plaques that strangle normal brain cells.

The bait eventually produced a bite, another protein called Apolipoprotein A-1.

Everyone has some quantity of Apolipoprotein A-1, or Apo-A, in their body, says Dr. Radosveta Koldamova, M.D., Ph.D., a member of the research team. It is produced in the small intestine and the liver and is known to help prevent coronary heart disease. At normal levels, the protein clears cholesterol throughout the body, including in the brain. The scientists speculate that boosting Apo-A levels may also help clear beta amyloid.

The researchers think that increasing the concentrations of Apo-A in blood might delay the dementia associated with Alzheimer's disease. Further testing is needed to confirm their hypothesis, they add. Another such protein, Apolipoprotein E, has been similarly linked with Alzheimer's and is being studied by other researchers.

"You begin to think about whether or not changing Apo-A levels in the blood could benefit Alzheimer's patients," Koldamova said.

One way to raise the levels of the protein naturally is through a good diet, according to Professor John S. Lazo, Ph.D., who led the research study. Previous findings indicate
'"/>

Contact: Beverly Hassell
b_hassell@acs.org
202-872-4065
American Chemical Society
1-Apr-2001


Page: 1 2

Related biology news :

1. Blocking Autoimmunity Naturally
2. Naturally Produced Enzyme May Be Useful In Inflammatory Arthritis
3. TSRI Scientists Discover Naturally-Occurring Mechanism Involved In Regulation Of Angiogenesis; New Anti-Cancer Therapeutic Agents Are Suggested
4. Researchers discover new family of naturally occurring antibiotics
5. Using a mouse model, reserchers now understand changes occurring in the brain before the onset of Huntingtons disease
6. A little help from below: naturally occurring microbes ready to lend a hand trapping radioactivity underground
7. New molecular link key to cellular proteins involved in cancer progression, other diseases
8. Researchers identify protein promoting vascular tumor growth
9. UCI scientists successfully target key HIV protein; breakthrough may lead to new drug therapies
10. Experimental drug shown to block mutant protein causing blood disease
11. Loss of the neuronal adhesion protein d-catenin leads to severe cognitive dysfunction

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/23/2017)...  The general public,s help is being enlisted in what,s thought to ... and on the human body –and are believed to affect health.  ... The Microbiome Immunity Project is the largest ... the gut. The project's goal is to help advance scientific knowledge of ... ...
(Date:6/14/2017)...  IBM (NYSE: IBM ) is introducing several innovative ... to developing collaboration between startups and global businesses, taking place ... the event, nine startups will showcase the solutions they have ... France is one ... a 30 percent increase in the number of startups created ...
(Date:4/24/2017)... , April 24, 2017 ... and partner with  Identity Strategy Partners, LLP (IdSP) ... "With or without President Trump,s March 6, 2017 ... Terrorist Entry , refugee vetting can be instilled with ... resettlement. (Right now, all refugee applications are suspended ...
Breaking Biology News(10 mins):
(Date:10/9/2017)... (PRWEB) , ... October 09, 2017 , ... The award-winning ... to broadcast first quarter 2018. American Farmer airs Tuesdays at 8:30aET on RFD-TV. ... is faced with the challenge of how to continue to feed a growing nation. ...
(Date:10/9/2017)... Arizona (PRWEB) , ... October 09, 2017 , ... ... Kindred, a four-tiered line of medical marijuana products targeting the needs of consumers ... and packaging of Kindred takes place in Phoenix, Arizona. , As operators of ...
(Date:10/7/2017)... ... October 06, 2017 , ... ... for microscopy and surface analysis, Nanoscience Instruments is now expanding into Analytical ... broad range of contract analysis services for advanced applications. Services will leverage ...
(Date:10/7/2017)... Mass. , Oct. 6, 2017  The ... work of three scientists, Jacques Dubochet, Joachim ... breakthrough developments in cryo-electron microscopy (cryo-EM) ... technology within the structural biology community. The winners ... Scientists can now routinely produce highly resolved, three-dimensional ...
Breaking Biology Technology:
Cached News: