HOME >> BIOLOGY >> NEWS
Nature's chemical weapons save lives

COLLEGE STATION, -Chemical warfare isn't just for humans. Some marine organisms have a knack for it, too, and chemists at Texas A&M University think the sea-life version might have medical applications.

"Many marine organisms have developed chemical means to defend themselves. These chemical warfare agents continue to be useful lead compounds for cellular studies and drug development," said Daniel Romo, a synthetic organic chemist and associate professor in the Department of Chemistry at Texas A&M.

One of Romo's current research interests is structural, synthetic, and biomechanistic investigations of marine natural products displaying potent physiological effects.

One such compound, pateamine A, isolated from a marine sponge found off the shores of New Zealand, has been studied by Romo's group for seven years. Its novel structure and immunosuppressive activity drew the group's interest.

"Immunosuppressive compounds are used clinically for patients undergoing organ transplantation," Romo said. "Such compounds are given to moderate the activity of the immune system so that the body does not reject the organ."

Romo's group completed a total synthesis of Pateamine A in 1998, putting together this complex molecule bond by bond from simple and commercially available starting materials.

Since that time, Romo's group has been synthesizing derivatives of this natural product based on the published synthetic route. One set of derivatives will enable these chemists, in collaboration with biochemists, to find a potentially new cellular protein involved in the normal human immune response.

The hypothesis is that binding of pateamine A to this protein is the basis of its immunosuppressive effects. They also hope to find compounds that have increased chemical stability and potentially increased immunosuppressive activity.

This study has the potential to lead to the development of new immunosuppressive drugs. In fa
'"/>

Contact: Keith Randall
kr@univrel.tamu.edu
979-845-4644
Texas A&M University
31-Aug-2001


Page: 1 2 3

Related biology news :

1. Natures ambush: pregnancy more likely from single unprotected intercourse than believed
2. Researchers discover structure of Natures circuit breaker
3. Natures own antidote to cocaine
4. Natures own medicine for vision loss: Inhibitor of angiogenesis found by biologists at The Scripps Research Institute
5. Natures path leads scientists to new antibiotic strategy
6. Worlds Leading Echinacea Researchers To Examine Latest Scientific Findings On "Natures Gentle Antibiotic"
7. Natures Sugar High
8. Photosynthetic Harvest Inc. Harnesses The Power Of Natures Chemical Factories By "Milking" Green Plants For Valuable Natural Products
9. DNA lends scientists a hand, revealing new chemical reactions
10. Grant advances biochemical engineering laboratory
11. Bullish chemical could repel yellow fever mosquitoes

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:11/23/2018)... , ... November 23, 2018 , ... ... Emeran Mayer, MD, Executive Director of the G. Oppenheimer Center for Neurobiology of ... scientists and doctors from around the world, Dr. Mayer will bring to uBiome ...
(Date:11/20/2018)... ... ... Thanks to its long-standing expertise in ID reader development and industrialization, Elyctis is ... now proposes a full range of readers able to satisfy all needs including usage ... by professionals either in a fixed location or on the move as well as ...
(Date:11/16/2018)... PHILLADELPHIA (PRWEB) , ... November 16, 2018 , ... ... Jr., P.G., was awarded the International Bottled Water Association’s (IBWA’s) IBWA/Shayron Barnes-Selby ... week. , IBWA’s Advocacy Award, named “The Selby” after longtime IBWA contributor Shayron ...
Breaking Biology News(10 mins):
(Date:11/5/2018)... ... 05, 2018 , ... USARAD Holdings Inc., the leading US ... healthcare VC firms announces at Distributed Health 2018 conference November 5-6 (Nashville, TN) ... and obtaining its first radiology interpretations, one of the first known true use ...
(Date:11/3/2018)... ... 01, 2018 , ... Come to Princeton Nov. 14 and ... Division of Clinical Compliance Evaluation, CDER, FDA will be presenting on using data ... should clinical research industry stakeholders keep in mind when implementing and managing risk-based ...
(Date:10/31/2018)... ... 30, 2018 , ... Myoscience, Inc. announced today that it ... Memphis, Tennessee. This study enrolled 125 patients and compares the effect of ... after total knee replacement surgery (TKA). , The Myoscience iovera° system is currently ...
(Date:10/31/2018)... ... 2018 , ... Today, the National Corn Growers Association (NCGA) announced the launch ... to find new and innovative uses of field corn. NineSigma is serving as the ... of corn and are on pace to produce the second largest crop ever. One ...
Breaking Biology Technology:
Cached News: