HOME >> BIOLOGY >> NEWS
Nature's chemical weapons save lives

COLLEGE STATION, -Chemical warfare isn't just for humans. Some marine organisms have a knack for it, too, and chemists at Texas A&M University think the sea-life version might have medical applications.

"Many marine organisms have developed chemical means to defend themselves. These chemical warfare agents continue to be useful lead compounds for cellular studies and drug development," said Daniel Romo, a synthetic organic chemist and associate professor in the Department of Chemistry at Texas A&M.

One of Romo's current research interests is structural, synthetic, and biomechanistic investigations of marine natural products displaying potent physiological effects.

One such compound, pateamine A, isolated from a marine sponge found off the shores of New Zealand, has been studied by Romo's group for seven years. Its novel structure and immunosuppressive activity drew the group's interest.

"Immunosuppressive compounds are used clinically for patients undergoing organ transplantation," Romo said. "Such compounds are given to moderate the activity of the immune system so that the body does not reject the organ."

Romo's group completed a total synthesis of Pateamine A in 1998, putting together this complex molecule bond by bond from simple and commercially available starting materials.

Since that time, Romo's group has been synthesizing derivatives of this natural product based on the published synthetic route. One set of derivatives will enable these chemists, in collaboration with biochemists, to find a potentially new cellular protein involved in the normal human immune response.

The hypothesis is that binding of pateamine A to this protein is the basis of its immunosuppressive effects. They also hope to find compounds that have increased chemical stability and potentially increased immunosuppressive activity.

This study has the potential to lead to the development of new immunosuppressive drugs. In fa
'"/>

Contact: Keith Randall
kr@univrel.tamu.edu
979-845-4644
Texas A&M University
31-Aug-2001


Page: 1 2 3

Related biology news :

1. Natures ambush: pregnancy more likely from single unprotected intercourse than believed
2. Researchers discover structure of Natures circuit breaker
3. Natures own antidote to cocaine
4. Natures own medicine for vision loss: Inhibitor of angiogenesis found by biologists at The Scripps Research Institute
5. Natures path leads scientists to new antibiotic strategy
6. Worlds Leading Echinacea Researchers To Examine Latest Scientific Findings On "Natures Gentle Antibiotic"
7. Natures Sugar High
8. Photosynthetic Harvest Inc. Harnesses The Power Of Natures Chemical Factories By "Milking" Green Plants For Valuable Natural Products
9. DNA lends scientists a hand, revealing new chemical reactions
10. Grant advances biochemical engineering laboratory
11. Bullish chemical could repel yellow fever mosquitoes

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/6/2019)... FRANCISCO (PRWEB) , ... February 04, 2019 , ... ... of a new Explorer™ story which provides insights to help individuals understand how ... to decreased cardiovascular wellness. , After individuals eat foods that contain choline ...
(Date:2/2/2019)... ... February 01, 2019 , ... uBiome, ... Testing Laboratories by A2LA, which establishes requirements for medical laboratories to demonstrate competence ... is already CLIA-licensed as well as College of American Pathologists (CAP)-accredited, a designation ...
(Date:1/24/2019)... ... 23, 2019 , ... rHEALTH LLC, an innovative digital health ... the United States Patent and Trademark Office (USPTO) for U.S. Patent Application No. ... This application covers the addition of a length scale to hydrogel microparticles. ...
Breaking Biology News(10 mins):
(Date:1/15/2019)... ... 15, 2019 , ... Personalized treatment plans may extend life expectancy for early-stage ... new study published in the journal Radiology. , Kidney, or renal, tumors are ... surgical procedure in which the tumor and part of the kidney are removed. However, ...
(Date:1/11/2019)... ... 11, 2019 , ... Drawing on over 22 years of software development expertise, ... EST will explore some of the key lessons that have driven customer satisfaction with ... multiple vendors, and find out how to ensure that you continue to be able ...
(Date:1/10/2019)... (PRWEB) , ... January 08, 2019 , ... VGI Medical ... has become a leader in bringing innovation to the market including VerteLoc, CerLoc, SiJoin ... the facet joint by utilizing a unique patented dual geometric design to limit motion ...
(Date:1/7/2019)... ... 07, 2019 , ... Kainos Medicine Inc. today announced that ... code-named "KM-819." KM-819 is an orally active small molecule that is a ... , This Phase 1 randomized, double-blind, placebo-controlled dose-escalation study was to evaluate ...
Breaking Biology Technology:
Cached News: