HOME >> BIOLOGY >> NEWS
Nature's chemical weapons save lives

COLLEGE STATION, -Chemical warfare isn't just for humans. Some marine organisms have a knack for it, too, and chemists at Texas A&M University think the sea-life version might have medical applications.

"Many marine organisms have developed chemical means to defend themselves. These chemical warfare agents continue to be useful lead compounds for cellular studies and drug development," said Daniel Romo, a synthetic organic chemist and associate professor in the Department of Chemistry at Texas A&M.

One of Romo's current research interests is structural, synthetic, and biomechanistic investigations of marine natural products displaying potent physiological effects.

One such compound, pateamine A, isolated from a marine sponge found off the shores of New Zealand, has been studied by Romo's group for seven years. Its novel structure and immunosuppressive activity drew the group's interest.

"Immunosuppressive compounds are used clinically for patients undergoing organ transplantation," Romo said. "Such compounds are given to moderate the activity of the immune system so that the body does not reject the organ."

Romo's group completed a total synthesis of Pateamine A in 1998, putting together this complex molecule bond by bond from simple and commercially available starting materials.

Since that time, Romo's group has been synthesizing derivatives of this natural product based on the published synthetic route. One set of derivatives will enable these chemists, in collaboration with biochemists, to find a potentially new cellular protein involved in the normal human immune response.

The hypothesis is that binding of pateamine A to this protein is the basis of its immunosuppressive effects. They also hope to find compounds that have increased chemical stability and potentially increased immunosuppressive activity.

This study has the potential to lead to the development of new immunosuppressive drugs. In fa
'"/>

Contact: Keith Randall
kr@univrel.tamu.edu
979-845-4644
Texas A&M University
31-Aug-2001


Page: 1 2 3

Related biology news :

1. Natures ambush: pregnancy more likely from single unprotected intercourse than believed
2. Researchers discover structure of Natures circuit breaker
3. Natures own antidote to cocaine
4. Natures own medicine for vision loss: Inhibitor of angiogenesis found by biologists at The Scripps Research Institute
5. Natures path leads scientists to new antibiotic strategy
6. Worlds Leading Echinacea Researchers To Examine Latest Scientific Findings On "Natures Gentle Antibiotic"
7. Natures Sugar High
8. Photosynthetic Harvest Inc. Harnesses The Power Of Natures Chemical Factories By "Milking" Green Plants For Valuable Natural Products
9. DNA lends scientists a hand, revealing new chemical reactions
10. Grant advances biochemical engineering laboratory
11. Bullish chemical could repel yellow fever mosquitoes

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/23/2020)... ... January 23, 2020 , ... GIOSTAR/HEAMGEN ... from stem cells. The red blood cells are made utilizing a bioreactor ... for transfusion therapy and replaces the need for a human blood donor. ...
(Date:1/22/2020)... ... January 21, 2020 , ... Astro Pak’s president ... Business Development Department. The move, which is part of the company’s structural reorganization, ... the company’s Senior Vice President where he oversaw its Cleanroom Division as well ...
(Date:1/10/2020)... ... January 09, 2020 , ... Cutting Edge Spine, a ... 510(K) clearance and commercial launch of the latest addition to its bioactive portfolio ... EVOL®ha-DLIF is made of PEEK-OPTIMA HA Enhanced material supplied by Invibio Biomaterial Solutions. ...
Breaking Biology News(10 mins):
(Date:2/19/2020)... ... 2020 , ... Red Nucleus, a leading provider of strategic ... opening of a new office in Tokyo, Japan. The new office will be ... the new office in response to customer requests for regional coverage. Customers headquartered ...
(Date:2/5/2020)... Conn. (PRWEB) , ... February 04, 2020 , ... ... develops tools for characterizing microbiome populations down to the strain level, has announced ... will sell Shoreline Biome’s microbiome kits and other products to companies and research ...
(Date:1/28/2020)... ... January 28, 2020 , ... ... announced the release of Genedata Expressionist ® 13.5 at the 2020 ... Multi-Attribute Methods (MAM) for characterizing and monitoring the quality of biopharmaceuticals throughout ...
(Date:1/24/2020)... ... January 24, 2020 , ... The ... in biotechnology, diagnostics, therapeutics, laboratory and clinical services during the first two decades ... the world. And as Slone Partners celebrates its 20th anniversary this ...
Breaking Biology Technology:
Cached News: