HOME >> BIOLOGY >> NEWS
Nature's path leads scientists to new antibiotic strategy

MADISON - By mimicking one of nature's own potent antimicrobial defenses, scientists may have found a new way to wage war on pathogenic bacteria.

Writing this week (April 6) in the British scientific journal Nature, a team of scientists from the University of Wisconsin-Madison report the design, synthesis and evaluation of a new type of molecule that exhibits a wide spectrum of antimicrobial activity, including against two species of bacteria that are resistant to common antibiotic drugs.

The work is important because it demonstrates the feasibility of developing a new class of antibiotics that can potentially overcome the growing resistance of disease-causing bacteria to current medicines, according to UW-Madison chemistry Professor Samuel H. Gellman, an author of the new study. Moreover, the work reveals the potential of using nature as a guide to build medically important synthetic molecules that can outperform their naturally-occurring counterparts.

"Nearly all antimicrobial agents now used in clinical settings are naturally-occurring molecules, or are closely related to molecules found in nature," Gellman said. "In contrast, our new antimicrobials are very different from all molecules found in nature. The upshot of this research is that we may be on a radical new path that may lead to the rational, deliberate design of clinically useful molecules like antibiotics."

The design of the new antibacterial agents involved mimicry of naturally-occurring peptides that ward off microbial invasion.

Peptides are composed of alpha-amino acids which also are the building blocks of protein molecules and are essential to all life. In nature, peptides can be selectively toxic to invading microorganisms, forming a first line of antimicrobial defense in everything from plants to people. The natural antibiotic peptides, however, are rapidly degraded in living tissues and can be highly toxic to human cells in addition to infectious
'"/>

Contact: Samuel H. Gellman
gellman@chem.wisc.edu
608-262-3303
University of Wisconsin-Madison
4-Apr-2000


Page: 1 2 3

Related biology news :

1. Natures ambush: pregnancy more likely from single unprotected intercourse than believed
2. Researchers discover structure of Natures circuit breaker
3. Natures own antidote to cocaine
4. Natures own medicine for vision loss: Inhibitor of angiogenesis found by biologists at The Scripps Research Institute
5. Natures chemical weapons save lives
6. Worlds Leading Echinacea Researchers To Examine Latest Scientific Findings On "Natures Gentle Antibiotic"
7. Natures Sugar High
8. Photosynthetic Harvest Inc. Harnesses The Power Of Natures Chemical Factories By "Milking" Green Plants For Valuable Natural Products
9. Loss of the neuronal adhesion protein d-catenin leads to severe cognitive dysfunction
10. Cockroach-like robot leads new research effort
11. Washington University in St. Louis leads group studying aging process

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/6/2020)... ... February 06, 2020 , ... Syntactx, ... device and pharmaceutical trials, announced that Ms. Dorothy Abel has joined the ... oversees the development and execution of regulatory plans designed to help clients ...
(Date:2/1/2020)... ... 01, 2020 , ... Liver cancer, called hepatocellular carcinoma (HCC), occurs each year ... disease. HCC is the 5th most common cancer and the 2nd leading cause of ... to incidence of HCC, while China has half of all patients suffering from liver ...
(Date:1/29/2020)... ... January 29, 2020 , ... ... it will start production of a DNA vaccine against the novel coronavirus (2019-nCoV) ... Pharmaceuticals. A grant of up to $9 million from the Coalition for Epidemic ...
Breaking Biology News(10 mins):
(Date:1/24/2020)... ... January 24, 2020 , ... The impact of new medicines, ... laboratory and clinical services during the first two decades of the 21st century ... Slone Partners celebrates its 20th anniversary this year, its evolution as ...
(Date:1/22/2020)... FRANKLIN, Wis. (PRWEB) , ... January 21, 2020 ... ... announce the hiring of Darrell Taylor as Southern Midwest Region Industrial and Institutional ... to the SporActiv™ product line. , Darrell brings over 30 years ...
(Date:1/10/2020)... ... January 09, 2020 , ... ... services, today announced the acquisition of Cunesoft, a move that expands the company’s ... objectives of life sciences companies. , Based in Munich, Germany, Cunesoft provides intelligent ...
(Date:1/7/2020)... ... January 07, 2020 , ... Absolute Antibody Ltd. ... launch of its VivopureX™ recombinant mouse antibodies for in vivo research in mouse ... or hamsters, which Absolute Antibody has engineered into mouse-anti-mouse recombinant versions to improve ...
Breaking Biology Technology:
Cached News: