HOME >> BIOLOGY >> NEWS
Nature's path leads scientists to new antibiotic strategy

MADISON - By mimicking one of nature's own potent antimicrobial defenses, scientists may have found a new way to wage war on pathogenic bacteria.

Writing this week (April 6) in the British scientific journal Nature, a team of scientists from the University of Wisconsin-Madison report the design, synthesis and evaluation of a new type of molecule that exhibits a wide spectrum of antimicrobial activity, including against two species of bacteria that are resistant to common antibiotic drugs.

The work is important because it demonstrates the feasibility of developing a new class of antibiotics that can potentially overcome the growing resistance of disease-causing bacteria to current medicines, according to UW-Madison chemistry Professor Samuel H. Gellman, an author of the new study. Moreover, the work reveals the potential of using nature as a guide to build medically important synthetic molecules that can outperform their naturally-occurring counterparts.

"Nearly all antimicrobial agents now used in clinical settings are naturally-occurring molecules, or are closely related to molecules found in nature," Gellman said. "In contrast, our new antimicrobials are very different from all molecules found in nature. The upshot of this research is that we may be on a radical new path that may lead to the rational, deliberate design of clinically useful molecules like antibiotics."

The design of the new antibacterial agents involved mimicry of naturally-occurring peptides that ward off microbial invasion.

Peptides are composed of alpha-amino acids which also are the building blocks of protein molecules and are essential to all life. In nature, peptides can be selectively toxic to invading microorganisms, forming a first line of antimicrobial defense in everything from plants to people. The natural antibiotic peptides, however, are rapidly degraded in living tissues and can be highly toxic to human cells in addition to infectious
'"/>

Contact: Samuel H. Gellman
gellman@chem.wisc.edu
608-262-3303
University of Wisconsin-Madison
4-Apr-2000


Page: 1 2 3

Related biology news :

1. Natures ambush: pregnancy more likely from single unprotected intercourse than believed
2. Researchers discover structure of Natures circuit breaker
3. Natures own antidote to cocaine
4. Natures own medicine for vision loss: Inhibitor of angiogenesis found by biologists at The Scripps Research Institute
5. Natures chemical weapons save lives
6. Worlds Leading Echinacea Researchers To Examine Latest Scientific Findings On "Natures Gentle Antibiotic"
7. Natures Sugar High
8. Photosynthetic Harvest Inc. Harnesses The Power Of Natures Chemical Factories By "Milking" Green Plants For Valuable Natural Products
9. Loss of the neuronal adhesion protein d-catenin leads to severe cognitive dysfunction
10. Cockroach-like robot leads new research effort
11. Washington University in St. Louis leads group studying aging process

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Nature path leads scientists new antibiotic strategy

(Date:3/10/2015)... March 10, 2015  Continuing its 167-year history of ... Schlemmer introduces The Eye Scanning Password Authenticator , ... access to secure websites or sensitive data. ... at international borders, the device has a small camera ... of the iris, converting them into an encrypted ID ...
(Date:3/4/2015)... --Research and Markets ( http://www.researchandmarkets.com/research/48tj8z/global_biometrics ) ... Biometrics Market Forecast and Opportunities, 2020" report ... biometric authentication systems is projected to grow at ... The driving forces for this highly competitive ... and constant development in technology. In 2014, government ...
(Date:2/25/2015)... , Feb. 25, 2015  ABC Financial ... billing in the Health and Fitness Industry, today ... as to MYiCLUBonline.  The latest upgrade includes advances ... inclusion of cardless check-in via Identity One fingerprint ... first time through interactive displays at the International ...
Breaking Biology News(10 mins):Hammacher Schlemmer Introduces The Eye Scanning Password Authenticator 2Global Biometrics Market Forecast and Opportunities, 2020 2Global Biometrics Market Forecast and Opportunities, 2020 3ABC Financial Unveils New Software Enhancements 2ABC Financial Unveils New Software Enhancements 3
(Date:3/26/2015)... TORONTO , March 26, 2015 /PRNewswire/ - SQI ... SQIDF) announced that after dealing with certain matters, including ... of shareholders held on March 26, 2015 (the "Meeting") ... until April 8, 2015 at 11:00 a.m. ( ... Meeting has been changed from that previous disclosed. The ...
(Date:3/26/2015)... , March 26, 2015  BioNano Genomics, Inc., the ... Terry Salyer as chief commercial officer. Salyer has ... worldwide sales teams in life sciences. At BioNano, Salyer ... System, a genome-mapping platform to assemble a comprehensive view ... variations. To date, 32 institutions located in ...
(Date:3/26/2015)... -- Neogen Corporation (NASDAQ: NEOG ) announced today ... fiscal 2015, which ended Feb. 28, increased 13% to ... per share in the current quarter were $0.20, compared ... increased 17% over prior year to $24,142,000, or $0.65 ... for the same period a year ago. ...
(Date:3/26/2015)... ReliantHeart, Inc., an innovative supplier of advanced mechanical ... transit-time flow measurement solutions, are collaborating on a miniature ... the HeartAssist5® Left Ventricular Assist Device (LVAD). ... and peace of mind. , The Transonic flow ... 1/6th of the power required by earlier flow board ...
Breaking Biology Technology:SQI Diagnostics Inc. Announces Adjournment of Meeting 2BioNano Genomics Appoints Terry Salyer as Chief Commercial Officer 2BioNano Genomics Appoints Terry Salyer as Chief Commercial Officer 3Neogen reports 13% increase in net income 2Neogen reports 13% increase in net income 3Neogen reports 13% increase in net income 4Neogen reports 13% increase in net income 5Neogen reports 13% increase in net income 6Neogen reports 13% increase in net income 7Neogen reports 13% increase in net income 8LVAD patients to have greater mobility and peace of mind through Transonic and ReliantHeart’s True Flow collaboration for the HeartAssist5® 2LVAD patients to have greater mobility and peace of mind through Transonic and ReliantHeart’s True Flow collaboration for the HeartAssist5® 3
Cached News: