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Nearly two-thirds of GPs are unaware that insulin resistance, a fundamental cause of type 2 diabetes, is thought to be present in 92% of people with the disease

Nearly two-thirds of GPs are unaware that insulin resistance, a fundamental cause of type 2 diabetes, is thought to be present in 92% of people with the disease

While GPs understanding of the definition of insulin resistance is excellent (85% know it is the inability of the body to respond to its own insulin1), the number of patients that it affects is being greatly underestimated. An independent survey carried out by Taylor Nelson Sofres* has revealed that 60% of GPs and 85% of practice nurses are unaware that at least 92% of people with type 2 diabetes are insulin resistant1,2,3.

Eighty-seven percent of GPs understand that insulin resistance is related to the development of cardiovascular complications.1 However, it may be extremely difficult to optimise treatment without widespread appreciation of the prevalence of insulin resistance in type 2 diabetes.

Cardiovascular disease is the principal cause of death amongst these patients4. Treatment of insulin resistance improves glycaemic control and the UKPDS study has shown that maintenance of glycaemic control may reduce the risks of CV complications associated with type 2 diabetes5,6, comments Dr Peter Tasker of Primary Care Diabetes UK. New treatments that increase the bodys sensitivity to insulin address this problem and may therefore impact on cardiovascular risk factors. If the prevalence of insulin resistance in type 2 diabetes patients is not appreciated it could be hard to optimise treatment.

This view is supported by further survey data. Research has shown that increasing the bodys sensitivity to its own insulin using drugs such as AVANDIA (rosiglitazone) a member of the thiazolidinedione (TZD) class of oral antidiabetic agents can result in improved glycaemic control7,8. Studies have also shown that AVANDIA has positive effects on a range of cardiovascular risk factors9-13. However, the survey shows only 10% of GPs questioned would introduce a TZD in a patient found
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Contact: Becky Down
becky.down@shirehall.co.uk
44-20-7313-6300
Shire Hall Communications
5-Nov-2001


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