Nerve Cells On The Go

in called Ena--was known from other systems to bind profilin and affect actin.

The second paper exposes the other half of the pathway from the membrane downwards. It begins with Dlar, a gene causing the bypass phenotype. Dlar is a member of the receptor tyrosine phosphatase family-- membrane-spanning proteins that slice phosphate groups off other proteins inside the cell. Three years ago, Van Vactor and Haruo Saito, HMS professor of biological chemistry and molecular pharmacology, first implicated Dlar in axon guidance.

Trying to understand how Dlar signals, Van Vactor, working with graduate student Zachary Wills and others, discovered that a triumvirate of proteins--Dlar, Abl, and Ena--is bound together in intimate, antagonistic relationships. The trio makes key decisions about what information is transmitted to the cytoskeleton, Van Vactor says.

Evidence supporting that idea also comes from experiments testing the sensitivity of one protein to the dose of another. The scientists found that Dlar is as sensitive to the amount of Abl as is profilin. Halving the amount of Abl protein suppresses the damage wrought by the Dlar mutation--that is, fewer ISNb nerves bypass their targets. Conversely, increasing the amount of Abl protein beyond normal levels overwhelmed Dlar and produced the bypass phenotype in normal fly embryos, just as if they had a Dlar mutation.

This key experiment shows that the kinase Abl and the phosphatase Dlar are opposing enzymes locked in a balance of power, and each one can tip the scale. Bringing the research full circle, the scientists show that an object of this competition was the phosphate recipient Ena, the protein known to interact with profilin.

One reason this work appears complicated is that even though the researchers have established a sequence of players, they still do not fully understand the precise relationships among them.

It is not as if a valve opened at

Contact: Peta Gillyatt
Harvard Medical School

Page: 1 2 3 4

Related biology news :

1. Nerve cells guided to repair spinal damage: Technique
2. Nerves, heal thyselves
3. Nerve disorder in mice and men linked to mutated gene
4. Never too late to boogie: Nerve cells still active in mature brain
5. Nerve cells death different from other cells
6. Nerve protein shown crucial to sensations of pain from heat, injury
7. Nerve cells with stoppage: Evidence for a molecular key step in the process of signal transduction between nerve cells
8. Scientists Discover Protein In Mammals Tuned To Respond To What May Be Hottest Temperature Our Nerves Can Detect
9. Human/Insect/Jellyfish Genes Team To Quiet "Hyper" Nerve Cells
10. Small G-Proteins Make A Big Difference -- Nerve Cell Signalling Is Regulated By Arf-GTPases And Their Activators
11. How Nerve Cells Get In Touch - A Molecular Model Of Synapse Formation And Retrograde Signalling In The Brain

Post Your Comments:

(Date:8/21/2020)... (PRWEB) , ... August 20, 2020 , ... ... that Hassan Movahhed , a Clinical Operations executive with expertise in clinical ... has joined the firm as an Expert Consultant. Throughout his career, Mr. Movahhed ...
(Date:8/7/2020)... SAN FRANCISCO (PRWEB) , ... August 06, 2020 ... ... the life sciences industry, is pleased to announce that Eric Chen and Jessica ... Vice President of Product Management & Strategy, respectively. , Eric Chen heads development ...
(Date:8/3/2020)... (PRWEB) , ... August 03, 2020 , ... ... company announced a new partnership with medical equipment manufacturer, Spectrum Solutions, to provide ... clients to strengthen their laboratory supply chain for more than 10 years. Early ...
Breaking Biology News(10 mins):
(Date:7/31/2020)... ... July 29, 2020 , ... Diversified Technologies, Inc. has introduced ... configured to drive Klystrons, TWTs, IOTs, and magnetrons. , DTI Radar Transmitter ... in a push-pull configuration; yielding fast fall time for a capacitive load. These ...
(Date:7/31/2020)... (PRWEB) , ... July 30, ... ... of cloud-based software for the life sciences industry, today announced the release ... platform designed specifically for Medical Science Liaisons (MSLs) and other field medical ...
(Date:7/18/2020)... TORONTO (PRWEB) , ... July 17, 2020 , ... ... and global consulting firm for the life sciences and food industries, is pleased ... new Director of Clinical Research – Business Development. , Charles is an accomplished ...
(Date:7/7/2020)... ... ... R3 International is now offering stem cell therapy for Alzheimers dementia in Mexico ... patient's condition, treatment may be offered IV, intrathecal or with a combination. , A ... and the incidence continues to increase as individuals live longer. There is no cure, ...
Breaking Biology Technology:
Cached News: