HOME >> BIOLOGY >> NEWS
Neural development in time and space

A team of international scientists has identified a set of molecules that instructs immature neural progenitor cells ('neural stem cells') in the developing brain to produce different types of neurons at different times. As published in the latest edition of Genes and Development, this finding by Dr. Ericson and colleagues sheds new light on one of the hottest questions of developmental neuroscience: how are the many types of nerve cells in the growing brain generated?

Over the last decade, considerable progress has been made in defining mechanisms that control the generation of distinct types of neurons at different positions of the brain, whereas molecules that influence the generation of distinct neurons over time have remained unidentified. By examining the sequential generation of motor neurons and serotonergic neurons from the same pool of progenitor cells in the brainstem, the researchers were able to identify several 'transcription factors' - DNA binding proteins that regulate the expression of a particular set of genes - that control the time at which these neurons are generated. An unexpected finding was that all these factors had been implicated earlier in the spatial control of neural fate determination. "Identifying new roles to this bunch of old proteins is intriguing" says Dr. Ericson, "since it helps to demystify the time aspect of neural development and further indicates that the temporal and spatial control of neuronal differentiation must be tightly linked. It is important to stress, however, that so far we have examined only two well defined neurons in the brainstem, and it will also be necessary to examine other parts of the nervous system before we can tell if this mechanism may reflect a general principle in the establishment of neuronal cell diversity"


'"/>

Contact: Michele McDonough
mcdonoug@cshl.org
Cold Spring Harbor Laboratory
8-Mar-2003


Page: 1

Related biology news :

1. Neural stem cells take a step closer to the clinic
2. Neural biology explains ejaculation
3. Neural signal that helps wire up brains movement circuit identified
4. Neural stem cells can develop into functional neurons
5. Neural stem cells move to damaged areas of brain after injury
6. Human Neural Stem Cells Advance Distant Prospect Of Reseeding Damaged Brain
7. Cultured Neural Stem Cells Reduce Symptoms In Model Of Parkinsons Disease
8. Scientists Discover How Genes Work Together To Control Neural Development
9. Medicinal Leech May Offer Clues To Neural Regeneration
10. Bronfenbrenner book sums up human development
11. OutFoxed! New research may redefine late-stage cardiac development

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/28/2017)... , March 28, 2017 The ... Hardware (Camera, Monitors, Servers, Storage Devices), Software (Video Analytics, ... Region - Global Forecast to 2022", published by MarketsandMarkets, ... 2016 and is projected to reach USD 75.64 Billion ... and 2022. The base year considered for the study ...
(Date:3/24/2017)... 24, 2017 The Controller General of Immigration from ... Abdulla Algeen have received the prestigious international IAIR Award for the ... Continue Reading ... ... Controller Abdulla Algeen (small picture on the right) have received the IAIR ...
(Date:3/23/2017)... The report "Gesture Recognition and Touchless Sensing Market by Technology (Touch-based ... to 2022", published by MarketsandMarkets, the market is expected to be worth USD ... 2022. Continue Reading ... ... ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... and LAGUNA HILLS, Calif. , Oct. ... Cancer Research, London (ICR) and University ... SKY92, SkylineDx,s prognostic tool to risk-stratify patients with multiple myeloma ... MUK nine . The University of Leeds ... partly funded by Myeloma UK, and ICR will perform the ...
(Date:10/10/2017)... ... 2017 , ... San Diego-based team building and cooking events company, Lajollacooks4u, has ... The bold new look is part of a transformation to increase awareness, appeal to ... period. , It will also expand its service offering from its signature gourmet cooking ...
(Date:10/10/2017)... 10, 2017 International research firm Parks Associates announced ... at the TMA 2017 Annual Meeting , October 11 in ... residential home security market and how smart safety and security products impact ... Parks Associates: Smart Home ... "The residential security market has ...
(Date:10/9/2017)... DIEGO , Oct. 9, 2017  BioTech ... biological mechanism by which its ProCell stem cell ... critical limb ischemia.  The Company, demonstrated that treatment ... amount of limbs saved as compared to standard ... the molecule HGF resulted in reduction of therapeutic ...
Breaking Biology Technology:
Cached News: