HOME >> BIOLOGY >> NEWS
Neural stem cells take a step closer to the clinic

MADISON - Scientists working with cells that may someday be used to replace diseased or damaged cells in the brain have taken neural stem cell technology a key step closer to the clinic.

Writing in the current online edition (June 2003) of the Journal of Neurochemistry, scientists from the University of Wisconsin-Madison's Waisman Center describe the first molecular profile for human fetal neural stem cell lines that have been coaxed to thrive in culture for more than a year.

The work is an in-depth analysis of global gene expression in human neural stem cells and demonstrates a method for prolonging the shelf life of cultured fetal stem cells, making it possible to generate enough cells to use to treat disease, says Lynda Wright, the lead author of the paper.

"We have now characterized long-term neural stem cells lines," she says. "That genetic characterization - and our ability to grow these lines for a year or more - is one of the major steps toward clinical application."

Unlike human embryonic stem cells, stem cells derived from fetal tissue are not capable of growing in culture indefinitely. But because neural fetal stem cells have been available to science for a much longer period than cells derived from embryos, their capabilities are better known to scientists and they may reach the clinic as therapies for disorders like Parkinson's and amyotrophic lateral sclerosis (ALS) much sooner.

In culture, the cells can be coaxed into becoming "neurospheres," aggregates of precursor brain cells that, when implanted, can migrate to different parts of the brain, integrate themselves and develop into many of the different types of specialized cells that make up the brain.

"These cells are the basis for future therapies. These are the cells we want to transplant," said Clive Svendsen, senior author of the Journal of Neurochemistry paper and a leading authority on neural stem cells.

But scientists have been limited by
'"/>

Contact: Lynda Wright
wright@waisman.wisc.edu
608-263-5942
University of Wisconsin-Madison
9-Jun-2003


Page: 1 2 3

Related biology news :

1. Neural biology explains ejaculation
2. Neural development in time and space
3. Neural signal that helps wire up brains movement circuit identified
4. Neural stem cells can develop into functional neurons
5. Neural stem cells move to damaged areas of brain after injury
6. Human Neural Stem Cells Advance Distant Prospect Of Reseeding Damaged Brain
7. Cultured Neural Stem Cells Reduce Symptoms In Model Of Parkinsons Disease
8. Scientists Discover How Genes Work Together To Control Neural Development
9. Medicinal Leech May Offer Clues To Neural Regeneration
10. Preclinical safety study shows adipose-derived stem cells improve heart function after heart attack
11. Researchers develop fast track way to discover how cells are regulated

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/28/2017)... , March 28, 2017 The ... Hardware (Camera, Monitors, Servers, Storage Devices), Software (Video Analytics, ... Region - Global Forecast to 2022", published by MarketsandMarkets, ... 2016 and is projected to reach USD 75.64 Billion ... and 2022. The base year considered for the study ...
(Date:3/24/2017)... 24, 2017 The Controller General of Immigration from ... Abdulla Algeen have received the prestigious international IAIR Award for the ... Continue Reading ... ... Controller Abdulla Algeen (small picture on the right) have received the IAIR ...
(Date:3/23/2017)... The report "Gesture Recognition and Touchless Sensing Market by Technology (Touch-based ... to 2022", published by MarketsandMarkets, the market is expected to be worth USD ... 2022. Continue Reading ... ... ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... and LAGUNA HILLS, Calif. , Oct. ... Cancer Research, London (ICR) and University ... SKY92, SkylineDx,s prognostic tool to risk-stratify patients with multiple myeloma ... MUK nine . The University of Leeds ... partly funded by Myeloma UK, and ICR will perform the ...
(Date:10/10/2017)... ... 2017 , ... San Diego-based team building and cooking events company, Lajollacooks4u, has ... The bold new look is part of a transformation to increase awareness, appeal to ... period. , It will also expand its service offering from its signature gourmet cooking ...
(Date:10/10/2017)... 10, 2017 International research firm Parks Associates announced ... at the TMA 2017 Annual Meeting , October 11 in ... residential home security market and how smart safety and security products impact ... Parks Associates: Smart Home ... "The residential security market has ...
(Date:10/9/2017)... DIEGO , Oct. 9, 2017  BioTech ... biological mechanism by which its ProCell stem cell ... critical limb ischemia.  The Company, demonstrated that treatment ... amount of limbs saved as compared to standard ... the molecule HGF resulted in reduction of therapeutic ...
Breaking Biology Technology:
Cached News: