HOME >> BIOLOGY >> NEWS
Neural stem cells take a step closer to the clinic

MADISON - Scientists working with cells that may someday be used to replace diseased or damaged cells in the brain have taken neural stem cell technology a key step closer to the clinic.

Writing in the current online edition (June 2003) of the Journal of Neurochemistry, scientists from the University of Wisconsin-Madison's Waisman Center describe the first molecular profile for human fetal neural stem cell lines that have been coaxed to thrive in culture for more than a year.

The work is an in-depth analysis of global gene expression in human neural stem cells and demonstrates a method for prolonging the shelf life of cultured fetal stem cells, making it possible to generate enough cells to use to treat disease, says Lynda Wright, the lead author of the paper.

"We have now characterized long-term neural stem cells lines," she says. "That genetic characterization - and our ability to grow these lines for a year or more - is one of the major steps toward clinical application."

Unlike human embryonic stem cells, stem cells derived from fetal tissue are not capable of growing in culture indefinitely. But because neural fetal stem cells have been available to science for a much longer period than cells derived from embryos, their capabilities are better known to scientists and they may reach the clinic as therapies for disorders like Parkinson's and amyotrophic lateral sclerosis (ALS) much sooner.

In culture, the cells can be coaxed into becoming "neurospheres," aggregates of precursor brain cells that, when implanted, can migrate to different parts of the brain, integrate themselves and develop into many of the different types of specialized cells that make up the brain.

"These cells are the basis for future therapies. These are the cells we want to transplant," said Clive Svendsen, senior author of the Journal of Neurochemistry paper and a leading authority on neural stem cells.

But scientists have been limited by
'"/>

Contact: Lynda Wright
wright@waisman.wisc.edu
608-263-5942
University of Wisconsin-Madison
9-Jun-2003


Page: 1 2 3

Related biology news :

1. Neural biology explains ejaculation
2. Neural development in time and space
3. Neural signal that helps wire up brains movement circuit identified
4. Neural stem cells can develop into functional neurons
5. Neural stem cells move to damaged areas of brain after injury
6. Human Neural Stem Cells Advance Distant Prospect Of Reseeding Damaged Brain
7. Cultured Neural Stem Cells Reduce Symptoms In Model Of Parkinsons Disease
8. Scientists Discover How Genes Work Together To Control Neural Development
9. Medicinal Leech May Offer Clues To Neural Regeneration
10. Preclinical safety study shows adipose-derived stem cells improve heart function after heart attack
11. Researchers develop fast track way to discover how cells are regulated

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/11/2019)... ... 11, 2019 , ... A new report published by the Family Equality Council ... 77% of those aged 18 to 35 already have or are considering having children, ... and older.(1) Among all LGBTQ prospective parents, 41% are considering assisted reproductive technology (ART) ...
(Date:3/9/2019)... ... March 07, 2019 , ... StressMarq ... stress research tools today announced the publication of its recent PCT patent ... antibody, still at a pre-clinical stage of development, moves the company into the ...
(Date:3/5/2019)... (PRWEB) , ... March 05, 2019 , ... Join this ... how a metadata-driven approach will help data analysts and bioinformaticians focus on data analysis ... unify data that can come from different source systems. Some sources of data include:, ...
Breaking Biology News(10 mins):
(Date:3/19/2019)... Calif. (PRWEB) , ... March 19, 2019 , ... ... Konica Minolta, Inc. (Konica Minolta) today announced the formation of their inaugural Scientific ... the advancement of precision medicine that takes into account individual variability in genes, ...
(Date:3/19/2019)... Switzerland (PRWEB) , ... March ... ... at Tel HaShomer, the largest hospital in Israel and the Middle East ... manufacturing using the state-of-the-art Cocoon™ manufacturing platform. The partnership will enable Sheba ...
(Date:3/18/2019)... ... 18, 2019 , ... For more than 15 years, USDM Life Sciences ... science companies to easily comply with FDA 21 CFR Part 11 and EMA EudraLex ... service delivering end-to-end GxP compliance from vendor audit through ongoing validation maintenance, including every ...
(Date:3/14/2019)... ... March 14, 2019 , ... ... in Oklahoma City, OK. EyeCRO joins the Department of Veterans Affairs, the Oklahoma ... Center as the fifth institution in Oklahoma to receive this prestigious endorsement. ...
Breaking Biology Technology:
Cached News: