HOME >> BIOLOGY >> NEWS
New, non-radioactive screen for antimalarial compounds

Panama City, Panama, Feb. 16, 2004--Panama's International Cooperative Biodiversity Group (ICBG) announces the development of a new test for identification of antimalarial compounds with wide applicability in the developing world. The assay for plant-derived compounds also can be used to detect anti-plasmodial compounds from synthetic or natural sources. Initial results of the research are published in the American Journal of Tropical Medicine and Hygiene under the title "A Novel DNA-Based Microfluorometric Method to Evaluate Antimalarial Drug Activity".

The assay is based on fluorochrome binding to parasite double stranded DNA. Pico Green, a powerful fluorochrome developed by Invitrogen Corporation's Molecular Probes business enables detection of the malaria parasite in cell culture without the need for radioactive materials used in current methods. The new assay will be attractive in developing countries where access and disposal of radioactive tracers is prohibitively expensive as well as in the many developed-world labs that prefer non-radioactive reagents.

The new method will be attractive to researchers because it is relatively inexpensive, easy to implement in biodiverse developing countries and most importantly, safe according to Yolanda Corbett who developed the assay in Dr. Eduardo Ortega's lab: "A fluorescent DNA probe is safer and is a novel approach in the sense that red blood cells don't have DNA, so we could quantify the parasite in microtiter plates."

Malaria kills more than a million people each year in Africa alone and threatens nearly 40 percent of the world's population. The major impediment to malaria control is the cost and distribution of antimalarial drugs. Every year, antimalarial treatments become less effective as drug resistant strains of the malaria parasite develop, making the discovery of new antimalarials essential in this fight against the disease.

"The most important aspect of the wo
'"/>

Contact: Beth King
kingb@tivoli.si.edu
202-786-2094 x8216
Smithsonian Tropical Research Institute
16-Feb-2004


Page: 1 2 3

Related biology news :

1. March of Dimes statement on newborn screening report
2. Virus known for its photo ops makes its movie screen debut
3. Only 21 states offer newborn screening tests recommended by March of Dimes
4. New screening method turns up potential compound for treating anthrax
5. Gene-based screen sorts cancer cases, say Stanford researchers
6. Genome-wide screen reveals new tricks of old genes
7. Genetic screening study at Stanford IDs most aggressive adult leukemia strains
8. Genetic screening recommended to detect new neurodegenerative disorder in men over age 50
9. HPV testing could be future strategy for primary screening for cervical cancer
10. Newborn screening for certain genetic disorders has benefits and some drawbacks
11. UCSD scientists develop novel way to screen molecules

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: New non radioactive screen for antimalarial compounds

(Date:7/29/2014)... latest research from the University of Adelaide ... of many preterm children can perform almost as well as ... University,s Robinson Research Institute has found that as ... early life, their cognitive abilities as a teenager can potentially ... results of the study, published in this month,s issue of ...
(Date:7/28/2014)... U.S. Food and Drug Administration (FDA) for other purposes ... inside human cells, including those that cause Legionnaires, disease, ... mBio , the online open-access journal of the ... identifying non-antibiotic drugs that could one day help curb ... the list inhibit the growth of at least three ...
(Date:7/28/2014)... and organic compounds in hydrothermal environments are critical components ... for the deep biosphere, and may have implications for ... about how minerals influence organic reactions. A team ... a common mineral acts as a catalysts for specific ... solvents or expensive reagents. , At the heart of ...
Breaking Biology News(10 mins):Preterm children's brains can catch up years later 2New route to identify drugs that can fight bacterial infections 2Mineral magic? Common mineral capable of making and breaking bonds 2Mineral magic? Common mineral capable of making and breaking bonds 3
(Date:7/29/2014)... HOUSTON (July 29, 2014) Tough, ultralight foam ... and shape through a chemical process invented at Rice ... "GO-0.5BN" looks like a nanoscale building, with floors and ... a pair of two-dimensional materials: floors and walls of ... boron nitride platelets. , The researchers say the ...
(Date:7/29/2014)... DALLAS , July 29, 2014 ... Market Slide Scanners (Whole Slide Imaging), Analytics (Image Analysis Software), ... Storage - Global Forecasts & Trends to 2018", published ... and restraints in geographies such as North ... Asia , and the Rest of the ...
(Date:7/29/2014)... HILLS, Calif. , July 29, 2014 /PRNewswire/ ... specializing in personalized medicine, treatment of infectious diseases ... strategies of prognosis and prevention of pathologies like ... of August 1, 2014, ImmunoClin Corporation will complete ... Washington, D.C. , a key ...
(Date:7/29/2014)... 2014  Sigma-Aldrich Corporation (NASDAQ: SIAL ) ... its investment in Green Chemistry and donated more than ... year, the Company announced Monday in its new ... World? The report comes in a ... a responsible corporate citizen, including recognition for the second ...
Breaking Biology Technology:Tough foam from tiny sheets 2Digital Pathology Market worth $437 Million by 2018 2Digital Pathology Market worth $437 Million by 2018 3ImmunoClin Corporation (IMCL) Relocates Corporate Headquarters to Washington, DC 2ImmunoClin Corporation (IMCL) Relocates Corporate Headquarters to Washington, DC 3Sigma-Aldrich Achieves Record Success in Environmental, Community Initiatives 2Sigma-Aldrich Achieves Record Success in Environmental, Community Initiatives 3
Cached News: