HOME >> BIOLOGY >> NEWS
New, non-radioactive screen for antimalarial compounds

Panama City, Panama, Feb. 16, 2004--Panama's International Cooperative Biodiversity Group (ICBG) announces the development of a new test for identification of antimalarial compounds with wide applicability in the developing world. The assay for plant-derived compounds also can be used to detect anti-plasmodial compounds from synthetic or natural sources. Initial results of the research are published in the American Journal of Tropical Medicine and Hygiene under the title "A Novel DNA-Based Microfluorometric Method to Evaluate Antimalarial Drug Activity".

The assay is based on fluorochrome binding to parasite double stranded DNA. Pico Green, a powerful fluorochrome developed by Invitrogen Corporation's Molecular Probes business enables detection of the malaria parasite in cell culture without the need for radioactive materials used in current methods. The new assay will be attractive in developing countries where access and disposal of radioactive tracers is prohibitively expensive as well as in the many developed-world labs that prefer non-radioactive reagents.

The new method will be attractive to researchers because it is relatively inexpensive, easy to implement in biodiverse developing countries and most importantly, safe according to Yolanda Corbett who developed the assay in Dr. Eduardo Ortega's lab: "A fluorescent DNA probe is safer and is a novel approach in the sense that red blood cells don't have DNA, so we could quantify the parasite in microtiter plates."

Malaria kills more than a million people each year in Africa alone and threatens nearly 40 percent of the world's population. The major impediment to malaria control is the cost and distribution of antimalarial drugs. Every year, antimalarial treatments become less effective as drug resistant strains of the malaria parasite develop, making the discovery of new antimalarials essential in this fight against the disease.

"The most important aspect of the wo
'"/>

Contact: Beth King
kingb@tivoli.si.edu
202-786-2094 x8216
Smithsonian Tropical Research Institute
16-Feb-2004


Page: 1 2 3

Related biology news :

1. March of Dimes statement on newborn screening report
2. Virus known for its photo ops makes its movie screen debut
3. Only 21 states offer newborn screening tests recommended by March of Dimes
4. New screening method turns up potential compound for treating anthrax
5. Gene-based screen sorts cancer cases, say Stanford researchers
6. Genome-wide screen reveals new tricks of old genes
7. Genetic screening study at Stanford IDs most aggressive adult leukemia strains
8. Genetic screening recommended to detect new neurodegenerative disorder in men over age 50
9. HPV testing could be future strategy for primary screening for cervical cancer
10. Newborn screening for certain genetic disorders has benefits and some drawbacks
11. UCSD scientists develop novel way to screen molecules

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: New non radioactive screen for antimalarial compounds

(Date:2/5/2015)... 2015 Despite a lack of advancements ... as consumer electronics, automotive, storage and telecommunication has ... (SMT) screen printers. Innovations in electronics and conversion ... the adoption curve up. Meanwhile, sale volumes of ... dispensers are indispensable in the production of complex ...
(Date:1/22/2015)... 13, 2015  Today, FreeWavz ( www.FreeWavz.com ), the ... campaign on Fundable, https://www.fundable.com/freewavz . FreeWavz will ... capacity to meet customer demand. Logo ... http://photos.prnewswire.com/prnh/20150113/168790 Invented by Dr. ...
(Date:1/22/2015)... OXFORD, Conn. , Jan. 20, 2015 NXT-ID, Inc. (NASDAQ: ... growing mobile commerce market, reports on the recent success of the Wocket™ ... Wocket smart wallet was named as one of the ... of the "5 Best Products Launched At CES So Far" by Newseveryday.com ...
Breaking Biology News(10 mins):End-user Demand Spurs Global SMT Screen Printers and Glue Dispensers Market 2End-user Demand Spurs Global SMT Screen Printers and Glue Dispensers Market 3FreeWavz Launches on Fundable to Drive Speed-to-Market in 2015 2CES Response for NXT-ID's Wocket Smart Wallet Kicks Off 2015 2CES Response for NXT-ID's Wocket Smart Wallet Kicks Off 2015 3
(Date:2/27/2015)... 2015 The fully automated supercritical ... can sequentially analyze up to 48 samples utilizing ... detection of targets by mass spectrometry. , ... the measurement requirements of a wide range of ... delivery and search for disease biomarkers, additives in ...
(Date:2/27/2015)... February 27, 2015 FamilyFarms Group is ... Manager of State Line Farms, received the 2015 Tomorrow’s ... producer, under the age of 35, who has demonstrated ... an honor to win the Tomorrow's Top Producer Horizon ... won the Top Producer Award and learning from their ...
(Date:2/27/2015)... 27, 2015   PureTech , a science and ... disruptive products and technologies in the healthcare sector, announced ... CEO and Member of the Board of Directors of ... "It,s has been a pleasure to know Chris for ... will be working together more closely now," said Dr. ...
(Date:2/26/2015)... 2015  23andMe, the leading personal genetics company, today ... Privacy Officer and Corporate Counsel. Black brings a strong ... well as health care regulations. As a member of ... for reviewing, updating and enhancing the company,s privacy and ... She joined the company January 5, 2015 and reports ...
Breaking Biology Technology:Shimadzu Corporation Launches Nexera UC - The World’s Foremost Unified Chromatography System 2Shimadzu Corporation Launches Nexera UC - The World’s Foremost Unified Chromatography System 3Matt Sims Receives the 2015 Tomorrow’s Top Producer Horizon Award 2Christopher Viehbacher, former CEO of Sanofi, Joins PureTech's Board of Directors 2Christopher Viehbacher, former CEO of Sanofi, Joins PureTech's Board of Directors 3Christopher Viehbacher, former CEO of Sanofi, Joins PureTech's Board of Directors 423andMe Appoints Kate Black as Privacy Officer and Corporate Counsel 2
Cached News: