HOME >> BIOLOGY >> NEWS
New Class Of Synthetic Capsules That Mimic Biological Cells Has Wide Array Of Potential Uses

From individual proteins to whole tissues, scientists have been engineering or growing biological mimics for a variety of medical and industrial applications. Bioengineers from the Institute for Medicine and Engineering (IME) at the University of Pennsylvania have designed an artificial capsule that imitates many of the qualities of natural cells. The capsule - dubbed a polymersome - has wide-ranging possibilities, from a new gene-therapy delivery vehicle to an artificial red blood cell. The collaborative study between IME and the University of Minnesota describes the physical properties of the capsules. The team's findings appear in the May 14 issue of Science.

"We've created an entirely new type of synthetic capsule," says co-senior author Daniel Hammer, Ph.D., professor of chemical engineering. "The polymersomes are the same size as natural cells, but their outer membrane is much tougher than the phospholipid membrane of biological cells. And, they have the capacity to be undetectable by the human immune system so could be used to deliver all kinds of therapies to specific targets."

The capsules were produced using block copolymer chemistry. A carbon-based polymer and an organic solvent are dried on a wire. Then water is added to the system and the wire is zapped with electricity. Over time, as the polymer film lifts off the wire's surface, capsules automatically form.

"Using this method we've been able to make capsules the size of natural cells from synthetic polymers, which has never been done before," notes Dennis Discher, Ph.D., co-senior author and assistant professor of mechanical, chemical, and bioengineering. The largest artificial cell made prior to these are a micron in diameter, whereas the polymersomes range from 10 to 35 microns. Most human cells are 10 microns.

Polymersomes are also biocompatible. A chemical tag made from polyethylene oxide is used to make lipid capsules and other biological delivery vehicles invisibl
'"/>

Contact: Karen Young Kreeger
kreeger@mail.med.upenn.edu
215-614-0290
University of Pennsylvania School of Medicine
14-May-1999


Page: 1 2 3

Related biology news :

1. New Class Of Molecular Cues Guides Nervous System Wiring
2. University Of Kentucky Professor Teaches First Reproductive Laboratory Science Class In The United States
3. New Class Of Protease Inhibitors May Be Effective In Treating One Of Latin Americas Most Devastating Diseases
4. Severity Of Classic Heat Stroke Recognized
5. Rapid Progress Reported On New Class Of Anti-Cancer Drugs
6. Bacterial Protein Structure Hints At Mechanism Of A Class Of Premature Aging Diseases
7. Synthetic hormone used in contraceptives and HRT produces negative effects in monkey studies
8. Synthetic antifreeze could prevent ice growth
9. Synthetic clay could assist radioactive waste cleanup
10. Synthetic Lock Binds Some Molecules, Excludes Others
11. A Synthetic Peptide Destroys Brain Plaque Implicated in Alzheimers Disease

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/26/2019)... , ... July 25, 2019 , ... ... announced the first mixed reality headsets to include a new generation eye tracker ... Exhibition in Los Angeles, California (July 30 - August 1). SIGGRAPH attendees ...
(Date:7/21/2019)... ... July 20, 2019 , ... ... Technologies ( http://www.fluidimaging.com ) announced today the release of the biggest software ... imaging and characterization platform will provide a significant increase in productivity for ...
(Date:7/17/2019)... Pa. (PRWEB) , ... July 15, 2019 , ... ... of computational science expertise exclusively for Life Sciences and Healthcare companies, announces the ... provide critical advisory services and strategic direction to start-up and emerging bio-pharma companies ...
Breaking Biology News(10 mins):
(Date:8/14/2019)... ... August 13, 2019 , ... INDIGO Biosciences, Inc. ... solutions, announced the appointment of Mark McLoughlin to the Company’s Board of Directors. ... McLoughlin will lend his healthcare expertise and extensive background in laboratory and scientific ...
(Date:8/6/2019)... ... 06, 2019 , ... The San Diego Biotechnology Network (SDBN) ... SDBN BUZZ podcast focused on connecting the region’s biotech community and discussing topics ... the region and attract external employers, investors, scientists, and others who wish to ...
(Date:8/4/2019)... ... ... Cirtec Medical Corporation, a strategic outsourcing partner for complex medical devices, including active ... 30,000 sq. ft. manufacturing facility in the Coyol free zone, located in Alajuela, ... expected to be fully operational by the end of the year, will be the ...
(Date:7/19/2019)... ... July 18, 2019 , ... Global ... to enlarge their current piezo motion facilities in Lederhose, Germany, increasing their current ... multilayer piezo ceramic assembly production in addition to general office space, a significant ...
Breaking Biology Technology:
Cached News: