New Clue To apoE Function

St. Louis, April 28, 1998 -- Since 1992, scientists have known that people with a particular form of the protein apoE are at increased risk for developing Alzheimer's disease. They have been frustrated, however, because there has been no way to find out how the biological effects of this variant, called apoE4, differ from those of apoE3, the most common apoE in humans. Researchers at Washington University School of Medicine in St. Louis now have offered a solution by generating mice that make only human apoE3 or human apoE4. Their experiments with these mice show that apoE3 promotes nerve cell outgrowth, whereas apoE4 does not.

Most people have either two apoE3 genes, two apoE4s or one of each. The apoE2 gene is much rarer. Inheriting two apoE4s seems to be the worst luck of the draw. As well as lowering the age at which Alzheimer's disease develops, this permutation appears to speed the onset of Parkinson's disease and bodes a poor neurological outcome after cardiac bypass or cerebral hemorrhage.

"Our thinking is that apoE3 is much more effective at promoting regrowth of nerve cell extensions after injury," says David M. Holtzman, M.D., assistant professor of neurology and molecular biology & pharmacology. "Or it might be protective in the setting of brain diseases by preventing loss of connections between neurons."

Holtzman is chief author of a paper in the May 1 issue of Journal of Neuroscience. Research associate Yuling Sun, is first author.

To generate the experimental animals, Sun inserted human apoE3 or apoE4 genes into mice. Through other genetic manipulations, she made the mice express the human gene only in astrocytes, the housekeeping cells that normally make apoE in the brain. The transgenic animals then were crossed with mice that lacked the genes for mouse apoE. Eventually, the researchers obtained litters of two types. One contained pups that made no apoE plus pups that made only human apoE3. Th

Contact: Linda Sage
Washington University School of Medicine

Page: 1 2 3

Related biology news :

1. Functional genomics enables easy target identification and drives drug discovery
2. Functional food Safety aspects
3. Newly invented Endometrial Function Test (EFT®) solves the puzzle of unexplained infertility
4. Moffitt Cancer Center receives DoD funds to establish National Functional Genomics Project
5. Anthrax genome may contain new clues to fight infection, says Science Functional Genomics article
6. Function follows form in developing myocytes
7. Very-Low-Fat Diet May Compromise Immune Function, Increase Infection Risk In Trained Runners, UB Study Finds
8. Bone Marrow Gives Rise To Functioning Liver Cells, University Of Pittsburgh Scientists Discover
9. Scientists Show Proteins Function Individually As Part Of DNA Repair
10. Functional Arteries Grown From Cells Using Novel System That Simulates Fetal Environment
11. Scientists Discover Function For Type III TGF-Beta Receptor

Post Your Comments:

(Date:3/27/2021)... ... March 25, 2021 , ... Phlexglobal announced ... Planet Group, has selected Phlexglobal and its innovative regulatory SaaS software, PhlexSubmission, as ... a comprehensive review of five regulatory software companies, with the review team including ...
(Date:3/27/2021)... ... 25, 2021 , ... The 2021 Virtual Conference on Clinical Trial Supply-Europe ... More and more, clinical trial supply conferences are featuring speakers and forums that ... Asymmetrex’s founder and CEO, James L. Sherley, M.D., Ph.D., presented a talk ...
(Date:3/23/2021)... ... March 23, 2021 , ... G-CON Manufacturing (G-CON), the ... by Matica Biotechnology (Matica Bio), a contract development and manufacturing organization (CDMO) specializing ... the cleanroom build out for its new GMP production facility in College Station, ...
Breaking Biology News(10 mins):
(Date:3/27/2021)... ... March 24, 2021 , ... ... Life Sciences and Healthcare firms of all sizes, adds depth to its team ... specialist. Pardillo, who earned his doctorate in computational chemistry from Florida International University ...
(Date:3/27/2021)... ... March 24, 2021 , ... ABI Wellness, ... and reporting approach designed under CEO Mark Watson, today announced a webinar dedicated ... featuring guest speakers Dr. Cameron Clark, Neuropsychologist and Founder of Sharp Thinking, and ...
(Date:3/27/2021)... ... ... The Xtalks editorial team is pleased to announce the launch of the ... joined by editorial team members Ayesha Rashid, Sydney Perelmutter and Mira Nabulsi to discuss ... including insights from industry experts. , The Xtalks Life Science podcast will feature ...
(Date:3/23/2021)... Conn. (PRWEB) , ... March 23, 2021 , ... ... develops solutions for characterizing microbiome populations down to the strain level, recently unveiled ... applications. , Not all microbes are created equal: some are easy to ...
Breaking Biology Technology:
Cached News: