HOME >> BIOLOGY >> NEWS
New Company To Turn UNC-CH, Army Inventions Into Improved Vaccines

By ELIZABETH ZUBRITSKY
UNC-CH News Services

CHAPEL HILL -- Inventions by microbiologists at the University of North Carolina at Chapel Hill and U.S. Army Medical Research Institute of Infectious Diseases have led to creation of AlphaVax, a new company in Durham.

UNC-CH has licensed exclusively to AlphaVax four patents and two applications for patents expected to be issued. The company will develop and market the technology, which has broad applications for vaccines and gene therapy, company officials say. Initial targets include infectious diseases such as HIV -- the virus that causes AIDS -- herpes simplex virus and human papilloma virus.

Dr. Robert E. Johnston, UNC-CH professor of microbiology and immunology and one of the company's founding scientists, said the technology has obvious advantages over other vaccine methods. The new technique is efficient -- delivering large amounts of immunity-provoking substances directly to critical tissues -- and can be used multiple times in the same patient, Johnston said.

The approach grew out of research on the life cycle of the Venezuelan equine encephalitis virus done by Johnston, his UNC-CH colleague Dr. Nancy Davis and the Army institute?s Dr. Jonathan Smith. All AlphaVax scientific founders, the researchers created disarmed versions of the virus, which stimulated the immune system but did not cause disease. They also turned the attenuated virus into a vector -- a delivery vehicle that can be used for many kinds of vaccines. Unlike most vectors, however, this one can be used in the same patient several times.

"Many vectors don't work well if reused because the immune system reacts to them," said Davis, research associate professor of microbiology and immunology. "So far, in our studies in rodents, we haven't run into that problem. We're able to use our vectors for multiple vaccines or booster sh
'"/>

Contact: David L. Williamson
rdtokids@email.unc.edu
919-962-8596
University of North Carolina at Chapel Hill
22-Jan-1998


Page: 1 2

Related biology news :

1. Ferr-Damar wins 2004 Eli Lilly and Company Research Award
2. Open access initiative from the Company of Biologists
3. ESA Corporate Award winner 2001: Weyerhaeuser Company Limited British Columbia Coastal Forest Project Team
4. Warner-Lambert Company gift creates bioinformatics program
5. SFU Spin-Off Company To Research Promising Antibacterial Agents
6. New Company Formed Through Licensing Of Cardiac-Hypertrophy Technology From Texas Institutions
7. Move Over, Protein Kinase C, Youve Got Company: Munc13-1 Is A Novel Diacylglycerol Target That Modulates Neurotransmitter Release
8. Perkin-Elmer, Dr. J. Craig Venter, And TIGR Announce Formation Of New Genomics Company
9. Florida Company Using ORNL Technology For Revolutionary Wheelchair
10. Hopkins Engineering Undergrads Inventions: Power Tools For Double Amputee, Military Surveillance Robot
11. Improved nutrition could reduce malaria burden worldwide

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/13/2017)... According to a new market research report "Consumer ... Administration, and Authorization), Service, Authentication Type, Deployment Mode, Vertical, and Region - ... to grow from USD 14.30 Billion in 2017 to USD 31.75 Billion ... ... MarketsandMarkets Logo ...
(Date:4/6/2017)... , April 6, 2017 Forecasts ... ANPR, Document Readers, by End-Use (Transportation & Logistics, Government ... Oil, Gas & Fossil Generation Facility, Nuclear Power), Industrial, ... Other) Are you looking for a definitive ... ...
(Date:4/3/2017)...  Data captured by IsoCode, IsoPlexis Corporation,s ... statistically significant association between the potency of ... objective response of cancer patients post-treatment. The ... cancer patients will respond to CAR-T cell ... to improve both pre-infusion potency testing and cell ...
Breaking Biology News(10 mins):
(Date:10/10/2017)... PA (PRWEB) , ... October 10, 2017 , ... ... City Science Center’s FirstHand program has won a US2020 STEM Mentoring Award. Representatives ... the award for Excellence in Volunteer Experience from US2020. , US2020’s mission is ...
(Date:10/10/2017)... ... October 10, 2017 , ... ... 13 prestigious awards honoring scientists who have made outstanding contributions ... scheduled symposium during Pittcon 2018, the world’s leading conference and exposition for laboratory ...
(Date:10/9/2017)... (PRWEB) , ... October 09, ... ... published on October 5, 2017, in the medical journal, Epilepsia, Brain Sentinel’s ... the gold standard, video EEG, in detecting generalized tonic-clonic seizures (GTCS) using ...
(Date:10/6/2017)... ... October 06, 2017 , ... ... discussion and webinar on INSIGhT, the first-ever adaptive clinical trial for glioblastoma (GBM). ... Institute. The event is free and open to the public, but registration is ...
Breaking Biology Technology:
Cached News: