HOME >> BIOLOGY >> NEWS
New Discovery May Lead To Control Of Production Of Key Proteins

WINSTON-SALEM, N.C. -- Scientists are closing in on discovering the way that the body regulates critical proteins involved in the front line defense against disease as well as in normal body processes.

The discoveries could lead to development of pharmaceuticals to control the body's production of these proteins.

An article in the April 16 issue of Science, for the first time links the destruction of proteins to the destruction of the molecules that create those proteins, called messenger RNA. Gary Brewer, Ph.D., associate professor of microbiology and immunology at Wake Forest University Baptist Medical Center, is a co-author,

Brewer said the messenger RNAs under study encode many proteins of high interest in medicine: cytokines, which are important for immune response -- the defense against disease-- and cell development; oncoproteins, important for both normal cell growth and in the uncontrolled cell growth of cancer; and proteins that directly affect heart function.

The new results build upon previous discoveries by Brewer and his colleagues, dating back to 1986. One key discovery, in 1991, was of a protein that they called AUF1, which binds to the messenger RNA.

"It has been known for some number of years that there are enzymes that are involved in the degradation process of proteins, just as there are enzymes that are involved in the degradation process for messenger RNA," Brewer said.

One enzyme involved in the destruction of proteins is called the proteasome. "One of the implications of this work in terms of mechanism is that this protein, AUF1, binds to the RNA targeting sequences, which makes the messenger RNA unstable," Brewer said.

"How does the degradation of messenger RNA occur? What this paper would seem to indicate is that the proteasome's destruction of AUF1 somehow permits the degradation of the messenger RNA to which AUF1 is binding."

T
'"/>

Contact: Robert Conn, Mark Wright or Jim Steele
rconn@wfubmc.edu
336-716-4587
Wake Forest University Baptist Medical Center
16-Apr-1999


Page: 1 2

Related biology news :

1. Discovery of new shrimp species adds to unique family
2. Discovery of tiny microbes in ancient Greenland glacier may define limits for life on Earth
3. Discovery in parasite movement may offer insights into malaria
4. Scientists find second way to kill cancer cells: Discovery opens possibilities for new therapies
5. GlaxoSmithKline Drug Discovery and Development Research Grant Program 2004
6. Discovery helps explain how cells package DNA
7. Discovery offers clues to origin of life
8. Discovery could improve anemia treatment in patients
9. Discovery could lead to better treatment for cryptosporidum infections
10. Discovery of brain disorder gene paves way for genetic test
11. Discovery may be first plant cell surface molecule that halts cell proliferation

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/26/2019)... ... 25, 2019 , ... The team at Cieplak Dental Excellence ... myofunctional disorders (OMDs) are abnormal movement patterns of the face and mouth that ... from difficulty swallowing and limited tongue movement to an overbite. Participation in this ...
(Date:10/22/2019)... ... 2019 , ... Greenberg Traurig, LLP’s global Life Sciences & ... the Life Sciences Sector,” with German biotech strategy consulting firm, Catenion. The seminar will ... Tokyo office . , Speakers from Greenberg Traurig and Catenion will discuss best ...
(Date:10/17/2019)... HOUSTON, Texas (PRWEB) , ... October 15, 2019 ... ... engineering firm, is pleased to announce it made its first appearance on the ... two-year revenue growth of 56 percent. , With corporate headquarters in Houston, ...
Breaking Biology News(10 mins):
(Date:10/30/2019)... ... October 30, 2019 , ... Western ... many roles innovation and technology play in educating the next generation of health ... learning opportunities and presentations by WesternU administrators and representatives of companies working with ...
(Date:10/29/2019)... ... October 29, 2019 , ... Modality Solutions, a ... cold chain validation workshop at the Biomanufacturing World Summit (BMWS19) Conference, November 11-12, ... The Biomanufacturing World Summit brings together pharmaceutical executives, cutting-edge technology providers, ...
(Date:10/26/2019)... ... 2019 , ... Sparks Marketing Group, Inc. (Sparks) ... boutique healthcare-specific marketing firm, to strengthen the agency’s growing focus on the healthcare ... clients in pharma, bio-therapeutics, medical device and healthcare technologies currently account for a ...
(Date:10/22/2019)... (PRWEB) , ... October 22, 2019 , ... Catalent, a ... Supply Services and Drug Product Technologies Integration, will participate in a panel session titled ... (HPCLC), to be held at the Gwen Hotel, Chicago, on Oct. 28-30, 2019. , ...
Breaking Biology Technology:
Cached News: