New Evidence On How Prions Turn Fatal

Structure Suggests Possibility of Breeding Animals Resistant to 'Mad Cow Disease'

University of California researchers say a newly determined structure of the biological particles called prions may help explain how they cause infectious deadly diseases. Aberrant prions cause scrapie in sheep, bovine spongiform encephalopathy (BSE or "mad cow disease") in cows, and various afflictions in people. The scientists say their finding might also explain prion disease variety and eventually lead to breeding disease-resistant animals.

The research is detailed in the peer-reviewed journal Biochemistry, published by the American Chemical Society (ACS), the world's largest scientific society. It is being released on the ACS Web April 9 and appears in the print edition of the journal on April 27.

Prions are proteins normally found in the brain of all animals. Changes in their three-dimensional structure can cause infectious, fatal neurodegenerative disorders. Further, altered prions seem to act as templates that convert normal prions to the infectious form. Relatively few people suffer from prion diseases, but they cause large problems in sheep flocks and cattle herds. The disease rarely passes between species, but there is evidence that people can be infected by eating tainted beef.

The economic and political consequences of such scares have made understanding the novel mechanisms of prion diseases a very visible quest. Dr. Stanley B. Prusiner, from the University of California at San Francisco (UCSF), was awarded the 1997 Nobel Prize in Physiology or Medicine for discovering prions. He is a collaborator on the current Biochemistry paper.

"Our structural studies show that an important part of the prion protein exhibits multiple structures," according to co-author and UCSF pharmaceutical chemist Thomas L. James, Ph.D. He says that specific area "marks the region susceptible to the structural change from the normal cellular form

Contact: Charmayne Marsh
American Chemical Society

Page: 1 2

Related biology news :

1. Evidence builds for potential new cancer drug target
2. Evidence for sympatric speciation by host shift in the sea
3. Evidence for the impact of climate change on deep-sea biodiversity
4. Evidence for fat hormone target in brain
5. Evidence of nanobacterial-like structures found in human calcified arteries and cardiac valves
6. Evidence shows the heart has stem cells able to regenerate muscle tissue lost to disease, wear
7. Evidence for orangutan culture
8. Evidence suggests that standard smallpox vaccine offers long-term immunity
9. Evidence that adults stem cells differentiate like embryonic stem cells published in Nature
10. When Shewanella meets goethite: Evidence found of recognition between animate and inanimate objects
11. Evidence links protein damage to Parkinsons

Post Your Comments:

(Date:12/19/2018)... ROCHELLE, Va. (PRWEB) , ... December 19, 2018 , ... ... former Scientific Reviewer and Compliance Officer at the FDA Center for Devices and Radiological ... with NDA Partners as an Expert Consultant since 2015, and she has more than ...
(Date:12/18/2018)... ... December 18, 2018 , ... The nation’s leader in ... marketing. The technology has been effective at reducing patient acquisition costs by over ... with clients nationwide on patient acquisition marketing programs. Traditional marketing for stem cell ...
(Date:12/14/2018)... (PRWEB) , ... December 14, 2018 , ... ... patent number 9,703,929 entitled “Method and System for Microbiome-Derived Diagnostics and Therapeutics” by ... date of October 21, 2014. The patent is an invention by uBiome collaborators ...
Breaking Biology News(10 mins):
(Date:12/13/2018)... FREDERICK, Md. (PRWEB) , ... December 12, 2018 ... ... RFID and other life science software solutions, announces the Limfinity® ML (Machine Learning) ... to integrate trained machine learning models within Limfinity® solutions. In the module, trained ...
(Date:12/10/2018)... China and SAN DIEGO (PRWEB) , ... ... ... MabPlex International, Ltd., a fully integrated Contract Development and Manufacturing Organization (CDMO) ... development, process characterization, conjugation optimization, cGMP manufacturing, and aseptic fill finish solutions ...
(Date:12/5/2018)... ... December 05, 2018 , ... STRmix™ – sophisticated forensic ... interpret – has been used to convict a Wyoming man of third-degree sexual assault, ... Laboratory used STRmix™ to test for DNA on the couch cushions on which the ...
(Date:11/28/2018)... ... , ... Earlier this month, Lajollacooks4u's Founder and Chef Jodi Abel traveled to ... truffle season. , Her first stop was Umbria, a region in Central ... Truffle Lodge in the small mountain village of Pettino, Chef Jodi was introduced to ...
Breaking Biology Technology:
Cached News: