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New Gene Holds Promise For Controlling Crohn's And Other Inflammatory Diseases

Researchers At Boston University Goldman School Of Dental Medicine Discover New Gene

(Boston, MA) - A new gene involved in common inflammatory diseases, like rheumatoid arthritis and Crohn's disease, was recently discovered by scientists at Boston University's School of Dental Medicine.

The scientists identified the gene that controls production of Tumor Necrosis Factor alpha (or TNF), a molecule the body produces when it needs to destroy unwanted tissues -when it is fighting infection, for example. The researchers believe that this molecule is also implicated in a wide variety of inflammatory diseases - diseases in which the body literally attacks itself - including periodontal disease, septic shock, rheumatoid arthritis, lupus, Crohn's disease, and diabetes.

"We believe this discovery offers new insights into how the body regulates the fundamental pathway involved in inflammation and opens up new ways to find and to treat currently untreatable diseases, " explains Dr. Salomon Amar, Associate Professor of Oral Biology and Periodontology at Boston University's School of Dental Medicine. Amar led a team of four researchers at the Boston University School of Dental Medicine and School of Medicine.

The scientists deleted portions of the promoter of the TNF gene and tested whether or not the gene continued to function. They found that if a particular sequence were removed, cells could not produce TNF. Further, they found that this sequence bound a previously unknown transcription factor - a molecule that regulates other molecules like TNF that exert a powerful effect on the body. They named this molecule LITAF (lipopolysaccharide-induced transcription factor).

Anti-TNF therapies for Crohn's disease are under development by pharmaceutical companies, however the protein molecules under development are too expensive and too difficult to administer to be ideal for the long-term therapy necessary for chronic conditions like Crohn's dise
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Contact: Joan Schwartz
joschwar@bu.edu
617-353-4626
Boston University
25-May-1999


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