HOME >> BIOLOGY >> NEWS
New Gene Therapy Strategy Keeps Muscles Strong In Old Age: Possibilities Seen For Disease Treatment, But Also For Athletic Or Cosmetic Enhancements

Scientists at the University of Pennsylvania Medical Center have developed a novel gene therapy treatment that permanently blocks the age-related loss of muscle size and strength in mice. Mice, like humans and all mammals, lose up to a third of their muscle mass and power with age. In humans, the result is an advancing weakness in the elderly that can lead to unsteadiness and impaired mobility, increased susceptibility to falls and injury, and joint stress and degeneration.

Even in young adult mice, the new treatment increased muscle strength by a dramatic 15 percent over untreated muscle. But in older mice, the improvement was even more remarkable: The researchers documented a 27 percent increase in strength over untreated muscle in these mice -- fully restoring their strength to what it was in young adulthood.

The technique suggests human therapies that could reverse the feebleness associated with old age or counter the muscle-wasting effects of muscular dystrophies and related diseases. It also raises the possibility, however, that the technique could be used -- or abused -- for athletic or cosmetic enhancements.

Results from the experimental study will be presented at the 38th annual meeting of the American Society for Cell Biology in San Francisco on December 14 and will be published in the December 22 issue of the Proceedings of the National Academy of Sciences. (Copies of the paper are available to reporters through the journal's news office, reachable by telephone at 202-334-2138 or by e-mail at pnasnews@nas.edu.)

"Our results show that it may be possible to preserve muscle size and strength in old age using this approach," says H. Lee Sweeney, PhD, professor of physiology and senior investigator on the study. "We're now looking to see whether the technique might also be used to increase muscle strength in diseases such as muscular dystrophy."

To de
'"/>

Contact: hokef@mail.med.upenn.edu
hokef@mail.med.upenn.edu
215-349-5659
University of Pennsylvania School of Medicine
14-Dec-1998


Page: 1 2 3

Related biology news :

1. 1st International Conference on Cell Therapy for Cardiovascular Disease
2. National Cancer Gene Therapy Foundation gives $4.0 million in research grants
3. Braunschweig Prize 2003 for Molecular Cancer Therapy
4. Alliance for Cancer Gene Therapy announces $1.5 million in national grants to young investigators
5. New research on safety of intracoronary delivery of adenovector reported in cover story of Molecular Therapy
6. Therapy hinders AIDS virus from evolving drug resistance, Hopkins researchers find
7. Invitation To Cover: American Society Of Gene Therapy Meeting
8. Gene Therapy For Pain
9. Role Of Protein Linked To Colon Cancer Identified, Offering Potential Target For Therapy
10. Shock Therapy Exceeds Expectations In Cleaning Up Contaminated Soils
11. Penn Researchers Develop Gene Therapy Technique That Reverses Muscle Membrane Weakness In Muscular Dystrophy Variant

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:11/7/2018)... ... November 07, 2018 , ... John Powers, co-founder and President ... is pleased to announce that Gene Tox Lab Solutions, LLC has been admitted ... help healthcare organizations including hospitals and clinics manage their patient population through specialized ...
(Date:11/7/2018)... Mass. (PRWEB) , ... November 07, 2018 , ... ... special requests, and the flexibility to adjust to last-minute changes all contribute to ... Colpitts Clinical. The clinical trial patient travel and expense services provider says 80 ...
(Date:11/7/2018)... ... November 07, 2018 , ... ... solutions, announced today a modernized and streamlined White Label Program. This enhancement delivers ... newly established reseller administrative control portal. CallTower enhanced their white label program to ...
Breaking Biology News(10 mins):
(Date:11/5/2018)... ... November 05, 2018 , ... ... educational support for healthcare professionals through its website, http://www.glycomark.com , as part ... live chat and video option via the website in November from 9 a.m. ...
(Date:11/3/2018)... ... ... Triangle Insights Group, a premier life sciences consulting firm, announced today that ... the United States, appearing on this year’s Inc. 5000 list. Since its inception ... over the previous three years. , Separately, Triangle Insights was also ranked on ...
(Date:10/31/2018)... ... ... young Labrador retriever. Like most labs, Pippa is energetic, crazy, and fun-loving. When ... in her right knee. According to her mom, Kinsley, Pippa was limping constantly and ... heart to see Pippa lie around in pain because it hurt too much to play. ...
(Date:10/29/2018)... ... October 29, 2018 , ... PracticeMatch , a ... released its schedule of physician career fairs planned for 2019. The company has expanded ... hosting live events in the areas of the country which have the highest concentrations ...
Breaking Biology Technology:
Cached News: