HOME >> BIOLOGY >> NEWS
New Gladstone/UCSF study finds inhibiting fat synthesis results in obesity resistance in mice

The regulation of fat mass in the body appears to be more complicated than previously thought, according to new study findings. Researchers from the Gladstone Institute of Cardiovascular Disease and the University of California, San Francisco report their findings in the May issue of Nature Genetics.

One key step in fat regulation is the production, or synthesis, of triglycerides, the major component of fat and stored energy in mammals. This process is carried out by an enzyme called DGAT, for acyl CoA:diacylglycerol acyltransferase.

It might be expected that when DGAT is not present, triglycerides are not produced, but a Gladstone/UCSF team found this is not the case. In studies with mice, the researchers inactivated the gene that produces DGAT, then compared these animals with their normal cousins. They found that the DGAT-deficient mice produced less triglycerides than normal mice, but were still healthy. (A certain level of fat in body tissues is critical to good health and survival.)

When normal mice were fed a high-fat diet, they became obese. The DGAT-deficient mice, however, were lean and resistant to diet-induced obesity. Moreover, they had a higher metabolic rate and expended more energy, in part because they were more active. DGAT-deficiency also affected metabolism in other tissues, including causing an impairment in milk production in females. "Our findings indicate that multiple mechanisms exist for triglyceride synthesis, rather than a single mechanism as previously thought. They also suggest that specifically blocking DGAT-mediated triglyceride synthesis may be a potential strategy for treating obesity," said senior study investigator Robert V. Farese, Jr., MD, Gladstone scientist and UCSF Associate Professor of Medicine.


'"/>

Contact: Corinna Kaarlela
ckaarlela@pubaff.ucsf.edu
415-476-3804
University of California - San Francisco
30-Apr-2000


Page: 1

Related biology news :

1. Gladstone/UCSF team discovers interaction of two brain proteins may be key factor in development of Alzheimers disease
2. Student science contest participation influences study, career choices, alumni say
3. New study shows hope for treating inhalant abuse
4. International study findings link acne-like rash to effectiveness of new targeted cancer treatment
5. Cigarette smoke causes breaks in DNA and defects to a cells chromosomes, Pitt study finds
6. New study indicates arsenic could be suitable as first-line treatment in type of leukaemia
7. Phase II trials of second-generation antisense cancer drug planned following successful early study
8. Preclinical safety study shows adipose-derived stem cells improve heart function after heart attack
9. Indiana University, EPA to study airborne PCBs
10. K-State, other universities to study how climate affects plant evolution
11. USC study links historical increases in life span to lower childhood exposure to infection

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/3/2016)... -- Vigilant Solutions announces today that the ... solved two recent hit-and-run cases with the ... Solutions. Brian Wenberg explains, "I was ... out of a convenience store and witnessed an elderly male back out ... his vehicle and leaving the scene.  In his statement ...
(Date:2/2/2016)... , Feb. 2, 2016 Checkpoint ... that Rising Market Are you interested in ... forecasts revenues for checkpoint inhibitors. Visiongain,s report gives ... submarket, product and national level. Avoid falling ... what progress, opportunities and revenues those emerging cancer ...
(Date:2/1/2016)... -- Rising sales of consumer electronics coupled ... gesture control market size through ... electronics coupled with new technological advancements to drive global ... through 2020   --> Rising ... to drive global touchfree intuitive gesture control market ...
Breaking Biology News(10 mins):
(Date:2/9/2016)... , Feb. 9, 2016 This market ... the current and future prospects of the market in ... report include companies engaged in the manufacture of microbiology ... executive summary with a market snapshot providing the overall ... of this report. This section also provides the overall ...
(Date:2/9/2016)... , February 9, 2016 Three-Year ... Enables Children to Take Part in Life-Changing Camp ... new initiative designed to positively affect the lives of children born ... care. --> SHPG ) is announcing a new initiative ... diseases, as well as the future of rare disease care. ...
(Date:2/9/2016)... LONDON , Feb. 9, 2016 /PRNewswire/ ... (PTP1B) Inhibitors-Pipeline Insights, 2016", report provides in ... their development activities around the Protein-Tyrosine Phosphatase ... the product profiles in various stages of ... Phase II, Phase III and Preregistration. Report ...
(Date:2/8/2016)... 2016 Should antibiotic bone cement products be ... prevent infection after standard total hip or knee replacement ... Institute have been fielding a lot lately. ... Line?" --> "Antibiotic Bone Cement: ... --> While there isn,t a simple answer, ...
Breaking Biology Technology:
Cached News: