HOME >> BIOLOGY >> NEWS
New Gladstone/UCSF study finds inhibiting fat synthesis results in obesity resistance in mice

The regulation of fat mass in the body appears to be more complicated than previously thought, according to new study findings. Researchers from the Gladstone Institute of Cardiovascular Disease and the University of California, San Francisco report their findings in the May issue of Nature Genetics.

One key step in fat regulation is the production, or synthesis, of triglycerides, the major component of fat and stored energy in mammals. This process is carried out by an enzyme called DGAT, for acyl CoA:diacylglycerol acyltransferase.

It might be expected that when DGAT is not present, triglycerides are not produced, but a Gladstone/UCSF team found this is not the case. In studies with mice, the researchers inactivated the gene that produces DGAT, then compared these animals with their normal cousins. They found that the DGAT-deficient mice produced less triglycerides than normal mice, but were still healthy. (A certain level of fat in body tissues is critical to good health and survival.)

When normal mice were fed a high-fat diet, they became obese. The DGAT-deficient mice, however, were lean and resistant to diet-induced obesity. Moreover, they had a higher metabolic rate and expended more energy, in part because they were more active. DGAT-deficiency also affected metabolism in other tissues, including causing an impairment in milk production in females. "Our findings indicate that multiple mechanisms exist for triglyceride synthesis, rather than a single mechanism as previously thought. They also suggest that specifically blocking DGAT-mediated triglyceride synthesis may be a potential strategy for treating obesity," said senior study investigator Robert V. Farese, Jr., MD, Gladstone scientist and UCSF Associate Professor of Medicine.


'"/>

Contact: Corinna Kaarlela
ckaarlela@pubaff.ucsf.edu
415-476-3804
University of California - San Francisco
30-Apr-2000


Page: 1

Related biology news :

1. Gladstone/UCSF team discovers interaction of two brain proteins may be key factor in development of Alzheimers disease
2. Student science contest participation influences study, career choices, alumni say
3. New study shows hope for treating inhalant abuse
4. International study findings link acne-like rash to effectiveness of new targeted cancer treatment
5. Cigarette smoke causes breaks in DNA and defects to a cells chromosomes, Pitt study finds
6. New study indicates arsenic could be suitable as first-line treatment in type of leukaemia
7. Phase II trials of second-generation antisense cancer drug planned following successful early study
8. Preclinical safety study shows adipose-derived stem cells improve heart function after heart attack
9. Indiana University, EPA to study airborne PCBs
10. K-State, other universities to study how climate affects plant evolution
11. USC study links historical increases in life span to lower childhood exposure to infection

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/18/2017)... April 18, 2017  Socionext Inc., a global expert in SoC-based ... edge server, the M820, which features the company,s hybrid codec technology. ... by Tera Probe, Inc., will be showcased during the upcoming Medtec ... show at the Las Vegas Convention Center ... Click here ...
(Date:4/13/2017)... April 13, 2017 According to a new market ... Identity Analytics, Identity Administration, and Authorization), Service, Authentication Type, Deployment Mode, Vertical, ... Market is expected to grow from USD 14.30 Billion in 2017 to ... of 17.3%. ... MarketsandMarkets Logo ...
(Date:4/11/2017)... 11, 2017 No two people are ... the New York University Tandon School of Engineering ... found that partial similarities between prints are common ... mobile phones and other electronic devices can be ... vulnerability lies in the fact that fingerprint-based authentication ...
Breaking Biology News(10 mins):
(Date:7/18/2017)... ... July 18, 2017 , ... Recently recognized ... https://dataformsoftware.com ) announces the migration of its flagship cloud-based product Planet Life Cycle ... team-centric, enterprise work management system that merges strategic and financial planning with execution. ...
(Date:7/17/2017)... ... July 17, 2017 , ... ... solutions, today announced safety software company AB Cube has joined its ... segment to advance technology innovation across life sciences and healthcare. Under the ...
(Date:7/17/2017)... ... 17, 2017 , ... Panitch Schwarze Belisario & Nadel ... BiG (Biomedical Innovation Group) annual meeting in China. , This year’s meeting, held ... T-cell) therapy, a rapidly developing highly personalized anti-cancer technology that involves removing some ...
(Date:7/16/2017)... ... July 16, 2017 , ... ... analytical instruments announced the launch of its new line of Rocking and Waving ... and waving shaker models (both analog and digital) for laboratory applications in a ...
Breaking Biology Technology:
Cached News: