HOME >> BIOLOGY >> NEWS
New Gladstone/UCSF study finds inhibiting fat synthesis results in obesity resistance in mice

The regulation of fat mass in the body appears to be more complicated than previously thought, according to new study findings. Researchers from the Gladstone Institute of Cardiovascular Disease and the University of California, San Francisco report their findings in the May issue of Nature Genetics.

One key step in fat regulation is the production, or synthesis, of triglycerides, the major component of fat and stored energy in mammals. This process is carried out by an enzyme called DGAT, for acyl CoA:diacylglycerol acyltransferase.

It might be expected that when DGAT is not present, triglycerides are not produced, but a Gladstone/UCSF team found this is not the case. In studies with mice, the researchers inactivated the gene that produces DGAT, then compared these animals with their normal cousins. They found that the DGAT-deficient mice produced less triglycerides than normal mice, but were still healthy. (A certain level of fat in body tissues is critical to good health and survival.)

When normal mice were fed a high-fat diet, they became obese. The DGAT-deficient mice, however, were lean and resistant to diet-induced obesity. Moreover, they had a higher metabolic rate and expended more energy, in part because they were more active. DGAT-deficiency also affected metabolism in other tissues, including causing an impairment in milk production in females. "Our findings indicate that multiple mechanisms exist for triglyceride synthesis, rather than a single mechanism as previously thought. They also suggest that specifically blocking DGAT-mediated triglyceride synthesis may be a potential strategy for treating obesity," said senior study investigator Robert V. Farese, Jr., MD, Gladstone scientist and UCSF Associate Professor of Medicine.


'"/>

Contact: Corinna Kaarlela
ckaarlela@pubaff.ucsf.edu
415-476-3804
University of California - San Francisco
30-Apr-2000


Page: 1

Related biology news :

1. Gladstone/UCSF team discovers interaction of two brain proteins may be key factor in development of Alzheimers disease
2. Student science contest participation influences study, career choices, alumni say
3. New study shows hope for treating inhalant abuse
4. International study findings link acne-like rash to effectiveness of new targeted cancer treatment
5. Cigarette smoke causes breaks in DNA and defects to a cells chromosomes, Pitt study finds
6. New study indicates arsenic could be suitable as first-line treatment in type of leukaemia
7. Phase II trials of second-generation antisense cancer drug planned following successful early study
8. Preclinical safety study shows adipose-derived stem cells improve heart function after heart attack
9. Indiana University, EPA to study airborne PCBs
10. K-State, other universities to study how climate affects plant evolution
11. USC study links historical increases in life span to lower childhood exposure to infection

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/9/2017)... Australia , March 9, 2017 4Dx ... prestigious World Lung Imaging Workshop at the University of ... was invited to deliver the latest data to world ... recognised event brings together leaders at the forefront of ... in lung imaging. "The quality of ...
(Date:3/6/2017)... , March 6, 2017 Mintigo ... technology, today announced Predictive Sales Coach TM , ... actionable sales intelligence into Salesforce. This unique AI ... their sales organizations with deep knowledge of their ... for intelligent engagement. Predictive Sales Coach extends Mintigo,s ...
(Date:3/2/2017)... Australia , March 2, 2017 Australian ... Ltd (ASX: CYP), has signed an agreement with ... from the Monash Biomedicine Discovery Institute and Department of ... to conduct a further preclinical study to support the ... treatment of asthma.  Asthma is a ...
Breaking Biology News(10 mins):
(Date:3/27/2017)... Properties (NYSE: CUZ ) announced today that Amgen, ... 10-year, approximately 125,000 square-foot lease at Corporate Center, a 1,224,000 ... submarket of Tampa, FL. ... for their new location in Tampa ," ... of Cousins Properties. "Amgen is a cutting-edge global company at ...
(Date:3/27/2017)... DUBLIN , March 27, 2017 ... access to a comprehensive library of reports on Valero ... the transportation fuels and petrochemical industries. ...      (Logo: http://photos.prnewswire.com/prnh/20160330/349511LOGO) ... is biofuel production to go green. Ethanol today, even though ...
(Date:3/27/2017)... NEW YORK , March 27, 2017 /PRNewswire/ ... company developing novel therapies for neurodegenerative diseases, including ... confirmation that its application to list the Company,s ... been approved by The NASDAQ Stock Market, a ... of the listing, Neurotrope will ring the Opening Bell ...
(Date:3/24/2017)... 24, 2017 On Thursday, March ... at 5,817.69, down 0.07%; the Dow Jones Industrial Average ... S&P 500 closed at 2,345.96, marginally dropping 0.11%. US ... in green, 4 sectors finished in red, and 1 ... has initiated reports coverage on the following Biotechnology equities: ...
Breaking Biology Technology:
Cached News: