HOME >> BIOLOGY >> NEWS
New Gladstone/UCSF study finds inhibiting fat synthesis results in obesity resistance in mice

The regulation of fat mass in the body appears to be more complicated than previously thought, according to new study findings. Researchers from the Gladstone Institute of Cardiovascular Disease and the University of California, San Francisco report their findings in the May issue of Nature Genetics.

One key step in fat regulation is the production, or synthesis, of triglycerides, the major component of fat and stored energy in mammals. This process is carried out by an enzyme called DGAT, for acyl CoA:diacylglycerol acyltransferase.

It might be expected that when DGAT is not present, triglycerides are not produced, but a Gladstone/UCSF team found this is not the case. In studies with mice, the researchers inactivated the gene that produces DGAT, then compared these animals with their normal cousins. They found that the DGAT-deficient mice produced less triglycerides than normal mice, but were still healthy. (A certain level of fat in body tissues is critical to good health and survival.)

When normal mice were fed a high-fat diet, they became obese. The DGAT-deficient mice, however, were lean and resistant to diet-induced obesity. Moreover, they had a higher metabolic rate and expended more energy, in part because they were more active. DGAT-deficiency also affected metabolism in other tissues, including causing an impairment in milk production in females. "Our findings indicate that multiple mechanisms exist for triglyceride synthesis, rather than a single mechanism as previously thought. They also suggest that specifically blocking DGAT-mediated triglyceride synthesis may be a potential strategy for treating obesity," said senior study investigator Robert V. Farese, Jr., MD, Gladstone scientist and UCSF Associate Professor of Medicine.


'"/>

Contact: Corinna Kaarlela
ckaarlela@pubaff.ucsf.edu
415-476-3804
University of California - San Francisco
30-Apr-2000


Page: 1

Related biology news :

1. Gladstone/UCSF team discovers interaction of two brain proteins may be key factor in development of Alzheimers disease
2. Student science contest participation influences study, career choices, alumni say
3. New study shows hope for treating inhalant abuse
4. International study findings link acne-like rash to effectiveness of new targeted cancer treatment
5. Cigarette smoke causes breaks in DNA and defects to a cells chromosomes, Pitt study finds
6. New study indicates arsenic could be suitable as first-line treatment in type of leukaemia
7. Phase II trials of second-generation antisense cancer drug planned following successful early study
8. Preclinical safety study shows adipose-derived stem cells improve heart function after heart attack
9. Indiana University, EPA to study airborne PCBs
10. K-State, other universities to study how climate affects plant evolution
11. USC study links historical increases in life span to lower childhood exposure to infection

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/21/2016)... 21, 2016 NuData Security announced today that ... of principal product architect and that Jon ... customer development. Both will report directly to ... moves reflect NuData,s strategic growth in its product ... customer demand and customer focus values. ...
(Date:6/15/2016)... ALBANY, New York , June 15, 2016 ... published a new market report titled "Gesture Recognition Market ... Trends and Forecast, 2016 - 2024". According to the ... at USD 11.60 billion in 2015 and is ... and reach USD 48.56 billion by 2024.  ...
(Date:6/7/2016)... , June 7, 2016  Syngrafii Inc. and ... business relationship that includes integrating Syngrafii,s patented LongPen™ ... project. This collaboration will result in greater convenience ... credit union, while maintaining existing document workflow and ... ...
Breaking Biology News(10 mins):
(Date:11/30/2016)... , November 30, 2016 The global ... few players hold a dominant share in the overall ... Laboratories International, Inc., and Merck KGaA, held a lion,s ... Transparency Market Research observes that these companies are expected ... development products that are do not require rabbit pyrogen ...
(Date:11/30/2016)... VANCOUVER , Nov. 30, 2016 /PRNewswire/ -  Equicare ... coordination solutions, has been recognized as one of the ... 100, an annual international listing that distinguishes the top ... "We,ve pushed a great step forward this year continually ... growing our own customer base and team," says ...
(Date:11/30/2016)... -- Part of 5m$ Investment in Integrated Drug ... , ... today announced that it had successfully completed the expansion of ... increased the Screening Collection to over 400,000. The new compounds ... the company. This expansion, complemented by new robotics and compound ...
(Date:11/30/2016)... Triangle Park, NC (PRWEB) , ... November 30, ... ... development company engaged in the development of a new orally administered treatment for ... testing and neuroimaging results of a Phase 2a clinical trial of T3D-959 in ...
Breaking Biology Technology:
Cached News: