HOME >> BIOLOGY >> NEWS
New Hair in 15 Days

Scientists at the University of Michigan Medical School have discovered that the transient activation of a protein called -catenin can induce new hair growth.

The study is published in the May 15th issue of Genes & Development.

Adult hair follicles undergo a growth cycle consisting of periods of growth (anagen), regression (catagen), and rest (telogen). David Van Mater and colleagues (Drs. Frank Kooligs, Andrzej Dlugosz, and Eric Fearon) at the University of Michigan have demonstrated that the brief activation of -catenin in telogen-phase adult hair follicles is sufficient to initiate the anagen phase.

The -catenin protein is a key member of the Wnt signal transduction cascade, an important intracellular signaling pathway. The canonical Wnt signaling pathway involves the stabilization of -catenin protein, its subsequent accumulation in the cell, and its activation of Wnt target genes. Previous work has implicated Wnt/-catenin signaling in embryonic hair follicle development, postnatal follicle growth and maturation, and skin tumor formation. This new work provides important insight into the role of -catenin as a trigger for activating the normal growth of adult hair follicles.

The University of Michigan researchers generated transgenic mice expressing an inactive version of -catenin in their skin and hair follicles. Upon topical treatment of the mice with a chemical called 4-OHT, the exogenous -catenin protein is activated. Thus, through the cutaneous application of 4-OHT, the researchers could transiently activate -catenin signaling at will.

To test the effect of -catenin signaling on adult hair growth, the researchers shaved the backs of telogen-phase transgenic and wild-type mice, and then applied 4-OHT once. Within 15 days, the transgenic mice grew new hair, whereas wild-type still had none (see accompanying image). Furthermore, the new hair was histologically indistinguishable from normal hair, and progressed through the
'"/>

Contact: Heather Cosel
coselpie@cshl.org
Cold Spring Harbor Laboratory
14-May-2003


Page: 1 2

Related biology news :

1. Bone marrow cells routinely help with wound healing
2. Gene therapy tested to protect bone marrow during chemotherapy
3. Umbilical cord blood transplants, bone marrow transplants save lives
4. Dampened hopes for transplanting bone marrow stem cells in heart attacks
5. Cells from adult bone marrow can be converted into brain stem cells for transplantation
6. Chromosome caps predict bone marrow disease
7. Researchers look to stem cell therapy and bone marrow transplants to find a cure for diabetes
8. Scientists uncover novel role for estrogen in bone marrow
9. Transparent fish provide window on blood formation and marrow transplantation
10. Bone marrow fusion with nerve cells may repair damage, Stanford researchers say
11. UCSF-led study raises doubts about marrow cell treatment for brain, heart

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/11/2017)... 11, 2017 NXT-ID, Inc. (NASDAQ:   ... announces the appointment of independent Directors Mr. Robin D. ... Board of Directors, furthering the company,s corporate governance and expertise. ... Gino Pereira , ... forward to their guidance and benefiting from their considerable expertise ...
(Date:4/4/2017)...   EyeLock LLC , a leader of iris-based ... Patent and Trademark Office (USPTO) has issued U.S. Patent ... an iris image with a face image acquired in ... 45 th issued patent. "The ... the multi-modal biometric capabilities that have recently come to ...
(Date:3/29/2017)... 2017  higi, the health IT company that operates ... America , today announced a Series B investment ... EveryMove. The new investment and acquisition accelerates higi,s strategy ... transform population health activities through the collection and workflow ... higi collects and secures data today on behalf of ...
Breaking Biology News(10 mins):
(Date:10/9/2017)... 2017  BioTech Holdings announced today identification and ... ProCell stem cell therapy prevents limb loss in ... demonstrated that treatment with ProCell resulted in more ... compared to standard bone marrow stem cell administration.  ... reduction of therapeutic effect.  ...
(Date:10/9/2017)... Arizona (PRWEB) , ... October 09, 2017 , ... ... Kindred, a four-tiered line of medical marijuana products targeting the needs of consumers ... and packaging of Kindred takes place in Phoenix, Arizona. , As operators of ...
(Date:10/7/2017)... ... October 06, 2017 , ... ... launched its ProxiMeta™ Hi-C metagenome deconvolution product, featuring the first commercially available ... bioinformatics software to perform Hi-C metagenome deconvolution using their own facilities, supplementing ...
(Date:10/6/2017)... Washington, D.C. (PRWEB) , ... October 06, 2017 ... ... Cure) will host a lunch discussion and webinar on INSIGhT, the first-ever adaptive ... INSIGhT Principal Investigator, Dana-Farber Cancer Institute. The event is free and open to ...
Breaking Biology Technology:
Cached News: