HOME >> BIOLOGY >> NEWS
New Insight into cervical cancer development: turning it up a notch

A collaboration of scientists from Harvard Medical School and Brigham and Women's Hospital have uncovered a key genetic event in the progression of malignant cervical cancer -- and a potential new therapeutic target.

Dr. G. Paolo Dotto and colleagues have found that the decreased expression of a single gene, called Notch1, is instrumental in the late stages of human papilloma virus-induced cervical cancer. The report is published in the September 1 issue of Genes & Development.

Human papilloma virus (HPV) is the most prevalent sexually transmitted infection in the world, and HPV infection is associated with the majority of the 400,000 new cervical cancer cases reported annually. Previous genetic studies have, to some degree, elucidated the molecular mechanism of HPV-induced cervical carcinogenesis: The HPV genome encodes two viral proteins, E6 and E7, which interfere with two of the infected cell's primary tumor suppressor pathways (p53 and Rb). However, it is thought that while basal levels of E6/7 expression are necessary for HPV-induced cervical tumorigenesis, other genetic changes are needed to fully transform a normal cervical cell into a malignant one.

Dr. Dotto and colleagues have identified one such change.

Dr. Dotto and colleagues have discovered that the down-regulation of a cell signaling molecule, called Notch1, in HPV-infected cervical cells allows for the increased expression of E6 and E7, which, in turn, promote malignant cervical cell transformation. The researchers found that in low-grade HPV-positive cervical lesions, Notch1 is expressed at an adequate level to suppress E6 and E7, and thereby protects the cell against HPV-induced transformation. However, in high-grade HPV-positive cervical lesions, Notch1 expression is markedly decreased, relieving the suppression of E6 and E7 activity, and creating the correct genetic milieu for malignant cell transformation.

The researchers conclude that the reduced expre
'"/>

Contact: Heather Cosel
coselpie@cshl.org
Cold Spring Harbor Laboratory
31-Aug-2002


Page: 1 2

Related biology news :

1. Insight into transplant rejection might lead to novel prevention therapies
2. Insights on stroke from the peripheral blood suggest ways to develop markers and therapies
3. Insights gained from molecular modeling may lead to better insecticides
4. Nerac.com and Infinata partner to offer BioPharm Insight(TM) Resource
5. While the homeland is on alert, Technical Insights provides indispensable technology information
6. Insight into the genetic pathways that drive segmentation like clockwork
7. Reproductive Signals Affect Lifespan In Roundworm C. Elegans, Offering Possible Insight Into Human Aging Process
8. UCSF-Led Team Offers New Insight Into Neurological Basis Of Dyslexia
9. New Insights About Good Cholesterol
10. New Insights Into The Transport Machinery Of The Cell: A Single Protein Substitutes The Regulatory Machinery Specifying Endosome Fusion In Vitro
11. Search For Iron Transport Mechanism Leads To "Hephaestus," God Of Metal Working,Who Insight Into Iron-Deficiency Anemia

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/26/2020)... (PRWEB) , ... August 25, ... ... clinical-stage biotechnology company developing novel pharmaceuticals targeting mitochondria, in partnership with Essex ... enrolment in its pivotal U.S. Phase 3 VISTA-2 study of SkQ1 ophthalmic ...
(Date:8/23/2020)... (PRWEB) , ... August 21, 2020 , ... ... Rigaku Corporation has been published and is now available on the company’s ... X-ray diffraction—serves the X-ray analysis community, presenting current news and crystallographic research. ...
(Date:8/21/2020)... ... August 19, 2020 , ... ... conference and expo uniting life science, data science, informatics and IT leaders goes ... “In this period of uncertainty and change, Bio-IT takes the leadership role of ...
Breaking Biology News(10 mins):
(Date:8/3/2020)... ... ... Introducing Ardent Animal Health – MediVet Biologics rebrands company and positions its ... MediVet Biologics since its formation in 2016, the company is relaunching itself under the ... on its base of innovative therapies for osteoarthritis and cancer. , ...
(Date:7/31/2020)... (PRWEB) , ... July 29, 2020 , ... ... that can combine up to three different materials for use with CRM, neurostimulation, ... up to three materials to meet specific design requirements, performance, and cost criteria; ...
(Date:7/31/2020)... ... July 30, 2020 , ... ... life sciences industry, today announced the release of its signature product called ... Science Liaisons (MSLs) and other field medical professionals. , Beacon helps ...
(Date:7/18/2020)... DAYTON, Ohio (PRWEB) , ... July 16, 2020 ... ... clinical data solutions to aid in the early detection and prevention of high-burden ... partnership to enable US-based hospitals and healthcare organizations to utilize existing data in ...
Breaking Biology Technology:
Cached News: