New Insights About 'Good Cholesterol'

Enzyme Acts As Antioxidant

New research gives a clearer understanding of how so-called "good cholesterol" helps prevent heart disease and may one day lead to treatments, according to Canadian chemists. The scientists say they have determined that a particular enzyme bound to the "good" high-density lipoprotein, or HDL, acts as a powerful antioxidant within blood vessels.

The findings will appear in the American Chemical Society (ACS) peer-reviewed journal Biochemistry. ACS Web publication of the paper will be on April 27 and the research will be in the journal's May 11 print edition. ACS is the world's largest scientific society.

For years, epidemiological studies have shown higher blood levels of HDL reduce coronary artery disease. Recent studies show HDL may help ward off heart disease by preventing oxidative modifications of low-density lipoprotein (LDL) that lead to the formation of artery- clogging plaques. University of Ottawa Heart Institute biochemist Daniel L. Sparks, Ph.D., now says HDL's antioxidant ability is partly due to an attached enzyme called lecithin-cholesterol acyltransferase (LCAT).

"We have shown that LCAT has the ability to both eliminate and prevent the formation of oxidized lipids in plasma lipoproteins," claims Sparks. LCAT's role was previously thought to be limited to promoting cholesterol transport and clearance. While the mechanism for LCAT's antioxidant actions is still under investigation, Sparks maintains "the antioxidant activity is not short-lived as with vitamins C or E, since LCAT appears able to regenerate itself and efficiently maintain its ability to prevent oxidation."

Oxidative damage is thought to be involved in many diseases, including the biggest killers -- heart disease and cancer. Sparks thinks it may be possible to develop ways to enhance the antioxidant activity of LCAT in the body, and says his research has begun focusing on such efforts.


Contact: Charmayne Marsh
American Chemical Society

Page: 1

Related biology news :

1. Insights on stroke from the peripheral blood suggest ways to develop markers and therapies
2. Insights gained from molecular modeling may lead to better insecticides
3. While the homeland is on alert, Technical Insights provides indispensable technology information
4. New Insights Into The Transport Machinery Of The Cell: A Single Protein Substitutes The Regulatory Machinery Specifying Endosome Fusion In Vitro
5. UNC-CH Groucho Research Offers Insights Into How Embryo, Cancer Cells Communicate
6. New Insights On Sequence of Cell Death After Brain Injury: Understanding Cellular Events After Brain Trauma Could Lead To Better Therapies
7. Gene Discovery Provides Insights Into Epilepsy
8. Fauci To Present New Insights Into HIV Latency At 12th World AIDS Conference
9. Very Fruitful Collaboration Between French And German Scientists Yields Unusual Insights Into The Structure Of Membrane Proteins
10. New Insights Into The Enigma Of Lengthening Longevity
11. Insights Into The Proteasome - A Fascinating Macromolecular Machine For Protein Degradation

Post Your Comments:

(Date:4/4/2019)... ... April 02, 2019 , ... Orbsen Therapeutics, a biotechnology ... announced it will move its base of operations from the National University of ... created biotechnology park in Galway, Ireland. , “With four clinical trials in full ...
(Date:4/4/2019)... ... April 03, 2019 , ... R3 ... performed at its nationwide Centers of Excellence. R3 wants patients to feel secure ... , To protect patients from Centers that use inferior regenerative biologics, protocols or ...
(Date:3/29/2019)... (PRWEB) , ... March 28, 2019 , ... In the ... not directly prescribe a path for this task. Despite this uncertainty, several manufacturers have ... of today. In the first part of this webinar, learn how analytical similarity is ...
Breaking Biology News(10 mins):
(Date:4/8/2019)... ... April 08, 2019 , ... CallTower, ... announced today the launch of their app integration solution, CT Cloud Unite. ... contact-orientated applications while using CT Cloud Voice and Skype for Business solutions. This ...
(Date:3/29/2019)... ... March 28, 2019 , ... Specific ... CARB-X has proceeded with a second stage of funding for Specific’s Reveal™ rapid ... is on top of the $1.7 million already awarded by CARB-X. The additional ...
(Date:3/23/2019)... ... March 22, 2019 , ... Tosoh ... Light Scattering (MALS) detector , offering a revolutionary approach for the measurement of ... and biopolymers. A novel optical design, a unique cell-block assembly, and a new ...
(Date:3/19/2019)... ... ... free webinar will review strategies for data management in modular and adaptive clinical ... times by up to 30 percent, reducing cost while increasing quality, achieving clinical site set-up ... to migrate data – reducing risk and impact on trial success, trial teams, and trial ...
Breaking Biology Technology:
Cached News: