New Insights Into The Transport Machinery Of The Cell: A Single Protein,,Substitutes The Regulatory Machinery Specifying Endosome Fusion In Vitro

Endosomes are a good system to study how cells organise their internal transport logistics. Cells constantly internalise material from the external of the cell and distribute it to the other cellular compartments via specific organelles called endosomes. To bridge the distance between the cell surface and the endosomes, small membrane engulfed vesicles bud from the cell surface like soap bubbles and surround the cargo. Inside the cells there are thousands of such shuttle vesicles that have an important task: to specifically find their target organelle, dock with it and deliver their cargo by fusing with the target membrane. These organelles are surrounded by cytosol, the aqueous solution making up the inside of the cell and through which the vesicles navigate. The complexity comes from the fact that cytosol contains thousands of molecules and for a long time only a few have been recognised to regulate the specificity of the docking and fusing process. Researchers from the Max Planck Institute of Molecular Cell Biology and Genetics in Dresden/Germany, the European Molecular Biology Laboratory (EMBL) and collaborators from the University of Liverpool now successfully used purification and in vitro experiments to analyse the cytosolic proteins essential for this complex biological mechanism. They reported the new findings in this week's issue of "Nature" (Nature, Vol. 397, 18 February 1999).

In a first step it was necessary to separate proteins, which are involved in the regulation of endosome fusion from those, which are not. Starting point of this strategy was a family of proteins called Rabs, which are established key players in the activation of vesicle docking and fusion. Rabs act as molecular switches alternating between two stages: when active, they allow vesicle membranes to dock and fuse their targets, in their inactive state, fusion doesn't occur. "Rab5" is known to be a key player responsible for fusion of vesicles coming from the cell surface with

Contact: Marino Zerial

Page: 1 2 3

Related biology news :

1. Insights on stroke from the peripheral blood suggest ways to develop markers and therapies
2. Insights gained from molecular modeling may lead to better insecticides
3. While the homeland is on alert, Technical Insights provides indispensable technology information
4. New Insights About Good Cholesterol
5. UNC-CH Groucho Research Offers Insights Into How Embryo, Cancer Cells Communicate
6. New Insights On Sequence of Cell Death After Brain Injury: Understanding Cellular Events After Brain Trauma Could Lead To Better Therapies
7. Gene Discovery Provides Insights Into Epilepsy
8. Fauci To Present New Insights Into HIV Latency At 12th World AIDS Conference
9. Very Fruitful Collaboration Between French And German Scientists Yields Unusual Insights Into The Structure Of Membrane Proteins
10. New Insights Into The Enigma Of Lengthening Longevity
11. Insights Into The Proteasome - A Fascinating Macromolecular Machine For Protein Degradation

Post Your Comments:

(Date:6/11/2019)... ... June 12, 2019 , ... With ... Abveris plans to leverage the Geneious Biologics platform as a premium hub for ... Officer at Abveris, says: “The Geneious team has done an excellent job accommodating ...
(Date:6/6/2019)... ... June 05, 2019 , ... Ziegler, a ... advisor to Pathologists Bio-Medical Laboratories (PBM) on its recent acquisition by PathGroup. ... that provides services to more than one dozen hospitals and surgery centers in ...
(Date:6/4/2019)... ... , ... Most preclinical EEG visualization platforms offer tools intended ... on variations of amplitude, frequency or spike train detection. In the clinic, however, ... complexity and variability of the signal, and automation tools are used only in ...
Breaking Biology News(10 mins):
(Date:7/2/2019)... Calif. (PRWEB) , ... July 02, 2019 , ... Leading ... documentary entitled Animal Pharm: Where Beasts Meet Biotech. The film focuses on regenerative ... wild animals. Animal Pharm was recently included in the Brentwood and ...
(Date:6/18/2019)... (PRWEB) , ... June 18, 2019 , ... Personalized ... Investigational New Drug (IND) application to the FDA for use of a person’s own ... as a treatment of osteoarthritis in the knee. This IND is the first ...
(Date:6/11/2019)... ... 2019 , ... Advancements with Ted Danson will focus on ... 4Q/2019. Check your local listings for more information. , Advancements will explore Bio-ITech ... facilitates laboratories to improve efficiency and quality of research by providing comprehensive and ...
(Date:6/11/2019)... ... June 11, 2019 , ... Veterinary Regenerative ... Inc. (PSC) , has announced that their GMP facility for cell production is ... for manufacturing. This is an important milestone for VetStem as it expands ...
Breaking Biology Technology:
Cached News: