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New Insights Into The Transport Machinery Of The Cell: A Single Protein,,Substitutes The Regulatory Machinery Specifying Endosome Fusion In Vitro

the Rab5 regulated fusion machinery is a perfect model system to study the other Rab-dependent pathways in internal cell transport. After a more detailed characterisation of the molecular players of the transport route from the cell surface to the endosomes, the same system will be extended to investigate the transport leaving endosomes: the mechanism through which the internalised material is further distributed throughout the cell as well as the transport circuit which recycles membrane vesicles back to the plasma membrane. By this strategy it is hoped to identify and understand a central biological mechanism to an extent so far rarely known.


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Contact: Marino Zerial
zerial@embl-heidelberg.de
49-6221-387-232
Max-Planck-Gesellschaft
18-Feb-1999


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