HOME >> BIOLOGY >> NEWS
New MS research shows remarkable findings

Montreal, February 5, 2004 - New research findings from the Research Institute of the McGill University Health Center (MUHC) provide hope for patients with multiple sclerosis (MS), one of the most common and devastating diseases of the nervous system. These findings, published in today in Neuron, characterize an enzyme that plays a central role in the onset and progress of MS.

" We have identified a key enzyme that triggers MS-like disease in an animal model," says MUHC neuroscientist and Professor of Medicine at McGill University, Dr. Sam David. "We also show that blocking this enzyme has a remarkable effect in preventing disease and relapses."

MS, an autoimmune disease of the nervous system, affects approximately 35,000 young adults in Canada. It is twice as prevalent in females. MS is an inflammatory disease in which the body's own immune system attacks the insulating membranes surrounding nerve fibers. This damage results in loss of sensations and paralysis. Although genetic, infectious or environmental factors are thought to induce MS, the exact cause of the disease is still not known.

Dr. David with his Ph.D. student Athena Kalyvas showed in a mouse model of MS that the amount of the enzyme, phospholipase A2 (cPLA2), is increased in spinal cord lesions. They further demonstrated that treatment with a chemical inhibitor of this enzyme results in a marked reduction in the onset and severity of the disease.

"This discovery suggests that the cPLA2 enzyme may be an excellent target for the development of drugs to treat MS, " concluded Dr. David.


'"/>

Contact: Christine Zeindler
christine.zeindler@muhc.mcgill.ca
514-934-1934
McGill University
5-Feb-2004


Page: 1

Related biology news :

1. Leader in cancer treatment and prevention research honored
2. UT Southwestern receives $1.78 million grant for obesity research as part of NIH Roadmap initiative
3. Scientists to prototype cyberinfrastructure for research and education access to ocean observatories
4. Belgian researchers explore revolutionary approach to angiogenesis
5. Award winning researchers reveal potential new role for Glivec
6. New research shows plants can shuffle and paste gene pieces to generate genetic diversity
7. 16 APS exercise research highlights, from reduced flu mortality to proteomics & obesity
8. Gene chips research in cotton could lead to superior variety
9. Groundbreaking research could ignite new solutions to heat transfer in nano-devices
10. New hydrothermal vents discovered as South Pacific Odyssey research begins
11. University of Alberta researcher looks for clues to mysterious disease

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/30/2017)... , March 30, 2017  On April 6-7, ... Hack the Genome hackathon at Microsoft,s headquarters ... two-day competition will focus on developing health and wellness ... Hack the Genome is the first ... tremendous. The world,s largest companies in the genomics, tech ...
(Date:3/30/2017)... 2017 Trends, opportunities and forecast in this ... technology (fingerprint, AFIS, iris recognition, facial recognition, hand geometry, ... end use industry (government and law enforcement, commercial and ... and others), and by region ( North America ... Asia Pacific , and the Rest of the ...
(Date:3/28/2017)... PUNE, India , March 28, 2017 ... (Analog, IP, Biometrics), Hardware (Camera, Monitors, Servers, Storage Devices), ... Maintenance), Vertical, and Region - Global Forecast to 2022", ... 30.37 Billion in 2016 and is projected to reach ... 15.4% between 2017 and 2022. The base year considered ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... ... October 11, 2017 , ... At its ... announced Dr. Suneel I. Sheikh, the co-founder, CEO and chief research scientist of ... been selected for membership in ARCS Alumni Hall of Fame . ASTER ...
(Date:10/11/2017)... ... October 11, 2017 , ... Proscia ... be hosting a Webinar titled, “Pathology is going digital. Is your lab ready?” ... pathology adoption best practices and how Proscia improves lab economics and realizes an ...
(Date:10/11/2017)... ... October 11, 2017 , ... ... implantation and pregnancy rates in frozen and fresh in vitro fertilization (IVF) ... and maternal age to IVF success. , After comparing the results from the ...
(Date:10/10/2017)... (PRWEB) , ... October 10, 2017 , ... ... Science Center’s FirstHand program has won a US2020 STEM Mentoring Award. Representatives of ... award for Excellence in Volunteer Experience from US2020. , US2020’s mission is to ...
Breaking Biology Technology:
Cached News: