HOME >> BIOLOGY >> NEWS
New Model Makes It Possible To Predict Emergence Of Antiviral Drug Resistance

Researchers led by a UC San Francisco scientist have developed a model for predicting the emergence of antiviral drug resistance and for identifying the key factors that generate drug resistance.

The model, reported in the June 1 issue of Nature Medicine and lauded in an accompanying review by a Yale School of Management professor of management sciences and medicine, looked specifically at the likelihood of drug resistance occurring with increased use of a drug to treat genital herpes. The findings predicted that while increased use would lead to elevated levels of drug resistant strains, the number of cases of the disease would significantly decrease.

However, the greater significance of the study, said the principal investigator, Sally Blower, PhD, an associate professor of microbiology, immunology and medicine at UCSF, is the potential use of the new methodology for predicting drug resistance in many infectious diseases prone to antibiotic or antiviral resistance, including HIV.

"The methodology we've developed and applied to genital herpes can be used as a health policy tool to predict the likelihood of future levels of antibiotic or antiviral resistance for numerous infectious diseases, including HIV," said Blower.

A tool to predict future drug resistance is sorely needed, according to Edward H. Kaplan, PhD, of Yale in his review of the study. "This new model," he said, "provides a way to challenge the inertia often seen in public health decisions in which the overwhelming cost and timing required by empirical studies renders such analyses unfeasible, leading by default to decisions not to promote drug treatment when there is a risk of drug resistance developing."

The UCSF mathematical model, which traced the dynamics of drug-sensitive and drug-resistant herpes simplex virus in the general population, was designed to predict how much drug resistance could be expected to emerge over the next 50 years if treatment rates increased, and to iden
'"/>

Contact: Jennifer O'Brien
jobrien@itsa.ucsf.edu
(415) 476-2557
University of California - San Francisco
1-Jun-1998


Page: 1 2 3

Related biology news :

1. Applied Mathematical Models in Human Physiology
2. Model shows long-held constant in ocean nutrient ratio may vary as ecological conditions change
3. Models help estimate childrens exposure to toxins
4. Models show gene flow from crops threatens wild plants
5. U.S. - FSU Partnering Models
6. Model for common type of cancer developed by UCLA scientists
7. Modeling human lung cancer
8. The Chemical Leupeptin Protects Against Noise-Induced Hearing Loss In Animal Model, UB Hearing Researchers Show
9. Molecular Modeling Expands Chemistry Students Experiences
10. Model Polymers Reveal New Clues to Protein Folding
11. How Nerve Cells Get In Touch - A Molecular Model Of Synapse Formation And Retrograde Signalling In The Brain

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/22/2020)... (PRWEB) , ... July 21, 2020 , ... ... digital transformation and innovation in technology and compliance, announces a new solution to ... companies must ensure every layer of their technology stack complies with FDA and ...
(Date:7/10/2020)... ... July 09, 2020 , ... Today CJ BIO announced the ... share insight on the “fifth taste” phenomenon that is revolutionizing ingredient mixes, nutritional content ... will be live on Monday, July 13, 2020 at11:00 AM (CDT) during SHIFT20, the ...
(Date:7/1/2020)... ... July 01, 2020 , ... Catalent, a global leader in ... Pharmaceuticals’ packaging facility in Minakuchi, located in the Shiga prefecture of Japan. , ... Kakegawa, the new 60,000-square-foot facility will provide customers with flexible clinical supply solutions, ...
Breaking Biology News(10 mins):
(Date:7/31/2020)... ... 29, 2020 , ... G-CON Manufacturing, the leader in off-site ... FOR LIFE.” The adoption of this taglines comes at a time of tremendous ... to provide patients with urgently needed vaccines and other lifesaving pharmaceutical treatments. G-CON’s ...
(Date:7/31/2020)... ... July 29, 2020 , ... eSource has long been ... webinar will cover the history of eSource, the reasons it did not take off ... wearables, to site source, the industry is moving towards capturing data electronically for clinical ...
(Date:7/18/2020)... ... July 16, 2020 , ... After research model surgery and catheter implantation, ... surgery is only the beginning of a successful study, while protecting and accessing the ... Gien, Global Head of Surgery from Envigo in a live webinar ...
(Date:7/10/2020)... ... July 08, 2020 , ... ... announces a significant expansion of laboratory operations through its COVID-19 testing service, ... testing programs. , Bode-CARES provides a turnkey solution that includes ...
Breaking Biology Technology:
Cached News: