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New RNA libraries can selectively inactivate human genes

., in Huntsville, AL.

"For the first time this gives us the opportunity to do a version of forward genetics in mammalian cells -- where we can look at hypomorphic mutations, ranging from mild to severe, and their consequences on phenotypes, on what will eventually evolve to a genome-wide scale," said Hannon. "Thus, these libraries will evolve into an important resource for the research community."


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Contact: Jim Keeley
keeleyj@hhmi.org
301-215-8858
Howard Hughes Medical Institute
24-Mar-2004


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