HOME >> BIOLOGY >> NEWS
New Software Provides Quick Analysis of ion-Channel Activity

where ion channels are implicated.

For example, in people who have some kinds of inherited neuromuscular diseases, an amino acid in the receptors for the neurotransmitter has been altered, he said.

These alterations cause the ion channels either to stay open too long or not long enough, resulting in clinical disorders where the muscles are either too weak or too excitable.

By analyzing the currents that are produced by the ion channels that bind the transmitter, scientists have been able to tell which part of the channel operation is affected and suggest possible treatments.

QUB also is expected to be a boon to researchers who want to study protein dynamics in general. Since the flow of current through a channel makes many of the conformational states of ion channels visible, it is possible to see kinetic details that in most proteins are invisible.

An ion channel can pass more than 1 million ions per second,' Sachs said. That's a big enough output to measure in real time. The programs allow you to not only "watch" an ion channel molecule at work, they provide specific quantitative results on how it works, on how fast protein molecules change shape.

That information will give scientists a critical window into a protein's four-dimensional structure (in space and time), which determines its function, he explained.

The software uses algorithms based on the work of Russian mathematician Andrey Andreyevich Markov, similar to those currently used by computers to convert speech and handwriting to text.

It analyzes data obtained from experiments in which the electrical current produced by the ion channel in a cell is monitored and amplified.

That information is then fed to the computer.

The program then allows the researcher to develop accurate models of ion-channel behavior based on the experimental data.

The program says, "Give me a dataset and the models that you think apply, said Sachs. It then calculates which of the models pr
'"/>

Contact: Sue Wuetcher
wuetcher@newsb.buffalo.edu
716-645-2626
University at Buffalo
10-Oct-1996


Page: 1 2 3

Related biology news :

1. 5AM Solutions releases Microarray Enterprise Manage(TM) Software
2. Software tackles protein pathways
3. Software to make testing of new generic drugs more thorough
4. Software Helps Decipher Genomes Of Higher Organisms
5. Yeast Provides Evidence For Continuous Membrane Theory
6. Study Provides Guidance For Treating Patients With Brain Aneurysms
7. Discovery Of New Fossils In Gobi Desert Of Mongolia Provides Important Insight Into Early Mammal Evolution
8. Supplementing Diet With Fruits And Vegetables, Rather Than Vitamins, Provides Needed "Antioxidants"
9. Rare Brain Mapping Procedure Provides Unique Picture Of Two Areas Concerned With Language Processing and Production
10. Study Gone With The Wind Provides Stellar Ecological Example
11. Stargazer Gene Provides New Clues To Calcium Channel Defects In Absence Epilepsy

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: New Software Provides Quick Analysis ion Channel Activity

(Date:4/22/2014)... to Asia to coordinate with allies and reconfirm ... the Office of Naval Research (ONR) emphasized today ... an example of strong and growing ties between ... region. , The APTEP program, centered in Hawaii ... development of alternative energy technologies. It takes a ...
(Date:4/22/2014)... French . ... the complete genome and subsequent phylogenetic analysis show that ... that is distinct from strains previously identified in the ... also linked the laboratory confirmed cases with the initial ... virus is a lethal, highly contagious virus for which ...
(Date:4/22/2014)... that exposure to environmental enrichment can induce ... learning and memory. Previous studies have demonstrated ... the superficial layer of the cerebral cortex ... and these neurons exhibit very weak properties ... Whether environmental enrichment has an impact on ...
Breaking Biology News(10 mins):Full power: Alternative energy partnerships flourish in Asia 2Full power: Alternative energy partnerships flourish in Asia 3Inserm and the Institut Pasteur identify a new variant of Ebola virus in Guinea 2
(Date:1/14/2014)... Jan. 14, 2014 As pet owners drew up their lists ... them wrote: "Take better care of my furry companion." Nowadays there ... and top-brand carrying cases to take the little canine or feline ... feel compelled to buy some pricey toys at the pet store. ...
(Date:1/14/2014)... and BETHESDA, Md. , Jan. 14, ... with two institutes from the National Institutes of Health ... bringing safer, more effective treatments to patients on a ... for Advancing Translational Sciences (NCATS) and the National Eye ...
(Date:1/14/2014)... 2014  RXi Pharmaceuticals Corporation (OTCQX: RXII), a biotechnology ... therapies addressing major unmet medical needs using RNA-targeted ... of Allowance from the United States Patent and ... (sd-rxRNA®), for the treatment of fibrosis. The patent ...
(Date:1/14/2014)... USA, and Cardiff, UK (PRWEB) January 13, 2014 ... technology development leader with more than 20 years in ... for optics and photonics . Hainsey will serve as ... delighted to have Dr. Hainsey join SPIE as our ...
Breaking Biology Technology:New Year's Resolution: Give Pets the Gift of Top-Notch Health Care 2Organovo Announces Collaboration with National Institutes of Health 2Organovo Announces Collaboration with National Institutes of Health 3RXi Pharmaceuticals Receives US Notice of Allowance for a Key Patent Relating to its Self-Delivering Technology with sd-rxRNAs targeting CTGF, including RXI-109, for the Treatment of Fibrotic Disorders 2RXi Pharmaceuticals Receives US Notice of Allowance for a Key Patent Relating to its Self-Delivering Technology with sd-rxRNAs targeting CTGF, including RXI-109, for the Treatment of Fibrotic Disorders 3Photonics R&D Leader Bob Hainsey Joins SPIE Technical Staff 2
Cached News: