HOME >> BIOLOGY >> NEWS
New Software Provides Quick Analysis of ion-Channel Activity

where ion channels are implicated.

For example, in people who have some kinds of inherited neuromuscular diseases, an amino acid in the receptors for the neurotransmitter has been altered, he said.

These alterations cause the ion channels either to stay open too long or not long enough, resulting in clinical disorders where the muscles are either too weak or too excitable.

By analyzing the currents that are produced by the ion channels that bind the transmitter, scientists have been able to tell which part of the channel operation is affected and suggest possible treatments.

QUB also is expected to be a boon to researchers who want to study protein dynamics in general. Since the flow of current through a channel makes many of the conformational states of ion channels visible, it is possible to see kinetic details that in most proteins are invisible.

An ion channel can pass more than 1 million ions per second,' Sachs said. That's a big enough output to measure in real time. The programs allow you to not only "watch" an ion channel molecule at work, they provide specific quantitative results on how it works, on how fast protein molecules change shape.

That information will give scientists a critical window into a protein's four-dimensional structure (in space and time), which determines its function, he explained.

The software uses algorithms based on the work of Russian mathematician Andrey Andreyevich Markov, similar to those currently used by computers to convert speech and handwriting to text.

It analyzes data obtained from experiments in which the electrical current produced by the ion channel in a cell is monitored and amplified.

That information is then fed to the computer.

The program then allows the researcher to develop accurate models of ion-channel behavior based on the experimental data.

The program says, "Give me a dataset and the models that you think apply, said Sachs. It then calculates which of the models pr
'"/>

Contact: Sue Wuetcher
wuetcher@newsb.buffalo.edu
716-645-2626
University at Buffalo
10-Oct-1996


Page: 1 2 3

Related biology news :

1. 5AM Solutions releases Microarray Enterprise Manage(TM) Software
2. Software tackles protein pathways
3. Software to make testing of new generic drugs more thorough
4. Software Helps Decipher Genomes Of Higher Organisms
5. Yeast Provides Evidence For Continuous Membrane Theory
6. Study Provides Guidance For Treating Patients With Brain Aneurysms
7. Discovery Of New Fossils In Gobi Desert Of Mongolia Provides Important Insight Into Early Mammal Evolution
8. Supplementing Diet With Fruits And Vegetables, Rather Than Vitamins, Provides Needed "Antioxidants"
9. Rare Brain Mapping Procedure Provides Unique Picture Of Two Areas Concerned With Language Processing and Production
10. Study Gone With The Wind Provides Stellar Ecological Example
11. Stargazer Gene Provides New Clues To Calcium Channel Defects In Absence Epilepsy

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/20/2016)... , May 20, 2016  VoiceIt is excited ... with VoicePass. By working together, VoiceIt ...  Because VoiceIt and VoicePass take slightly different approaches ... increases both security and usability. ... about this new partnership. "This marketing ...
(Date:4/28/2016)... and BANGALORE, India , April 28, 2016 ... a product subsidiary of Infosys (NYSE: INFY ), ... a global partnership that will provide end customers ... mobile banking and payment services.      (Logo: ... innovation area for financial services, but it also plays a ...
(Date:4/15/2016)...  A new partnership announced today will help ... in a fraction of the time it takes ... life insurance policies to consumers without requiring inconvenient ... Diagnostics, rapid testing (A1C, Cotinine and HIV) and ... weight, pulse, BMI, and activity data) available at ...
Breaking Biology News(10 mins):
(Date:5/20/2016)... ... May 20, 2016 , ... The leading Regenerative Veterinary ... most experienced veterinary clients have treated over 100 of their own patients with the ... provide the highest level of care for their patients. , The veterinarians are ...
(Date:5/19/2016)... ... May 19, 2016 , ... Anton Paar USA, located in Ashland, Virginia is ... complete. The new structure adds a third office building to the current facilities. ... 2.4 acres of land, along with office space adjacent to the previous main building. ...
(Date:5/19/2016)... 2016 Regen BioPharma, ... RGBPP) announced today initiation of a preclinical development ... based cancer immunotherapeutic product leveraging its NR2F6 immunological ... a generation of cord blood derived killer cells ...  The product in development will be a "universal ...
(Date:5/18/2016)... 18, 2016 The Biotech industry continues ... mean that there are no opportunities ahead. Today, ActiveWallSt.com has ... THLD ), Seattle Genetics Inc. (NASDAQ: ... Ophthotech Corp. (NASDAQ: OPHT ). Sign up now ... http://www.activewallst.com/ Threshold Pharmaceuticals Inc.,s shares ...
Breaking Biology Technology:
Cached News: