HOME >> BIOLOGY >> NEWS
New Software Provides Quick Analysis of ion-Channel Activity

where ion channels are implicated.

For example, in people who have some kinds of inherited neuromuscular diseases, an amino acid in the receptors for the neurotransmitter has been altered, he said.

These alterations cause the ion channels either to stay open too long or not long enough, resulting in clinical disorders where the muscles are either too weak or too excitable.

By analyzing the currents that are produced by the ion channels that bind the transmitter, scientists have been able to tell which part of the channel operation is affected and suggest possible treatments.

QUB also is expected to be a boon to researchers who want to study protein dynamics in general. Since the flow of current through a channel makes many of the conformational states of ion channels visible, it is possible to see kinetic details that in most proteins are invisible.

An ion channel can pass more than 1 million ions per second,' Sachs said. That's a big enough output to measure in real time. The programs allow you to not only "watch" an ion channel molecule at work, they provide specific quantitative results on how it works, on how fast protein molecules change shape.

That information will give scientists a critical window into a protein's four-dimensional structure (in space and time), which determines its function, he explained.

The software uses algorithms based on the work of Russian mathematician Andrey Andreyevich Markov, similar to those currently used by computers to convert speech and handwriting to text.

It analyzes data obtained from experiments in which the electrical current produced by the ion channel in a cell is monitored and amplified.

That information is then fed to the computer.

The program then allows the researcher to develop accurate models of ion-channel behavior based on the experimental data.

The program says, "Give me a dataset and the models that you think apply, said Sachs. It then calculates which of the models pr
'"/>

Contact: Sue Wuetcher
wuetcher@newsb.buffalo.edu
716-645-2626
University at Buffalo
10-Oct-1996


Page: 1 2 3

Related biology news :

1. 5AM Solutions releases Microarray Enterprise Manage(TM) Software
2. Software tackles protein pathways
3. Software to make testing of new generic drugs more thorough
4. Software Helps Decipher Genomes Of Higher Organisms
5. Yeast Provides Evidence For Continuous Membrane Theory
6. Study Provides Guidance For Treating Patients With Brain Aneurysms
7. Discovery Of New Fossils In Gobi Desert Of Mongolia Provides Important Insight Into Early Mammal Evolution
8. Supplementing Diet With Fruits And Vegetables, Rather Than Vitamins, Provides Needed "Antioxidants"
9. Rare Brain Mapping Procedure Provides Unique Picture Of Two Areas Concerned With Language Processing and Production
10. Study Gone With The Wind Provides Stellar Ecological Example
11. Stargazer Gene Provides New Clues To Calcium Channel Defects In Absence Epilepsy

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/26/2016)... , April 27, 2016 ... the  "Global Multi-modal Biometrics Market 2016-2020"  report to ... ) , The analysts forecast the ... CAGR of 15.49% during the period 2016-2020.  ... number of sectors such as the healthcare, BFSI, ...
(Date:4/15/2016)... , April 15, 2016  A new partnership ... more accurate underwriting decisions in a fraction of ... competitively priced and high-value life insurance policies to ... With Force Diagnostics, rapid testing (A1C, ... data readings (blood pressure, weight, pulse, BMI, and ...
(Date:4/14/2016)... 14, 2016 BioCatch ™, ... today announced the appointment of Eyal Goldwerger ... Goldwerger,s leadership appointment comes at a time ... the deployment of its platform at several of the ... which discerns unique cognitive and physiological factors, is a ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... ... June 23, 2016 , ... In a new case report ... detail how a patient who developed lymphedema after being treated for breast cancer benefitted ... change the paradigm for dealing with this debilitating, frequent side effect of cancer treatment. ...
(Date:6/23/2016)... , June 23, 2016 ... Hematology Review, 2016;12(1):22-8 http://doi.org/10.17925/OHR.2016.12.01.22 ... , the peer-reviewed journal from touchONCOLOGY, Andrew ... escalating cost of cancer care is placing an ... result of expensive biologic therapies. With the patents ...
(Date:6/23/2016)... , ... June 23, 2016 , ... ... quality, regulatory and technical consulting, provides a free webinar on Performing ... July 13, 2016 at 12pm CT at no charge. , Incomplete investigations are ...
(Date:6/23/2016)... ReportsnReports.com adds 2016 global ... pharmaceuticals section with historic and forecast data along ... Complete report on the Cell Culture ... companies and supported with 261 tables and figures ... The Global Cell Culture Media Industry ...
Breaking Biology Technology:
Cached News: