HOME >> BIOLOGY >> NEWS
New Software Provides Quick Analysis of ion-Channel Activity

where ion channels are implicated.

For example, in people who have some kinds of inherited neuromuscular diseases, an amino acid in the receptors for the neurotransmitter has been altered, he said.

These alterations cause the ion channels either to stay open too long or not long enough, resulting in clinical disorders where the muscles are either too weak or too excitable.

By analyzing the currents that are produced by the ion channels that bind the transmitter, scientists have been able to tell which part of the channel operation is affected and suggest possible treatments.

QUB also is expected to be a boon to researchers who want to study protein dynamics in general. Since the flow of current through a channel makes many of the conformational states of ion channels visible, it is possible to see kinetic details that in most proteins are invisible.

An ion channel can pass more than 1 million ions per second,' Sachs said. That's a big enough output to measure in real time. The programs allow you to not only "watch" an ion channel molecule at work, they provide specific quantitative results on how it works, on how fast protein molecules change shape.

That information will give scientists a critical window into a protein's four-dimensional structure (in space and time), which determines its function, he explained.

The software uses algorithms based on the work of Russian mathematician Andrey Andreyevich Markov, similar to those currently used by computers to convert speech and handwriting to text.

It analyzes data obtained from experiments in which the electrical current produced by the ion channel in a cell is monitored and amplified.

That information is then fed to the computer.

The program then allows the researcher to develop accurate models of ion-channel behavior based on the experimental data.

The program says, "Give me a dataset and the models that you think apply, said Sachs. It then calculates which of the models pr
'"/>

Contact: Sue Wuetcher
wuetcher@newsb.buffalo.edu
716-645-2626
University at Buffalo
10-Oct-1996


Page: 1 2 3

Related biology news :

1. 5AM Solutions releases Microarray Enterprise Manage(TM) Software
2. Software tackles protein pathways
3. Software to make testing of new generic drugs more thorough
4. Software Helps Decipher Genomes Of Higher Organisms
5. Yeast Provides Evidence For Continuous Membrane Theory
6. Study Provides Guidance For Treating Patients With Brain Aneurysms
7. Discovery Of New Fossils In Gobi Desert Of Mongolia Provides Important Insight Into Early Mammal Evolution
8. Supplementing Diet With Fruits And Vegetables, Rather Than Vitamins, Provides Needed "Antioxidants"
9. Rare Brain Mapping Procedure Provides Unique Picture Of Two Areas Concerned With Language Processing and Production
10. Study Gone With The Wind Provides Stellar Ecological Example
11. Stargazer Gene Provides New Clues To Calcium Channel Defects In Absence Epilepsy

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: New Software Provides Quick Analysis ion Channel Activity

(Date:7/27/2015)... 2015  Synaptics Inc. (NASDAQ: SYNA ), ... announced that Huawei has selected the Synaptics ® ... stylish smartwatch. Huawei chose the state-of-the-art ClearPad capacitive ... and highly responsive human interface qualities such as ... required a classic round watch face and Synaptics ...
(Date:7/27/2015)... July 27, 2015   Zynx Health ™, ... clinical improvement solutions, today announced that its ... available on Android smartphones and tablets. With this ... organizations can use ZynxCarebook to securely exchange messages ... streamline care transitions to other care settings, and ...
(Date:7/23/2015)... -- Aware, Inc. (NASDAQ: AWRE ), a leading supplier ... its second quarter ended June 30, 2015.  ... a decrease of 33% compared to $6.8 million in the ... of 2015 was $0.3 million, or $0.01 per diluted share, ... in the same period a year ago.  ...
Breaking Biology News(10 mins):Synaptics Touchscreen Solution Powers New Huawei Watch 2Synaptics Touchscreen Solution Powers New Huawei Watch 3Zynx Health Adds Android Device Support to ZynxCarebook Solution 2Zynx Health Adds Android Device Support to ZynxCarebook Solution 3Aware, Inc. Reports Second Quarter 2015 Financial Results 2Aware, Inc. Reports Second Quarter 2015 Financial Results 3Aware, Inc. Reports Second Quarter 2015 Financial Results 4Aware, Inc. Reports Second Quarter 2015 Financial Results 5Aware, Inc. Reports Second Quarter 2015 Financial Results 6
(Date:7/27/2015)... YORK , July 27, 2015 ... today announced the winners of its annual Klerman ... research by scientists who have been supported by ... career scientists to pursue innovative ideas in neurobiological ... "proof" of concept for the early detection, treatment, ...
(Date:7/26/2015)... (PRWEB) , ... July 26, 2015 , ... ... of its VALIDATE® ANEMIA calibration verification / linearity test kit. The VALIDATE® ANEMIA ... Each VALIDATE® ANEMIA kit is prepared using the CLSI recommended “equal delta” method ...
(Date:7/24/2015)... 2015 Equity Research Institute has ... (NASDAQ: PDLI ), Arena Pharmaceuticals Inc. (NASDAQ: ... Biotherapeutics Inc. (NASDAQ: NWBO ), and Acorda Therapeutics ... PDL BioPharma can be accessed at https://www.EquityResearchInstitute.com/reports?keyword=PDLI ... at 5,146.41, down 0.49%, the Dow Jones Industrial Average ...
(Date:7/24/2015)... 24, 2015 The global ... USD 27.8 billion by 2022, growing at an estimated ... a new study by Grand View Research, Inc. Development ... to result in significant reduction in cost of sequencing ... and usage rates of next generation sequencing throughout the ...
Breaking Biology Technology:Brain & Behavior Research Foundation Names Winners of Klerman-Freedman Prizes for Exceptional Research 2Brain & Behavior Research Foundation Names Winners of Klerman-Freedman Prizes for Exceptional Research 3Brain & Behavior Research Foundation Names Winners of Klerman-Freedman Prizes for Exceptional Research 4Brain & Behavior Research Foundation Names Winners of Klerman-Freedman Prizes for Exceptional Research 5Brain & Behavior Research Foundation Names Winners of Klerman-Freedman Prizes for Exceptional Research 6Maine Standards Company, LLC Announces Release of VALIDATE® ANEMIA Calibration Verification / Linearity Test Kit 2Biotechnology Stocks in Motion -- PDL BioPharma, Arena Pharma, StemCells, Northwest Biotherapeutics, and Acorda Therapeutics 2Biotechnology Stocks in Motion -- PDL BioPharma, Arena Pharma, StemCells, Northwest Biotherapeutics, and Acorda Therapeutics 3Biotechnology Stocks in Motion -- PDL BioPharma, Arena Pharma, StemCells, Northwest Biotherapeutics, and Acorda Therapeutics 4Biotechnology Stocks in Motion -- PDL BioPharma, Arena Pharma, StemCells, Northwest Biotherapeutics, and Acorda Therapeutics 5Next Generation Sequencing (NGS) Market To Reach $27.8 Billion By 2022: Grand View Research, Inc. 2Next Generation Sequencing (NGS) Market To Reach $27.8 Billion By 2022: Grand View Research, Inc. 3Next Generation Sequencing (NGS) Market To Reach $27.8 Billion By 2022: Grand View Research, Inc. 4Next Generation Sequencing (NGS) Market To Reach $27.8 Billion By 2022: Grand View Research, Inc. 5
Cached News: