HOME >> BIOLOGY >> NEWS
New Test Opens Window On Corrosive Free-Radical Activity In Individuals

Do antioxidant vitamins protect healthy people from free-radical damage, a process implicated in heart disease, stroke, and cancer, as well as such normal aspects of aging as wrinkled skin? Can some diseases be slowed or reversed with antioxidant compounds?

Perhaps surprisingly, researchers have yet to answer these seemingly straightforward questions, because no technique has existed to easily and directly measure the corrosive effects in the body of these highly reactive types of oxygen nor to assess the effectiveness of any countermeasures that might be taken.

Now, University of Pennsylvania Medical Center scientists have developed a new test to accurately and noninvasively measure free-radical activity in individuals. The method, detailed in the March 31 issue of the Proceedings of the National Academy of Sciences, is both simpler and more sensitive than one developed earlier by the same group. Taken together, the two assays corroborate each other and provide a powerful set of tools to address the role of free radicals in health and disease.

"Do healthy people derive any benefit from taking antioxidants if they have a strong native antioxidant defense?" asks Garret A. FitzGerald, MD, chairman of the department of pharmacology and senior author on the study. "Can antioxidants contribute significantly to the prevention or treatment of disease? This new test will allow us to answer these and other important questions about free-radical activity in individuals."

To date, the evidence linking free radicals to disease and aging -- through a biochemical process analogous to rusting -- and the supposition that antioxidants can limit the deleterious effects of free radicals have been based on statistical studies of groups of people and on test-tube experiments with cells in the laboratory.

These methods, although valuable, give no insight into variation between individuals, some of whom may possess highly
'"/>

Contact: Franklin Hoke
hokef@mail.med.upenn.edu
215-349-5659
University of Pennsylvania School of Medicine
31-Mar-1998


Page: 1 2 3

Related biology news :

1. Understanding Molecular Self-Assembly Opens Door For New Sources Of Wood-Like Materials
2. Programmable Cells Open Window Of Opportunity For Gene Therapy
3. X-Ray Concentrator Will Expand Window On High-Energy Universe
4. PEBBLEs Help U-M Scientists Open A Window On Cell Chemistry
5. Female Adolescents Need Calcium During Window Of Opportunity
6. New Materials Remove Corrosive Gas In Coal-Gasification Process
7. Activity of calcium-handling gene appears to prevent cardiac arrhythmias
8. Activity detailed for sirtuins, involved in metabolism, aging, gene expression
9. Activity decrease in exercising older adults linked to decline in resting metabolism
10. UT Southwestern Researchers Find Way To Control Gene Activity, Opening Way For Cancer Drugs
11. Research Findings Suggest Potent, Broad-Spectrum Antiviral Activity For Vertexs Investigational IMPDH Inhibitor VX-497

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/22/2016)... and SANDY, Utah , March ... operates the highest sample volume laboratory in ... and UNIConnect, leaders in clinical sequencing informatics and molecular ... of a project to establish the informatics infrastructure for ... NSO has been contracted by the Ontario Ministry ...
(Date:3/15/2016)... March 15, 2016 Yissum Research Development ... technology-transfer company of the Hebrew University, announced today the ... sensing technology of various human biological indicators. Neteera Technologies ... million from private investors. ... the detection of electromagnetic emissions from sweat ducts, enables ...
(Date:3/10/2016)... , March 10, 2016 ... market research report "Identity and Access Management Market by ... Compliance, and Governance), by Organization Size, by Deployment, by ... published by MarketsandMarkets, The market is estimated to grow ... Billion by 2020, at a Compound Annual Growth Rate ...
Breaking Biology News(10 mins):
(Date:5/27/2016)... (PRWEB) , ... May 27, 2016 , ... PBI-Gordon Corporation ... Turf and Ornamental Products. , In his 15-year career with PBI-Gordon, Dave has served ... Manager, where he was integral in the development and launch of many of PBI-Gordon’s ...
(Date:5/26/2016)... New Jersey and READING, ... Indegene ( http://www.indegene.com ), a leading ... to life science, pharmaceutical and healthcare organisations and ... of innovative scientific support throughout the product lifecycle, ... with the launch of IntraScience.      ...
(Date:5/26/2016)... ... May 26, 2016 , ... ... are used in leading laboratories all over the globe. Their cute firefly logo ... to manufacturing awesome cuvettes, FireflySci makes spectrophotometer calibration standards that never require recalibration. ...
(Date:5/25/2016)... (PRWEB) , ... May 25, 2016 , ... ... for information (RFI) issued by the Office of the National Coordinator for Health ... experience, and determines if clinically relevant data were available when and where it ...
Breaking Biology Technology:
Cached News: