HOME >> BIOLOGY >> NEWS
New Test Opens Window On Corrosive Free-Radical Activity In Individuals

Do antioxidant vitamins protect healthy people from free-radical damage, a process implicated in heart disease, stroke, and cancer, as well as such normal aspects of aging as wrinkled skin? Can some diseases be slowed or reversed with antioxidant compounds?

Perhaps surprisingly, researchers have yet to answer these seemingly straightforward questions, because no technique has existed to easily and directly measure the corrosive effects in the body of these highly reactive types of oxygen nor to assess the effectiveness of any countermeasures that might be taken.

Now, University of Pennsylvania Medical Center scientists have developed a new test to accurately and noninvasively measure free-radical activity in individuals. The method, detailed in the March 31 issue of the Proceedings of the National Academy of Sciences, is both simpler and more sensitive than one developed earlier by the same group. Taken together, the two assays corroborate each other and provide a powerful set of tools to address the role of free radicals in health and disease.

"Do healthy people derive any benefit from taking antioxidants if they have a strong native antioxidant defense?" asks Garret A. FitzGerald, MD, chairman of the department of pharmacology and senior author on the study. "Can antioxidants contribute significantly to the prevention or treatment of disease? This new test will allow us to answer these and other important questions about free-radical activity in individuals."

To date, the evidence linking free radicals to disease and aging -- through a biochemical process analogous to rusting -- and the supposition that antioxidants can limit the deleterious effects of free radicals have been based on statistical studies of groups of people and on test-tube experiments with cells in the laboratory.

These methods, although valuable, give no insight into variation between individuals, some of whom may possess highly
'"/>

Contact: Franklin Hoke
hokef@mail.med.upenn.edu
215-349-5659
University of Pennsylvania School of Medicine
31-Mar-1998


Page: 1 2 3

Related biology news :

1. Understanding Molecular Self-Assembly Opens Door For New Sources Of Wood-Like Materials
2. Programmable Cells Open Window Of Opportunity For Gene Therapy
3. X-Ray Concentrator Will Expand Window On High-Energy Universe
4. PEBBLEs Help U-M Scientists Open A Window On Cell Chemistry
5. Female Adolescents Need Calcium During Window Of Opportunity
6. New Materials Remove Corrosive Gas In Coal-Gasification Process
7. Activity of calcium-handling gene appears to prevent cardiac arrhythmias
8. Activity detailed for sirtuins, involved in metabolism, aging, gene expression
9. Activity decrease in exercising older adults linked to decline in resting metabolism
10. UT Southwestern Researchers Find Way To Control Gene Activity, Opening Way For Cancer Drugs
11. Research Findings Suggest Potent, Broad-Spectrum Antiviral Activity For Vertexs Investigational IMPDH Inhibitor VX-497

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: New Test Opens Window Corrosive Free Radical Activity Individuals

(Date:8/21/2014)... dandruff, eczema and other itchy, flaky maladies in humans ... Hawaiian coral reefs and the extreme environments of arctic ... the scientific journal PLOS Pathogens considers the ... genus Malassezia in light of new insights ... world. , University of Hawai,i at Mānoa scientist Anthony ...
(Date:8/21/2014)... improving the food intake, health and quality of life ... three projects at the University of Waterloo receiving close ... of Health Research (CIHR). , Professor Heather Keller, ... and a Schlegel research chair in nutrition and aging, ... many Canadians living in long-term care homes are poorly ...
(Date:8/21/2014)... a finding that has implications for life in other ... the solar system, LSU Associate Professor of Biological Sciences ... Science Foundation, or NSF, this week published a paper ... that lies 800 meters (2600 feet) beneath the surface ... ecosystems.", Given that more than 400 subglacial lakes and ...
Breaking Biology News(10 mins):From dandruff to deep sea vents, an ecologically hyper-diverse fungus 2Grants will fund landmark aging research at Waterloo 2800 meters beneath Antarctic ice sheet, subglacial lake holds viable microbial ecosystems 2800 meters beneath Antarctic ice sheet, subglacial lake holds viable microbial ecosystems 3800 meters beneath Antarctic ice sheet, subglacial lake holds viable microbial ecosystems 4
(Date:8/22/2014)... August 22, 2014 Nerium International, ... is in the spotlight again. Nerium will showcase ... its NeriumFirmTM Body Contouring Cream to Hollywood’s elite ... Creations during the 66th Primetime Emmy® Awards. , ... extract, third-party clinical trials show that NeriumAD night ...
(Date:8/21/2014)... 2014 DNA vaccine pioneer Immunomic ... development of JRC-LAMP-vax, an innovative and safe potential treatment ... studies began this month in Hawaii, moving the world ... The Japanese red cedar releases pollen that causes devastating ... Cedar pollen wreaks similar havoc in Colorado, New Mexico ...
(Date:8/21/2014)... , August 21, 2014 ... http://www.researchandmarkets.com/research/3zh3q8/global_hormone ) has announced the addition of ...  report to their offering.       ... as hormone therapy, is a means of ... produced by the body. This type of ...
(Date:8/21/2014)... , Aug. 21, 2014  Decision Resources Group ... Brazil and Mexico ... of several newly approved agents, the anticipated label ... and the launch of emerging biologics will substantially ... particular, the emerging IL-5 inhibitors will introduce a ...
Breaking Biology Technology:Nerium International Joins Television’s Biggest Stars at Backstage Creations Giving Suite at the 66th Primetime Emmy Awards 2Nerium International Joins Television’s Biggest Stars at Backstage Creations Giving Suite at the 66th Primetime Emmy Awards 3Relief for Allergy Sufferers Finally in Sight: Immunomic Therapeutics Closes in on Treatment for Hay Fever in Japan, U.S. 2Relief for Allergy Sufferers Finally in Sight: Immunomic Therapeutics Closes in on Treatment for Hay Fever in Japan, U.S. 3Relief for Allergy Sufferers Finally in Sight: Immunomic Therapeutics Closes in on Treatment for Hay Fever in Japan, U.S. 4Global Hormone Replacement Therapy Market 2014-2018: Key Vendors are Actavis, Bayer, Merck & Co, Novartis and Novo Nordisk 2Asthma Agents Currently Face a Suboptimal Coverage Environment in Brazil and Mexico, and as the Treatment Armamentarium Expands, Competitiveness Will Further Intensify 2Asthma Agents Currently Face a Suboptimal Coverage Environment in Brazil and Mexico, and as the Treatment Armamentarium Expands, Competitiveness Will Further Intensify 3
Cached News: