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New Tuberculosis Vaccine Candidate Developed: Improved Delivery Of Antigens By Current Vaccine BCG (Bacille Calmette-Gurin)

orming listeriolysin (Hly) of Listeria monocytogenes. Hly expression by r-BCG facilitates access of antigens to the cytosol of host cells which in turn represents a route for increased introduction of antigens into MHC class I presentation pathways. Their data suggest that Hly secretion endows r-BCG with an improved capacity to stimulate CD8 T cells. Because CD8 T cells play a major role in protection against M.tuberculosis infection such r-BCG strains are potential tuberculosis vaccines.


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Contact: Juergen Hess
hess@mpiib-berlin.mpg.de
+49-30-2802-6483
Max-Planck-Gesellschaft
28-Apr-1998


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