Enoxaparin Treatment Improves the Gestational Outcome of Pregnant Women with Thrombophilia and Recurrent Pregnancy Loss: The LIVE-ENOX Study (Abstract 43)
It is estimated that recurrent pregnancy loss affects two to five percent of all couples desiring pregnancy. Historically, the cause of recurrent pregnancy loss was unknown in most couples. Recent research has shown a possible link between maternal thrombophilia, a blood disorder in which there is an increased risk of thrombosis, and recurrent pregnancy loss. LIVE-ENOX is a multi-center, randomized trial that investigated the use of an anticoagulant therapy, enoxaparin, for improving pregnancy outcomes in patients with thrombophilia and recurrent pregnancy loss. Results showed that enoxaparin, administered in doses of either 40 mg/day or 80 mg/day, appears safe and comparably effective in the prevention of pregnancy loss for thrombophilic women with recurrent pregnancy loss. Data also demonstrated an apparent reduction in the incidence of preeclampsia and placental abruption, two complications of pregnancy that are known to negatively affect birth outcomes.
"Loss of pregnancy is a physically and emotionally challenging ordeal. When pregnancy loss is repetitive, these feelings are magnified," explains Benjamin Brenner, M.D., of the Rambam Medical Center, Haifa, Israel, lead investigator of the study. "Results from this study may give hope to the thousands of couples who are still in need of an effective treatment for thrombophilia-related recurrent pregnancy loss."
Women with thrombophilia and recurrent pregnancy loss were enrolled at five to 10 weeks of gestation and grouped according to the number of previous pregnancy losses and length of pregnancies before previous losses (three or more pregnancy losses in first trimester,
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American Society of Hematology
6-Dec-2003