New advances in thrombosis help further understanding of disease ...( two or more losses in second trimester...)

two or more losses in second trimester, or one or more losses in third trimester), and type of thrombophilia. Treatment with enoxaparin was given throughout the pregnancy and postpartum period. The primary efficacy endpoint was delivery of a live, healthy baby. The safety endpoints were bleeding episodes in newborns and mothers and thrombocytopenia in mothers, a blood condition leading to increased bleeding and decreased clotting ability. Treatment with enoxaparin significantly increased the rate of live births compared to patients' historical rates of live birth (81.4 percent versus 28.2 percent for 40 mg and 76.5 percent versus 28.3 percent for 80 mg). Treatment with enoxaparin was also shown to decrease the rate of preeclampsia and placental abruption. No instances of maternal or neonatal bleeding were observed. Enoxaparin is safe and effective for prevention of pregnancy loss in women with thrombophilia.

A Phase II Randomized, Double-Blind, Five-Arm, Parallel Group, Dose-Response Study to a New Oral Directly-Acting Factor Xa Inhibitor, Razaxaban, for the Prevention of Deep Vein Thrombosis in Knee Replacement Surgery on Behalf of the Razaxaban Investigators (Abstract 41)

Venous thromboembolism, a dangerous condition in which blood clots break away from the site of formation, become lodged in a blood vessel, and obstruct blood flow, is a common complication for major joint replacement surgeries. There is a need for new antithrombotic drugs that are safer and more effective than those currently available. Researchers from orthopedic clinics in the U.S., Canada, and Australia conducted a phase II randomized, double-blind, controlled, dose-response study to investigate razaxaban, a new oral, directly acting inhibitor of coagulation factor Xa. Results showed that razaxaban administered at 25 mg twice a day (bid) appears to reduce the risk of venous thromboembolism after major orthopedic surgery with similar safety compared to c
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Contact: Aimee Frank
amf@spectrumscience.com
202-955-6222
American Society of Hematology
6-Dec-2003

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