New analysis gives cancer patients personalized prognosis

DURHAM, N.C. -- Researchers at Duke University have developed a new analytical approach that combines genetic and clinical data to give cancer patients an individualized prognosis of their cancer recurrence. The information could prove critical in deciding how aggressively to treat the disease following surgery.

The researchers reported their findings using breast cancer as a test case in the April 26, 2004, online early edition of the Proceedings of the National Academy of Sciences.

"Currently, it is primarily traditional clinical information alone that aids in understanding a patient's risk profile," said Mike West, Ph.D., Arts & Sciences professor of statistics and decision sciences at Duke and lead author on the study. "However, the resulting predictions typically lump patients into broad categories. Access to detailed genomic information now provides the opportunity to move far beyond this -- toward customized risk predictions and prognoses more widely, for the individual patient."

Nevertheless, most previous studies that have focused on developing genomic-based predictors of cancer recurrence risk have only broadly defined patients as high versus low risk, leaving considerable room for error about an individual's true chance of recurrence, the researchers said. The power of the Duke team's approach to improve such predictions lies in the combined use of multiple sources of clinical and genomic data, they said.

In their case study of breast cancer, the Duke team developed methods that utilize diverse information including traditional clinical variables, such as lymph node and estrogen receptor status, and multiple, complex patterns of gene activity, or "genetic fingerprints," of a patient's tumor. They integrated these data to formulate unique predictions about individual patients' recurrence risk. While the Duke study focused on patients with breast cancer, the approach is applicable more broadly to any form of cancer and can in

Contact: Kendall Morgan
Duke University Medical Center

Page: 1 2 3 4

Related biology news :

1. Human chromosome 5 final sequence analysis released to public
2. Genetic analysis rewrites salamanders evolutionary history
3. Proven method of bone analysis may clarify human origins
4. Carnegie Mellon U. conducts first comprehensive proteomic analysis of developing animal
5. Online calculator improves analysis of chemical data
6. Scientists discover way to streamline analysis of maize genome
7. Automated analysis of bee behavior may yield better robots
8. High-tech analysis of vineyard soil
9. SARS virus can change quickly and unpredictably, analysis indicates
10. Human rights in Peru: AAAS analysis doubles previous estimates of killings
11. Global analysis finds a large portion of the earth is still wilderness

Post Your Comments:

(Date:7/10/2020)... ... ... Today CJ BIO announced the first in a series of Food Ingredient MasterClass webinars, ... revolutionizing ingredient mixes, nutritional content and flavor profiles across a range of savory foods ... AM (CDT) during SHIFT20, the virtual edition of the IFT Annual Meeting & Food ...
(Date:7/1/2020)... ... 2020 , ... Cure Glioblastoma, a registered 501(c)(3) nonprofit research ... adult brain cancer—announced today the appointments of its first Senior Fellows: John Boockvar, ... organization’s initiatives and overall vision. , "Senior Fellows are more than advisors; they ...
(Date:6/23/2020)... ... June 23, 2020 , ... First Aid Africa, ... a UK supplier and manufacturer of innovative portable renewable energy equipment, have announced ... fight against the COVID-19 pandemic in Zambia. , One of Renovagen’s FAST FOLD ...
Breaking Biology News(10 mins):
(Date:7/31/2020)... ... July 29, 2020 , ... R3 Stem Cell International is ... $3950. With 50 million stem cells total, patients may choose which extremities they would ... for arthritic joints (BMC Musculoskelet Disord. 2016). At R3 International, umbilical cord tissue is ...
(Date:7/31/2020)... , ... July 29, 2020 , ... ... Catalent, the leading global provider of advanced delivery technologies, development, and manufacturing solutions ... that they have entered into a strategic partnership whereby Catalent will provide support ...
(Date:7/22/2020)... ... 22, 2020 , ... Join experts from Reed Tech , Gary Saner, ... a one hour live webinar on Thursday, August 13, 2020 at 11am ... and medical devices. Specifically, for medical devices, the NMPA has departments dealing with medical ...
(Date:7/18/2020)... ... 17, 2020 , ... dicentra , a leading Contract ... industries, is pleased to announce that Charles Galea has joined its clinical trials ... is an accomplished and results-driven sales executive with over 10 years of expertise ...
Breaking Biology Technology:
Cached News: