HOME >> BIOLOGY >> NEWS
New approach limits damage after heart attack and improves survival, say Scripps Research scientists

A team led by scientists at The Scripps Research Institute has developed a potential new treatment for heart attacks. The therapy inhibits fluid leakage from cardiac blood vessels following a heart attack and thereby significantly prevents long-term heart damage and improves survival.

"Immediately following a heart attack, blood vessels near the site of injury become leaky, causing fluid accumulation in the healthy area of the heart surrounding the injured site," says Immunology Professor David A. Cheresh, Ph.D., who led the research with postdoctoral fellow Sara Weis, Ph.D at The Scripps Research Institute. This permeability response is devastating to normal heart tissue.

"Until now," continues Cheresh, "nobody has realized the extent to which this leak response damages heart tissue and causes long-term tissue injury. We discovered a way to block this process and thus save heart tissue from irreversible damage."

Using laboratory models that are designed to mimic the pathology of heart attacks in humans, Cheresh, Weis, and their colleagues found that a single dose of a compound designed to block this fluid leakage (which is called edema) can, even if given as late as six hours after the event, drastically reduce tissue injury and increase long-term survival following a heart attack.

A biopharmaceutical company, TargeGen Inc. in San Diego, is finalizing preclinical studies to translate these initial research findings into practical human therapies. Using extensive preclinical models that mirror human heart attacks, TargeGen scientists report that 40 to 60 percent reductions in infarct (tissue injury) size with a small molecule drug that inhibits vascular leak and edema. Based on the encouraging preclinical efficacy and safety studies, TargeGen plans to initiate a combined Phase I/II human clinical trial in the second half of 2004 for patients undergoing an acute heart attack.

In addition to Cheresh and Weis, the team
'"/>

Contact: Jason Bardi
jasonb@scripps.edu
858-784-9254
Scripps Research Institute
15-Mar-2004


Page: 1 2 3 4 5

Related biology news :

1. Belgian researchers explore revolutionary approach to angiogenesis
2. Novel IBD therapeutic approaches reported from Washington Univ., Barcelona, LSU at APS meeting
3. Researchers recommend new approach to combat drug-resistant staph infections
4. U. Iowa muscular dystrophy discovery may lead to new treatment approaches
5. New research suggests therapeutic approach for autoimmune diseases
6. New approach offers potential drug-discovery shortcut
7. Steroid-coated DNA represents new approach to gene delivery
8. Two-drug approach might shorten painful labor, reduce Caesarean sections
9. Death-defying approach devised by Penn scientists to prevent cell apoptosis
10. Smallpox in 50-year-old tissues detected by integrated diagnostics approach
11. One-size-fits-all approach to nutrition recommendations may soon be outdated

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:11/29/2018)... ... November 29, 2018 , ... ACEA Biosciences , now ... Engineering Research Center for Cell Manufacturing Technologies (CMaT). CMaT is a ... and technologies for the consistent, scalable and low-cost production of high-quality living therapeutic ...
(Date:11/27/2018)... ... November 26, 2018 , ... uBiome, the ... of the website IBDwatch and Gastroenterology Fellow at the University of Louisville, to ... around the world, Dr. Wuerth will bring to uBiome knowledge and research on ...
(Date:11/27/2018)... CARLSBAD, Calif. (PRWEB) , ... November 27, 2018 ... ... & Sons. The companies have worked together to integrate the LabArchives Classroom ... students. The combined offering will be available beginning January of 2019. ...
Breaking Biology News(10 mins):
(Date:12/5/2018)... ZOETERMEER, Netherlands (PRWEB) , ... December 05, 2018 , ... ... last week paid tribute to in the European Parliament by Carlos Moedas, the European ... High-Level Conference EU Research and Innovation in Our Daily Lives, Commissioner Moedas spoke at ...
(Date:11/28/2018)... ... 2018 , ... Earlier this month, Lajollacooks4u's Founder and Chef Jodi Abel traveled ... of truffle season. , Her first stop was Umbria, a region in ... Black Truffle Lodge in the small mountain village of Pettino, Chef Jodi was introduced ...
(Date:11/20/2018)... ... November 19, 2018 , ... Patients with missing teeth in Sandy ... from Dr. Dan Myers at THE DENTIST Centers without a referral. Dr. Myers ... for the last 20 years. He now offers skilled dental care in two practice ...
(Date:11/13/2018)... ... 13, 2018 , ... Renowned Honolulu veterinarian, Dr. Patrick Leadbeater, has begun offering ... Dr. Leadbeater, of Kahala Pet Hospital on Oahu, is a skilled surgeon ... to the island of Kauai on an almost weekly basis to perform surgery at ...
Breaking Biology Technology:
Cached News: