HOME >> BIOLOGY >> NEWS
New approach offers potential drug-discovery shortcut

Researchers at Massachusetts General Hospital have developed a way of identifying promising new drugs that may get around a major challenge in drug discovery. In the May issue of Nature Biotechnology the team from the MGH Cardiovascular Research Center (CVRC) describes using an animal model to screen for a compound that suppresses a serious genetic mutation. Their success did not rely on first identifying a molecular target for the new drug, something that is a key bottleneck in current procedures. The study is being released today on the journal's website.

"Currently most drugs are designed to act on a specific protein, but for most diseases we still don't know what the protein targets should be," says Randall Peterson, PhD, of the MGH CVRC, the paper's lead author. "This is a totally different approach that shows how, without knowing the best target, you can screen for drugs that could reverse a disease and in the process learn something new about the underlying biology."

The researchers started with embryos of zebrafish a tiny tropical fish used as a model of vertebrate development with a mutation called gridlock, which prevents the correct development of the circulatory system in the lower portion of the body. A panel of these embryos was exposed to a very diverse library of small molecules 5,000 in all to see if any would prevent expression of the gridlock mutation. Two similar molecules were identified that suppressed the mutation, allowing the embryos to develop normally. The one that appeared more powerful, called GS4012, was chosen for further study.

The gridlock-suppressing effects of GS4012 were found to vary with dosage, and no vascular abnormalities were seen at the doses studied. Application of the compound appeared to be most effective at a developmental stage right before and during the formation of major vascular structures. Further experiments showed that GS4012 appears to promote the activity of the angiogene
'"/>

Contact: Sue McGreevey
smcgreevey@partners.org
617-724-2764
Massachusetts General Hospital
18-Apr-2004


Page: 1 2

Related biology news :

1. Belgian researchers explore revolutionary approach to angiogenesis
2. Novel IBD therapeutic approaches reported from Washington Univ., Barcelona, LSU at APS meeting
3. Researchers recommend new approach to combat drug-resistant staph infections
4. U. Iowa muscular dystrophy discovery may lead to new treatment approaches
5. New research suggests therapeutic approach for autoimmune diseases
6. New approach limits damage after heart attack and improves survival, say Scripps Research scientists
7. Steroid-coated DNA represents new approach to gene delivery
8. Two-drug approach might shorten painful labor, reduce Caesarean sections
9. Death-defying approach devised by Penn scientists to prevent cell apoptosis
10. Smallpox in 50-year-old tissues detected by integrated diagnostics approach
11. One-size-fits-all approach to nutrition recommendations may soon be outdated

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/3/2018)... ... October 03, 2018 , ... Orbsen ... first-in-class stromal cell immunotherapies, announced that ORBCEL-M™, a second generation stromal cell ... progressive diabetic kidney disease in a four-site, pan-European Phase I/II clinical trial. ...
(Date:10/2/2018)... (PRWEB) , ... October 02, 2018 , ... Through this ... for 1536-well FLIPR screening. They will also learn the role of calcium kinetics in ... Hurk, the chief operations officer at PPSC Biography; and Tsang Wai Lam, an assay ...
(Date:10/1/2018)... ... October 01, 2018 , ... NanoValent Pharmaceuticals, Inc ., ... based therapeutics, today announced the National Institute of Health (NIH) ... year funding for two separate grants. These two grants will allow NanoValent to ...
Breaking Biology News(10 mins):
(Date:10/16/2018)... ... October 16, 2018 , ... Infinity ... Congressional briefing on a revolutionary technology that effectively treats pain, reduces the need ... Healing, testified on how technology using photobiomodulation (PBM) has been effective for the ...
(Date:10/16/2018)... ... 15, 2018 , ... The American Medical Informatics Association (AMIA) is proud to ... awards at the AMIA 2018 Annual Symposium , taking place Nov. 3 – ... year garnered more than 700 submissions. The AMIA Signature Awards program provides an opportunity ...
(Date:10/11/2018)... ... 10, 2018 , ... Boston Biotech Conferences, creator of exclusive ... PhD, as its new CEO. , Dr. Nelson has over 20 years of ... Most recently, Dr. Nelson was VP of Business Development, Marketing and Strategic Alliances ...
(Date:10/11/2018)... Calif. (PRWEB) , ... October 11, 2018 , ... ... and short-run label printing and software solutions, in collaboration with HP, the global ... certification for Avery UltraDuty GHS Chemical Labels on all HP PageWide Printers. , ...
Breaking Biology Technology:
Cached News: