New cell line increases research opportunities

Researchers at Georgetown University Medical Center and colleagues have developed a germ cell line derived from spermatogonia, the stem cells that produce sperm. This cell line can proliferate for extended periods in a laboratory setting and will be used for the future study of many medical problems related to sperm. The Georgetown findings have been published on SciencExpress, a web site of the journal Science that provides rapid electronic publication of novel and important findings.

This cell line will provide a basic tool for scientists at Georgetown and elsewhere who are working on male infertility problems, testicular cancer, and possibly for germ cell gene therapy. Germ cell gene therapy is a form of gene therapy that involves altering the genetic makeup of eggs or sperm, permanently changing the genome of an individual's offspringas opposed to standard gene therapy, which supplies cells with healthy copies of missing or altered genes and affects only the person receiving the therapy. This particular cell line was derived from mice, and from stem cells that can only become sperm cells; it is not derived from human embryos.

Unlike previously developed spermatogonial cell lines, this cell line exhibits characteristic features of normal adult spermatogonial stem cells and, upon appropriate stimulation, differentiates into advanced germ cell types. Further studies with this cell line may lead to in vitro sperm production (a test tube testis), allowing scientists to study the process of male gamete formation more closely.

"The potential implications of this cell line for germ cell gene therapy are far-reaching, although this technology will require many more years of study before it is ready for humans," said Martin Dym, PhD, chair of cell biology and senior author on this work. "Scientists may one day be able to remove defective genes in the sperm stem cells that cause diseases such as cystic fibrosis or hemophilia, transplant the

Contact: Beth Porter
Georgetown University Medical Center

Page: 1 2

Related biology news :

1. USC study links historical increases in life span to lower childhood exposure to infection
2. Moderate alcohol consumption increases plasma levels of a protective hormone
3. Protease-inhibitor cocktail protects, increases anti-microbial action of promising new peptide
4. Breast self examination increases womens concerns but has no effect on mortality
5. Educational program increases some safety behaviors for older drivers
6. Placental malaria increases mother-to-child HIV transmission
7. NIEHS-funded researchers find low-level ozone increases respiratory risk of asthmatic children
8. Northwesterns Cancer Genetics Program pinpoints gene that increases cancer risk by 26 percent
9. Common gene variant increases risk of atherosclerosis
10. Prenatal exposure to nicotine increases risk of apnea in brains of newborn rats
11. Drug combination increases life span of mice with ALS

Post Your Comments:

(Date:8/26/2020)... , ... August 25, 2020 , ... Modality Solutions, ... Inc. magazine’s 2020 annual Inc. 5000 list. The list is the most prestigious ranking ... 2019 as well, and for this year’s list, reported three-year revenue growth of 71 ...
(Date:8/21/2020)... Virginia (PRWEB) , ... August 20, 2020 , ... ... today that Hassan Movahhed , a Clinical Operations executive with expertise in ... management, has joined the firm as an Expert Consultant. Throughout his career, Mr. ...
(Date:8/5/2020)... ... 05, 2020 , ... Regenative Labs has received approval from the Centers for ... them the first Wharton’s jelly allografts to be assigned a Q code and be ... the first Wharton’s jelly allograft product to be recognized as a 361 HCT/P by ...
Breaking Biology News(10 mins):
(Date:9/1/2020)... Va. (PRWEB) , ... September 01, 2020 , ... ... for life sciences, biotechnology, and diagnostics companies, has announced the placement of ... Averill will be responsible for leading all financial operations and implementing key business ...
(Date:8/15/2020)... ... 13, 2020 , ... Inc. magazine today revealed that Skysis ... of the nation’s fastest-growing private companies. The list represents a unique look at ... businesses. Intuit, Zappos, Under Armour, Microsoft, Patagonia, and many other well-known names gained ...
(Date:8/12/2020)... ... August 12, 2020 , ... Inc. magazine today ... leader in FDA compliance consulting has been named on its annual Inc. 5000 ... represents a unique look at the most successful companies within the American economy’s ...
(Date:8/3/2020)... ... 2020 , ... Introducing Ardent Animal Health – MediVet Biologics rebrands company and ... Known as MediVet Biologics since its formation in 2016, the company is relaunching itself ... will build on its base of innovative therapies for osteoarthritis and cancer. ...
Breaking Biology Technology:
Cached News: