P> Knowing that Rora is a component of the mammalian clock is significant because it may be a valuable target for the development of compounds to correct sleep disorders, many of which are related to circadian rhythms, and for countering the most common circadian problems -- the jet-lag one feels after overseas flights or fatigue when working night shifts.

"Identifying a ligand for Rora might help reduce the effects of jet lag," says Sato.

The article, "A Functional Genomics Strategy Reveals Rora as a Component of the Mammalian Circadian Clock" was authored by Trey K. Sato, Satchidananda Panda, Loren J. Miraglia, Teresa M. Reyes, Radu D. Rudic, Peter McNamara, Kinnery A. Naik, Garret A. FitzGerald, Steve A. Kay, and John B. Hogenesch and appears in the August 19, 2004 issue of the journal Neuron.

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Contact: Keith McKeown
kmckeown@scripps.edu
858-784-8134
Scripps Research Institute
18-Aug-2004

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