New components of machinery that carries genetic information from nucleus

DURHAM, N.C. -- Researchers have reported discovering the first elements of what is apparently a molecular signaling pathway important for regulating how genetic information leaves the nucleus to begin its working life as a blueprint for the cell.

According to the scientists, their finding represents an intriguing new role for a signaling molecule, derived from inositol, in the cell.

In an article in the July 2 Science, Duke University Medical Center pharmacologist John York and his colleagues reported studies in yeast that revealed the presence of enzymes called kinases ? enzymes that add phosphates to inositol to make them into signals that trigger the export of messenger RNA from the cell nucleus.

Messenger RNA (mRNA) is the molecule that, when copied from DNA genes in the nucleus, carries genetic information into the cell where it is used to build proteins.

Co-authors on the article are Audrey Odom, also of Duke, and Robert Murphy, Eric Ives and Susan Wente of Washington University School of Medicine. York is an assistant professor of pharmacology and cancer biology, and of biochemistry. Odom is a graduate student in the Medical Scientist Training Program. The research was sponsored by the Burroughs Wellcome Fund, the National Institutes of Health and the American Cancer Society.

While York emphasizes that the discovery is very basic in nature, and was made using yeast, such fundamental knowledge invariably contributes to understanding and treatment of human disease, he said. Particularly important, he emphasized, is that inositol signaling is critical to the machinery of living cells, and many of its components are conserved all the way from yeast to humans.

Inositols had already been suspected of being major signaling molecules in the cell, because some 20 different inositols had been discovered with varying numbers and arrangements of phosphates attached, like a multitude of

Contact: Dennis Meredith
Duke University

Page: 1 2 3

Related biology news :

1. Researchers look into components of RNA silencing machinery
2. Lycopenes anti-cancer effect linked to other tomato components
3. Scientists switch components in cell circuits: Possible new technology, therapy
4. New understanding of the machinery of flinching
5. How DNA repair machinery is a Two-Way Street
6. Budding viral hijackers may co-opt cell machinery for the getaway
7. Nitric oxide may change basic understanding of cellular machinery
8. Pattern recognition method zeroes in on genes that regulate cells genetic machinery
9. Computational method identifies genes that regulate cells machinery
10. Study of natures machinery takes center stage at UH
11. Discovery of how prolactin travels to genes machinery helps explain its role in breast cancer

Post Your Comments:

(Date:9/17/2019)... CITY (PRWEB) , ... September 17, 2019 , ... ... and a group of doctors, scientists and engineers from the Medical University of ... the results of their work to-date in creating a neuroprosthetic system as part ...
(Date:9/14/2019)... , ... September 13, 2019 , ... ... imaging Society (WMIS) focused on non-invasive real-time tracking of gene therapy and advances ... of five years (and most cases fatal) lysomal storage diseases (LSD) are among ...
(Date:9/8/2019)... Md. (PRWEB) , ... September ... ... biotechnology market disrupter and leading supplier of innovative human mesenchymal stem/stromal cell ... first human umbilical cord (hUC) MSC paired cell and media system designed ...
Breaking Biology News(10 mins):
(Date:10/10/2019)... (PRWEB) , ... October 09, 2019 , ... ... 10th, groups of Montgomery County middle school and high school students have improved ... stressors, utilize relaxation techniques and physical fitness, and apply lifelong social/interpersonal, leadership, problem-solving ...
(Date:10/10/2019)... Ariz. (PRWEB) , ... October 10, 2019 , ... ... Pratia , the largest network of clinical research centers in Europe. All Pratia ... site network in Europe to become trained and certified as Virtual Trial Capable ...
(Date:10/8/2019)... ... October 07, 2019 , ... Erchonia Corporation, the global leader ... announces that the U.S. Food and Drug Administration (FDA) has granted the company ... relief of chronic neck and shoulder pain of musculoskeletal origin. , Erchonia continues ...
(Date:10/3/2019)... , ... October 01, 2019 , ... ... relax and reset itself, announced the midway point of its randomized research trial ... the study is to measure the efficacy of a non-invasive technology which compares ...
Breaking Biology Technology:
Cached News: