HOME >> BIOLOGY >> NEWS
New compound could give some types of cancer the one-two punch

PHILADELPHIA Ohio State University researchers are working on developing a multi-purpose cancer drug that might one day scale back the number of medications some cancer patients need to take.

In laboratory tests, a dual-action compound called OSU 111 has shown promise in killing prostate cancer cells.

"It had a direct toxic effect on cancer cells, and also prevented angiogenesis the formation of new blood vessels from pre-existing ones," said Tom Li, the study's lead investigator and an associate professor of pharmacy at Ohio State.

"It's like using one stone to kill two birds."

Li presented the results on August 22 in Philadelphia at the summer meeting of the American Chemical Society.

OSU 111 is a variation on a theme Li and his colleagues created OSU 111 using a known anti-cancer compound, SU-5416, as a model. Although SU-5416 showed promise in preclinical studies, it did not have the kind of far-reaching effectiveness that researchers had hoped for.

--------------------------------------------------------------------------------

"One drug with dual activity means that the body only has to deal with a single compound, and that could eliminate a lot of complexity in terms of giving medication to patients, the body's ability to absorb a drug and also side effects."

--------------------------------------------------------------------------------

But SU-5416 does provide a good blueprint by which researchers can create dozens of analogs compounds structurally similar, but with slightly different chemical compositions.

"We've made close to 50 different analogs by modifying SU-5416," Li said.

Laboratory experiments show that OSU 111 is one of the most promising analogs for killing cancer cells Li's team has found so far. When treated with OSU 111 in laboratory experiments, the majority of prostate cancer tissue cells died within three days, Li said.

"This compound stopp
'"/>

Contact: Tom Li
li.27@osu.edu
614-688-0253
Ohio State University
22-Aug-2004


Page: 1 2 3

Related biology news :

1. Anti-cancer compound in vegetables found to block late-stage breast-cancer cell growth
2. NJIT chemist speaks Aug. 25 about compound derived from pine tree
3. Scientists identify compounds that mimic calorie restriction
4. Firefly compound lights up protein dance in living animals
5. New compound highly efficacious at reducing human tumour growth
6. Wilex & Fox Chase Cancer Center begin trial w/ novel compound targeting tumor invasion & metastasis
7. New screening method turns up potential compound for treating anthrax
8. New, non-radioactive screen for antimalarial compounds
9. OHSU team discovers compound that lacks estrogens risks
10. Three molecular-targeted compounds show promise against cancers
11. New compound library to speed drug discovery

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: New compound could give some types cancer the one two punch

(Date:5/23/2013)... the world,s most popular fruit, can be made both ... GM varieties. , "Working with GM tomatoes that ... of a specific compound, allows us to pinpoint exactly ... Martin from the John Innes Centre. , The research ... health and shelf life characteristics because even higher levels ...
(Date:5/23/2013)... than 13,000 ships per year, carrying more than 284 million ... roughly $1.8 billion dollars in toll fees for the Panama ... 55 million gallons of water are used from Gatun Lake, ... million people living in the isthmus. , However, the ... 20 percent of the ships at sea, has demanded change. ...
(Date:5/23/2013)... By discovering the new mechanism by which estrogen suppresses ... revealed a potential new approach toward treating certain liver ... and colleagues believe they are changing long-held views in ... issue of the journal Science Signaling . , ... years has been that only receptors located in the ...
Breaking Biology News(10 mins):The world's favorite fruit only better-tasting and longer-lasting 2Reforestation study shows trade-offs between water, carbon and timber 2Reforestation study shows trade-offs between water, carbon and timber 3UCI study reveals new mechanism for estrogen suppression of liver lipid synthesis 2
(Date:5/24/2013)... May 24, 2013 Quincy Bioscience, ... and development of calcium-binding proteins to support healthy ... safety assessment study of apoaequorin in ... published for the British Industrial Biological Research Association. ... to investigate potential adverse effects, if any, of ...
(Date:5/23/2013)... , May 23, 2013  BioScrip, Inc. (NASDAQ: ... present at the Jefferies 2013 Global Healthcare Conference to ... New York. Richard Smith ... Hai Tran , Chief Financial Officer, will present ... Daylight Time.   About BioScrip BioScrip, ...
(Date:5/23/2013)... 23, 2013 PuraMed BioScience ® , ... of over-the-counter (OTC) medicinal and healthcare products, announced ... the company based on low market capitalization valuation. ... All Natural Product to Treat Migraine Headaches ... Prescription Competitor , Currently Available Nationwide at ...
(Date:5/23/2013)... May 23, 2013 VG Energy, an ... with DAK Renewable Research to conduct field trials ... VG Energy is a majority owned subsidiary of ... VG Energy,s exclusively licensed compound LipidMax selectively ... yield in plants, possessing a wide variety of ...
Breaking Biology Technology:Safety Assessment Study of Apoaequorin Published in Food and Chemical Toxicology 2PuraMed BioScience (PMBS) Issued Alert Based on Market Cap of $721,756 2PuraMed BioScience (PMBS) Issued Alert Based on Market Cap of $721,756 3VG Energy Enters into a Strategic Alliance with DAK Renewable Research for LipidMax Field Trials 2VG Energy Enters into a Strategic Alliance with DAK Renewable Research for LipidMax Field Trials 3
Cached News: