HOME >> BIOLOGY >> NEWS
New compound could give some types of cancer the one-two punch

PHILADELPHIA Ohio State University researchers are working on developing a multi-purpose cancer drug that might one day scale back the number of medications some cancer patients need to take.

In laboratory tests, a dual-action compound called OSU 111 has shown promise in killing prostate cancer cells.

"It had a direct toxic effect on cancer cells, and also prevented angiogenesis the formation of new blood vessels from pre-existing ones," said Tom Li, the study's lead investigator and an associate professor of pharmacy at Ohio State.

"It's like using one stone to kill two birds."

Li presented the results on August 22 in Philadelphia at the summer meeting of the American Chemical Society.

OSU 111 is a variation on a theme Li and his colleagues created OSU 111 using a known anti-cancer compound, SU-5416, as a model. Although SU-5416 showed promise in preclinical studies, it did not have the kind of far-reaching effectiveness that researchers had hoped for.

--------------------------------------------------------------------------------

"One drug with dual activity means that the body only has to deal with a single compound, and that could eliminate a lot of complexity in terms of giving medication to patients, the body's ability to absorb a drug and also side effects."

--------------------------------------------------------------------------------

But SU-5416 does provide a good blueprint by which researchers can create dozens of analogs compounds structurally similar, but with slightly different chemical compositions.

"We've made close to 50 different analogs by modifying SU-5416," Li said.

Laboratory experiments show that OSU 111 is one of the most promising analogs for killing cancer cells Li's team has found so far. When treated with OSU 111 in laboratory experiments, the majority of prostate cancer tissue cells died within three days, Li said.

"This compound stopp
'"/>

Contact: Tom Li
li.27@osu.edu
614-688-0253
Ohio State University
22-Aug-2004


Page: 1 2 3

Related biology news :

1. Anti-cancer compound in vegetables found to block late-stage breast-cancer cell growth
2. NJIT chemist speaks Aug. 25 about compound derived from pine tree
3. Scientists identify compounds that mimic calorie restriction
4. Firefly compound lights up protein dance in living animals
5. New compound highly efficacious at reducing human tumour growth
6. Wilex & Fox Chase Cancer Center begin trial w/ novel compound targeting tumor invasion & metastasis
7. New screening method turns up potential compound for treating anthrax
8. New, non-radioactive screen for antimalarial compounds
9. OHSU team discovers compound that lacks estrogens risks
10. Three molecular-targeted compounds show promise against cancers
11. New compound library to speed drug discovery

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/16/2018)... ... October 16, 2018 , ... Nanomedical Diagnostics , ... new publication titled, “ Graphene-based Biosensor for On-Chip Detection of Bio-Orthogonally Labeled Proteins ... as a “new portable digital device for biosensing… that can be employed for ...
(Date:10/11/2018)... ... October 09, 2018 , ... ? ... market-ready technologies expedite their path to health system adoption and insurer reimbursement, ? ... across all major EHR applications, enabling them to focus on innovation not integration, ...
(Date:10/11/2018)... ... October 11, 2018 , ... ODSC Europe 2018 - ... 100% increase in attendance at the event from September 19-22. , As Europe’s ... intelligence sessions across 10 tracks and 4 days. Attendees were given key insights and ...
Breaking Biology News(10 mins):
(Date:10/2/2018)... (PRWEB) , ... October 02, 2018 , ... ... and Locus Bio-Energy Solutions™, LLC’s (Locus Bio-Energy) AssurEOR product line was chosen for ... Oil and Gulf Energy Information, honor leading innovations in upstream oil applications that ...
(Date:10/2/2018)... ... October 02, 2018 , ... ... this week that teams have initiated validation of standards and testing of procedures ... direction of Dr. Larry Kennedy, ACRES VP for Quality Management Systems and Chief ...
(Date:9/28/2018)... ... September 28, 2018 , ... ... to increase the availability of the GlycoMark test, the only FDA-cleared blood test ... the partnership, PMLS will promote and offer the GlycoMark test to its network ...
(Date:9/27/2018)... ... 26, 2018 , ... NDA Partners Chairman Carl Peck, ... and in vitro diagnostic device expert with more than 28 years of experience ... as an Expert Consultant. Her experience includes leadership roles in regulatory strategy, quality ...
Breaking Biology Technology:
Cached News: