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New computational tools to aid in protein research

and Donald's technique assigns the measurements to the correct nuclei, which helps to unveil the architecture of the protein.

A second paper by Donald and Lincong Wang, a Dartmouth post-doctoral fellow, will be published in July 2004. This paper describes a new protein structure determination algorithm, which solves complex algebraic equations that relate the experimental data to the protein's geometry. "Our algorithm requires less data and yet the resulting protein structures are incredibly accurate," says Donald. Unlike previous techniques, Wang's equations can be solved exactly in a manner similar to solving the quadratic equation of high school algebra fame. Wang and Donald hope that their work proves helpful to both structural genomic researchers as well as to those in the broader structural biology field.


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Contact: Sue Knapp
Sue.Knapp@dartmouth.edu
603-646-3661
Dartmouth College
23-Jun-2004


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