HOME >> BIOLOGY >> NEWS
New depression studies reveal persistent serotonin system abnormality in patients

CHAPEL HILL About 10 years ago, Dr. Robert Golden and University of North Carolina at Chapel Hill colleagues discovered an important new clue to the cause of depression, one that other researchers eventually confirmed.

They found that depressed people showed a blunted hormonal response to a test he developed that boosts serotonin, an important neurotransmitter chemical in the brain.

"This neuroendocrine challenge test, which involved giving depressed volunteer patients a medicine called clomipramine, indicated that depressed patients serotonin systems were sluggish in response and not working efficiently," Golden said. "An analogy I use is that their serotonin engine needs a tune-up because they arent getting much mileage out of the gas being burned."

Now, newly published work by his laboratory shows that as a group, people suffering from the illness have that biological abnormality even when they are not depressed.

"We believe this work is an important step forward in our understanding of depression because it demonstrates an ongoing trait that distinguishes patients who have had the illness from the rest of the population," he said. "It is strong evidence that depression reflects a genetic trait, which clinicians have believed for a long time because depression tends to run in families."

Golden is professor and chair of psychiatry at the UNC School of Medicine. In February next year, he will receive the American College of Psychiatrists annual award for contributions to mood disorders research.

A report on the findings appears in the May issue of Neuropsychopharmacology, a scientific journal. Besides Golden, authors include biostatistician R. David Ekstrom, Drs. Joseph M. Bebchuk and Martha E. Leatherman, both former postdoctoral fellows, and Dr. James C. Garbutt, professor of psychiatry.

One of the bodys most important neurotransmitters, serotonin helps regulate many emotional and physiologic functi
'"/>

Contact: David Williamson
david_williamson@unc.edu
919-962-8596
University of North Carolina at Chapel Hill
28-May-2002


Page: 1 2 3

Related biology news :

1. Alcohol-use and depression among pregnant and postpartum women
2. Scientists build on case connecting inflammatory disease and depression
3. Severe depression associated with greater number of nerve cells in thalamus region of brain
4. UT Southwestern researchers study benefit of exercise, medication on depression
5. Common treatment for depression is safe and effective for Alzheimers patients
6. Study suggests interplay of gene, stress can predict depression
7. Gene more than doubles risk of depression following life stresses
8. Gene helps determine whether the stresses of life push you into depression, Science study says
9. A sex-specific gene for depression
10. Pitt researchers find genes for depression; Play role in mood disorders, shorter lifespan
11. Many pregnant women may have depression, but few getting treatment, study finds

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/11/2017)... NEW BRUNSWICK, N.J. , Jan. 11, 2017  Michael Johnson, ... from Foundation Venture Capital Group, Inc., has been named to the ... Johnson, 27,  was one of 600 people in 20 fields ... only four percent of the 15,000 applicants were selected. ... He is currently a PhD ...
(Date:1/4/2017)... 4, 2017  CES 2017 – Valencell , ... today announced the launch of two new versions ... highly-accurate biometric sensor modules that incorporate the best ... and expertise. The two new designs include Benchmark ... hearables, and Benchmark BW2.0, a 2-LED version of ...
(Date:12/20/2016)... RALEIGH, N.C. and GENEVA, Dec, 20, 2016 ... performance biometric data sensor technology, and STMicroelectronics ... across the spectrum of electronics applications, announced today ... scalable development kit for biometric wearables that includes ... integrated with Valencell,s Benchmark™ biometric sensor ...
Breaking Biology News(10 mins):
(Date:1/19/2017)... SHANGHAI , Jan. 19, 2017 /PRNewswire -- ... medical device open-access capability and technology platform, today ... a leading biology focused preclinical drug discovery contract ... Biosciences will become a wholly-owned subsidiary of WuXi, ... core competences and providing greater services. The acquisition ...
(Date:1/19/2017)... , ... January 19, 2017 , ... ... product vigilance software to leading biopharmaceutical and medical device manufacturers and regulators, is ... fully 21 CFR Part 11-compliant email client designed to provide product vigilance departments ...
(Date:1/19/2017)... 2017 AquaBounty Technologies, Inc. (AIM: ABTU; NASDAQ: ... aquaculture and a majority-owned subsidiary of Intrexon Corporation (NYSE: ... the listing of its common shares on the NASDAQ ... "AquaBounty,s listing on NASDAQ represents an important ... to the U.S. markets as we advance plans for ...
(Date:1/19/2017)... ... January 19, 2017 , ... FireflySci Inc. is a go-getter type of ... growth is accounted to two main factors. The first is the amazing customer ... vendors supplying FireflySci products all around the world. , 2016 was a tremendous sales ...
Breaking Biology Technology:
Cached News: