HOME >> BIOLOGY >> NEWS
New depression studies reveal persistent serotonin system abnormality in patients

CHAPEL HILL About 10 years ago, Dr. Robert Golden and University of North Carolina at Chapel Hill colleagues discovered an important new clue to the cause of depression, one that other researchers eventually confirmed.

They found that depressed people showed a blunted hormonal response to a test he developed that boosts serotonin, an important neurotransmitter chemical in the brain.

"This neuroendocrine challenge test, which involved giving depressed volunteer patients a medicine called clomipramine, indicated that depressed patients serotonin systems were sluggish in response and not working efficiently," Golden said. "An analogy I use is that their serotonin engine needs a tune-up because they arent getting much mileage out of the gas being burned."

Now, newly published work by his laboratory shows that as a group, people suffering from the illness have that biological abnormality even when they are not depressed.

"We believe this work is an important step forward in our understanding of depression because it demonstrates an ongoing trait that distinguishes patients who have had the illness from the rest of the population," he said. "It is strong evidence that depression reflects a genetic trait, which clinicians have believed for a long time because depression tends to run in families."

Golden is professor and chair of psychiatry at the UNC School of Medicine. In February next year, he will receive the American College of Psychiatrists annual award for contributions to mood disorders research.

A report on the findings appears in the May issue of Neuropsychopharmacology, a scientific journal. Besides Golden, authors include biostatistician R. David Ekstrom, Drs. Joseph M. Bebchuk and Martha E. Leatherman, both former postdoctoral fellows, and Dr. James C. Garbutt, professor of psychiatry.

One of the bodys most important neurotransmitters, serotonin helps regulate many emotional and physiologic functi
'"/>

Contact: David Williamson
david_williamson@unc.edu
919-962-8596
University of North Carolina at Chapel Hill
28-May-2002


Page: 1 2 3

Related biology news :

1. Alcohol-use and depression among pregnant and postpartum women
2. Scientists build on case connecting inflammatory disease and depression
3. Severe depression associated with greater number of nerve cells in thalamus region of brain
4. UT Southwestern researchers study benefit of exercise, medication on depression
5. Common treatment for depression is safe and effective for Alzheimers patients
6. Study suggests interplay of gene, stress can predict depression
7. Gene more than doubles risk of depression following life stresses
8. Gene helps determine whether the stresses of life push you into depression, Science study says
9. A sex-specific gene for depression
10. Pitt researchers find genes for depression; Play role in mood disorders, shorter lifespan
11. Many pregnant women may have depression, but few getting treatment, study finds

Post Your Comments:
(Date:10/15/2014)... and to an unexpected extent. The outbreak does not ... virus shows a new disease dynamic in regions, where ... the German National Academy of Sciences Leopoldina, acatech – ... Union of the German Academies of Sciences and Humanities ... , In the statement the academies call for the ...
(Date:10/15/2014)... Rosenstiel Award for Distinguished Work in Biomedical Science by ... of genomic instability and its implications for the immune ... to win the Rosenstiel Award; the first, Rod McKinnon, ... the Charles A. Janeway Professor of Pediatrics and Professor ... at the Howard Hughes Medical Institute at Boston Children,s ...
(Date:10/14/2014)... published in Cancer Research shows SIRT6—a protein ... cancers—can promote the development of skin cancers by turning ... of sun-damaged skin cells. , Previously considered protective, SIRT6 ... sirtuins that help regulate genomic stability and prevent some ... repair DNA damage, which can lead to cancer. This ...
Breaking Biology News(10 mins):Academies call for consequences from the Ebola virus epidemic 2Academies call for consequences from the Ebola virus epidemic 3Academies call for consequences from the Ebola virus epidemic 4Academies call for consequences from the Ebola virus epidemic 5Brandeis awards 44th Rosenstiel Award to pioneering geneticist Fred Alt 2Two-faced gene: SIRT6 prevents some cancers but promotes sun-induced skin cancer 2
(Date:10/20/2014)... The report “Pharmacy Automation Systems Market by ... Systems, Table-top Counters) by End-user (Inpatient Pharmacy Automation, ... to 2019” analyzes and studies the major market ... Asia-Pacific, and the Rest of the World (RoW). ... spread through 300 pages and in-depth TOC on ...
(Date:10/20/2014)... (PRWEB) October 20, 2014 Convey ... that a team from Iowa State University won first ... contest. Using a Convey HC-2ex, the team’s solution achieved ... times faster than the second place finisher. , Experts ... embarked upon the month long challenge, using a variety ...
(Date:10/20/2014)... ON , Oct. 20, 2014 /PRNewswire/ - BIOREM Inc. (TSXV: ... $1.7 million which brings Q3 orders to $5.8 million and provides ... control projects in North America and one ... continue to bid new projects at record levels," said Peter ... were higher at the end of Q3 than they have been ...
(Date:10/20/2014)... , Oct. 20, 2014  GenVec, Inc. (NASDAQ: ... P. Horovitz , Ph.D., from its board of directors effective ... in August 2003, and served as its chairman from June ... on the Nominating and Corporate Governance and Audit Committees of ... more than a decade of dedicated service to GenVec, and ...
Breaking Biology Technology:Pharmacy Automation Systems Market worth $4,566.2 Million by 2019 - New Research Report by MarketsandMarkets 2Pharmacy Automation Systems Market worth $4,566.2 Million by 2019 - New Research Report by MarketsandMarkets 3Pharmacy Automation Systems Market worth $4,566.2 Million by 2019 - New Research Report by MarketsandMarkets 4Team from Iowa State Wins 2014 MemoCODE Design Contest Using Convey HC-2ex 2Team from Iowa State Wins 2014 MemoCODE Design Contest Using Convey HC-2ex 3Zola P. Horovitz To Retire From GenVec Board 2
Cached News: