HOME >> BIOLOGY >> NEWS
New depression studies reveal persistent serotonin system abnormality in patients

CHAPEL HILL About 10 years ago, Dr. Robert Golden and University of North Carolina at Chapel Hill colleagues discovered an important new clue to the cause of depression, one that other researchers eventually confirmed.

They found that depressed people showed a blunted hormonal response to a test he developed that boosts serotonin, an important neurotransmitter chemical in the brain.

"This neuroendocrine challenge test, which involved giving depressed volunteer patients a medicine called clomipramine, indicated that depressed patients serotonin systems were sluggish in response and not working efficiently," Golden said. "An analogy I use is that their serotonin engine needs a tune-up because they arent getting much mileage out of the gas being burned."

Now, newly published work by his laboratory shows that as a group, people suffering from the illness have that biological abnormality even when they are not depressed.

"We believe this work is an important step forward in our understanding of depression because it demonstrates an ongoing trait that distinguishes patients who have had the illness from the rest of the population," he said. "It is strong evidence that depression reflects a genetic trait, which clinicians have believed for a long time because depression tends to run in families."

Golden is professor and chair of psychiatry at the UNC School of Medicine. In February next year, he will receive the American College of Psychiatrists annual award for contributions to mood disorders research.

A report on the findings appears in the May issue of Neuropsychopharmacology, a scientific journal. Besides Golden, authors include biostatistician R. David Ekstrom, Drs. Joseph M. Bebchuk and Martha E. Leatherman, both former postdoctoral fellows, and Dr. James C. Garbutt, professor of psychiatry.

One of the bodys most important neurotransmitters, serotonin helps regulate many emotional and physiologic functi
'"/>

Contact: David Williamson
david_williamson@unc.edu
919-962-8596
University of North Carolina at Chapel Hill
28-May-2002


Page: 1 2 3

Related biology news :

1. Alcohol-use and depression among pregnant and postpartum women
2. Scientists build on case connecting inflammatory disease and depression
3. Severe depression associated with greater number of nerve cells in thalamus region of brain
4. UT Southwestern researchers study benefit of exercise, medication on depression
5. Common treatment for depression is safe and effective for Alzheimers patients
6. Study suggests interplay of gene, stress can predict depression
7. Gene more than doubles risk of depression following life stresses
8. Gene helps determine whether the stresses of life push you into depression, Science study says
9. A sex-specific gene for depression
10. Pitt researchers find genes for depression; Play role in mood disorders, shorter lifespan
11. Many pregnant women may have depression, but few getting treatment, study finds

Post Your Comments:
(Date:8/6/2015)... , Aug. 6, 2015  Today, U.S. ... visit Crossmatch ™ to learn firsthand how ... protect data. Crossmatch is a world leader in ... and expertise are helping federal agencies and commercial ... security.   "The vast majority of ...
(Date:8/5/2015)... Transparency Market Research has released ... Global Industry Analysis, Size, Share, Growth, Trends and Forecast ... is forecast to reach US$ 2,671.8 Mn by 2022. ... systems by civil and government agencies. This is majorly ... activities across the globe that would elevate the demand ...
(Date:8/3/2015)... SAN JOSE, Calif. , Aug. 3, 2015 /PRNewswire/ ... developer of human interface solutions, today announced that members ... investment community at the Pacific Crest Global Technology Leadership ... Mountain Time. The conference will be held at the ... The presentation may include forward-looking information. ...
Breaking Biology News(10 mins):Rep. Honda to Visit Crossmatch in Redwood City 2Facial Recognition Market Expected to Reach US$ 2.67 Bn by 2022, at a CAGR of 9.5% From 2015 - 2022: Transparency Market Research 2Facial Recognition Market Expected to Reach US$ 2.67 Bn by 2022, at a CAGR of 9.5% From 2015 - 2022: Transparency Market Research 3Facial Recognition Market Expected to Reach US$ 2.67 Bn by 2022, at a CAGR of 9.5% From 2015 - 2022: Transparency Market Research 4Facial Recognition Market Expected to Reach US$ 2.67 Bn by 2022, at a CAGR of 9.5% From 2015 - 2022: Transparency Market Research 5Facial Recognition Market Expected to Reach US$ 2.67 Bn by 2022, at a CAGR of 9.5% From 2015 - 2022: Transparency Market Research 6
(Date:8/28/2015)... ... August 28, 2015 , ... Pittcon is pleased ... present a session on chemical spectroscopic imaging at JASIS 2015 (Japan Analytical & ... largest analytical and scientific instruments show which will be held at International Conference ...
(Date:8/28/2015)... ... August 28, 2015 , ... Since the initial launch of FireflySci Inc. (FFS) in early ... excellent customer service. Images such as the Fonz in a lab coat and Large ... to the humdrum spectroscopy field. , FireflySci is proud to be the only ...
(Date:8/27/2015)... Aug. 27, 2015  Neogen Corporation (NASDAQ: NEOG ... of United Kingdom -based Lab M ... media and diagnostic systems. Lab M ... leading provider of microbial testing and diagnostic products for ... The company currently sells into more than 70 countries ...
(Date:8/27/2015)...  Asterias Biotherapeutics, Inc. (NYSE MKT: AST), a leading ... today announced that executives from the company will present ... , Pedro Lichtinger , Chief ... Annual Global Investment Conference on Wednesday, September 10, 2015 ... in New York City . ...
Breaking Biology Technology:U.S. Symposium on Imaging Organized by Pittcon’s Program Chairman Chuck Gardner 2U.S. Symposium on Imaging Organized by Pittcon’s Program Chairman Chuck Gardner 3Cuvette Manufacturer FireflySci Launches Back to School Deals with Complimentary Shipping On All Orders 2Neogen acquires U.K.-based Lab M Holdings 2Asterias Biotherapeutics to Present at Upcoming Investor Conferences 2
Cached News: