HOME >> BIOLOGY >> NEWS
New discovery may help transplants survive

Boston, MA For the first time scientists have found that a growth factor called vascular endothelial growth factor receptor-3 (VEGFR-3), known to cause the growth of lymphatic vessels in the body, controls how immune cells traffic (move) within the eye and also stimulates the immune system to reject corneal transplants--the most common type of transplantation performed. The researchers from the Schepens Eye Research Institute and the Massachusetts Eye and Ear Infirmary, both affiliates of Harvard Medical School, have also found that when this growth factor is blocked, corneal transplants survive. The study, published in the August issue of Nature Medicine, is the first to make a link between VEGEFR-3 and the body's immune response, and may hold significant promise not only for new treatments to prevent transplant rejection but also for diseases such as cancer that may proliferate because of VEGF-3.

"What we have discovered is a previously unknown connection or 'pathway' that stimulates the immune response in the eye and in other parts of the body," says Reza Dana, MD, MPH, a Senior Scientist at the Schepens Eye Research Institute, an Associate Professor and corneal specialist at the Massachusetts Eye and Ear Infirmary and Harvard Medical School, and the senior author of the study.

Each year, nearly 40 thousand Americans receive corneal transplants to replace injured or diseased corneas. Approximately 90 percent of corneal transplants are successful because the eye is intrinsically less likely to reject transplanted material than other parts of the body. However, to suppress rejection of corneal transplants, patients need to use steroid drops which can cause glaucoma, cataract development, and infection -- for years. Even then, many corneal transplants fail, and their failure can cause devastating vision loss. If transplants are placed in eyes suffering from inflammation (caused by a full-blown immune response to the original injury or disease), rej
'"/>

Contact: Patti Jacobs
pjacobs12@comcast.net
627-872-0364
Schepens Eye Research Institute
4-Aug-2004


Page: 1 2 3

Related biology news :

1. Protemix corporation announces discovery of way to repair hearts damaged by diabetes
2. New OHSU lab will speed drug discovery process
3. Genetic discovery could dramatically reduce need for liver transplants in children
4. Plant gene discovery could enhance plant growth, reduce fertilizer needs and phosphate pollution
5. Major scientific discovery in cancer research to be honored
6. New discovery could provide tool to detect whether a cancer will develop and spread
7. UNC research accelerates discovery of novel gene function
8. Tulane opens doors to discovery
9. U. Iowa muscular dystrophy discovery may lead to new treatment approaches
10. Fox Chase discovery may help physicians diagnose, treat devastating childhood disease
11. Maxygen subsidiary Verdia announces discovery and improvement of glyphosate tolerance gene

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/19/2020)... ... June 18, 2020 , ... ... series, “Automate Your Lab with Software for Data Decisions,” for pharmaceutical and ... how to integrate and automate cutting-edge scientific instruments and laboratory equipment from ...
(Date:6/11/2020)... ... June 08, 2020 , ... Cryo-Cell International’s ... measures to protect workers in the medical field. The face masks will be ... risk their lives every day to provide healthcare to pregnant women. The delivery ...
(Date:6/5/2020)... ... June 04, 2020 , ... “Although we are disappointed to ... of our attendees, staff, and the public. We remain committed to creating a ... to collaborate virtually,” said Julie Sutcliffe, President of WMIS. , The ...
Breaking Biology News(10 mins):
(Date:7/10/2020)... ... 09, 2020 , ... In most research using the zebrafish ... formation in zebrafish embryos, maintaining optical transparency to facilitate microscopic imaging. Over the ... using the zebrafish model to investigate the causes of leukaemia and its relationship ...
(Date:7/7/2020)... ... July 06, 2020 , ... Bio-IT ... Roche, Eli Lilly, Bristol-Myers Squibb, the University of Chicago, Massachusetts General Hospital, Mission: ... hosted an elite awards program, highlighting outstanding examples of how technology innovations and ...
(Date:7/1/2020)... ... June 30, 2020 , ... ... data insights, today announced that the launch of a new clinical ... data about the tumor microenvironment (TME). , “Flagship’s TissueInsight is a service ...
(Date:6/28/2020)... ... June 25, 2020 , ... Lumeda Inc. ... cancer, today announced the company has entered a license agreement with Roswell Park ... Lumeda globally exclusive rights to Roswell Park intellectual property surrounding a novel medical ...
Breaking Biology Technology:
Cached News: