HOME >> BIOLOGY >> NEWS
New discovery may help transplants survive

Boston, MA For the first time scientists have found that a growth factor called vascular endothelial growth factor receptor-3 (VEGFR-3), known to cause the growth of lymphatic vessels in the body, controls how immune cells traffic (move) within the eye and also stimulates the immune system to reject corneal transplants--the most common type of transplantation performed. The researchers from the Schepens Eye Research Institute and the Massachusetts Eye and Ear Infirmary, both affiliates of Harvard Medical School, have also found that when this growth factor is blocked, corneal transplants survive. The study, published in the August issue of Nature Medicine, is the first to make a link between VEGEFR-3 and the body's immune response, and may hold significant promise not only for new treatments to prevent transplant rejection but also for diseases such as cancer that may proliferate because of VEGF-3.

"What we have discovered is a previously unknown connection or 'pathway' that stimulates the immune response in the eye and in other parts of the body," says Reza Dana, MD, MPH, a Senior Scientist at the Schepens Eye Research Institute, an Associate Professor and corneal specialist at the Massachusetts Eye and Ear Infirmary and Harvard Medical School, and the senior author of the study.

Each year, nearly 40 thousand Americans receive corneal transplants to replace injured or diseased corneas. Approximately 90 percent of corneal transplants are successful because the eye is intrinsically less likely to reject transplanted material than other parts of the body. However, to suppress rejection of corneal transplants, patients need to use steroid drops which can cause glaucoma, cataract development, and infection -- for years. Even then, many corneal transplants fail, and their failure can cause devastating vision loss. If transplants are placed in eyes suffering from inflammation (caused by a full-blown immune response to the original injury or disease), rej
'"/>

Contact: Patti Jacobs
pjacobs12@comcast.net
627-872-0364
Schepens Eye Research Institute
4-Aug-2004


Page: 1 2 3

Related biology news :

1. Protemix corporation announces discovery of way to repair hearts damaged by diabetes
2. New OHSU lab will speed drug discovery process
3. Genetic discovery could dramatically reduce need for liver transplants in children
4. Plant gene discovery could enhance plant growth, reduce fertilizer needs and phosphate pollution
5. Major scientific discovery in cancer research to be honored
6. New discovery could provide tool to detect whether a cancer will develop and spread
7. UNC research accelerates discovery of novel gene function
8. Tulane opens doors to discovery
9. U. Iowa muscular dystrophy discovery may lead to new treatment approaches
10. Fox Chase discovery may help physicians diagnose, treat devastating childhood disease
11. Maxygen subsidiary Verdia announces discovery and improvement of glyphosate tolerance gene

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:11/27/2018)... ... November 27, 2018 , ... ... have worked together to integrate the LabArchives Classroom Edition with Current Protocols Essential ... will be available beginning January of 2019. , The integration of ...
(Date:11/20/2018)... (PRWEB) , ... November 19, 2018 , ... ... by Applications (academic research tools, drug development, agriculture, human clinical therapeutics, and animal ... breeding products), by Technology (drug compound and target screening, and agriculture and industrial ...
(Date:11/20/2018)... ... November 20, 2018 , ... Like many large breed dogs, Jack, a ... was a year old, his mom, Rebecca, noticed he was slow to get up ... veterinarian and her suspicions were confirmed: Jack had bilateral hip dysplasia, a congenital condition ...
Breaking Biology News(10 mins):
(Date:11/11/2018)... ... 09, 2018 , ... Triple W, an innovator of connected health devices, today ... for DFree ®, the first health tech wearable device for incontinence that monitors ... the bathroom. The announcement was made during CES Unveiled New York, an invite-only tech ...
(Date:11/7/2018)... , ... November 07, 2018 , ... ... been leading a campaign to increase awareness of the adult tissue stem cell ... the month of November, the company is intensifying this effort with new educational ...
(Date:11/5/2018)... ... November 05, 2018 , ... ... backed by Siemens Healthineers and several healthcare VC firms announces at Distributed Health ... making a history by purchasing tokens and obtaining its first radiology interpretations, one ...
(Date:11/3/2018)... ... ... Triangle Insights Group, a premier life sciences consulting firm, announced today that ... the United States, appearing on this year’s Inc. 5000 list. Since its inception ... over the previous three years. , Separately, Triangle Insights was also ranked on ...
Breaking Biology Technology:
Cached News: