New drug that enhances glutamate transmission in the brain being evaluated for...( an important protein FMRP. FMRP is b...)

New drug that enhances glutamate transmission in the brain being evaluated for fragile X

an important protein, FMRP. FMRP is believed to play an important role in allowing normal levels of AMPA receptor proteins to be made - in the absence of FMRP, AMPA receptors are decreased and show lower activity levels. The abnormal AMPA receptor activity is likely related to the abnormal connections seen between neurons in the brains of those with fragile X syndrome. Increasing the activity of AMPA receptors with an Ampakine may to some degree overcome the reduced number of AMPA receptors, with resulting improvements in brain connections in individuals with fragile X syndrome.

The design of the Phase II clinical study is a randomized double-blind placebo controlled trial lasting four weeks. Fifty patients from the Chicago area will be recruited for the study. It is anticipated that enrollment will occur over a two-year period. Outcome measures will include testing in four domains of attention and executive function; spatial and verbal/auditory memory; language; and behavior.

'"/>

Contact: John Pontarelli
jpontare@rush.edu
312-942-5949
Rush University Medical Center
28-Aug-2002

Page: 1 2 3
Related biology news :

1. Carnegie Mellon enhances Quantum Dot Corp. technology for long-term, live-animal imaging
2. Gene enhances prefrontal function at a price
3. Gene transfer enhances pair bonding in monogamous voles
4. Contract bridge enhances the immune system, according to a preliminary study by researchers at UC Berkeley
5. Vollum scientists find new form of dopamine transmission
6. New research supports theory that indirect transmission of chronic wasting disease
7. Inhibition of Borrelia burgdorferi protein may reduce Lyme disease transmission
8. Placental malaria increases mother-to-child HIV transmission
9. Study finds simple way to reduce HIV transmission from mom to baby
10. Wildlife markets and disease transmission
11. Researchers achieve germline transmission of gene knockdown in mice

Post Your Comments:

(Date:11/23/2009)...f Southern California biomedical engineer and card... tool to help clinicians distinguish cardiac emerg...oblems manageable with drugs and lifestyle change.... into the arteries feeding the heart, offer an ins...e blood vessels, often revealing deposits of a dan...

(Date:11/23/2009)...ch to classify the gender of six-week-old turkey p...g killed shortly after birth, according to Dr. Ger...ogy in Germany and his team. Their use of infrared...ds shows that it is a fast and accurate method wit...y to identify and select female eggs for breeding....

(Date:11/23/2009)...s are a nasty business, posing dangers to human he...versity is launching a new project with funding fr...that targets the fat and grease that contribute to...rban planners new tools to further reduce the risk... "sanitary" sewer systems, as opposed to "combined...

Breaking Biology News(10 mins):Stable plaque or heart attack plaque? USC researcher builds new sensor to tell which is which 2 Rescuing male turkey chicks 2 Lose the fat: Targeting grease to curtail sewer overflows 2 News media registration open for 20th World Diabetes Congress 50640 1 Scientists rebuild giant moa using ancient DNA 9093 1 Scientists rebuild giant moa using ancient DNA 9093 2 FDA Approves Multaq 28R 29 for Patients with Atrial Fibrillation or Atrial Flutter 50636 1 FDA Approves Multaq 28R 29 for Patients with Atrial Fibrillation or Atrial Flutter 50636 2 FDA Approves Multaq 28R 29 for Patients with Atrial Fibrillation or Atrial Flutter 50636 3 FDA Approves Multaq 28R 29 for Patients with Atrial Fibrillation or Atrial Flutter 50636 4 FDA Approves Multaq 28R 29 for Patients with Atrial Fibrillation or Atrial Flutter 50636 5 FDA Approves Multaq 28R 29 for Patients with Atrial Fibrillation or Atrial Flutter 50636 6 FDA Approves Multaq 28R 29 for Patients with Atrial Fibrillation or Atrial Flutter 50636 7

[0] Stable plaque or heart attack plaque? USC researcher builds new sensor to tell which is which [0] Rescuing male turkey chicks [0] Lose the fat: Targeting grease to curtail sewer overflows

(Date:11/19/2009)..., SEATTLE, Nov. 19 Om...unaudited financial results for the third quarter ...ed September 30, 2009, Omeros reported a net loss ...o a net loss of $7.4 million, or $2.54 per share, ...nded September 30, 2009, the Company reported a ne...

(Date:11/19/2009)..., NEW YORK, Nov. 19 N...hat it has sent the following letter to its shareh...ctober 30, 2009, of China Biopharmaceuticals Holdi... company based in the People,s Republic of China. ...t in Suzhou Eyre Pharmaceutical Co. Ltd., CHBP,s p...

(Date:11/19/2009)... , MUNSTER, Germany, November 19 /PRNewsw...have filed on November 16th, 2009 Flibanserin in t...dyskinesia in Parkinson,s,disease for orphan drug ...ncy,(EMEA). Levodopa-induced dyskinesia is a compl...inson,s and a serious burden to some of those,affe...

(Date:11/19/2009)... World,s Top Gene Synthesis Com...m (IGSC) to Coordinate Best Practices in Risk Redu...t of Worldwide Gene Synthesis Capacity , ...of the world’s leading gene synthesis compan... a common screening protocol to promote biosecurit...

Breaking Biology Technology:Omeros Corporation Reports Third Quarter 2009 Financial Results and Development Highlights 2 Omeros Corporation Reports Third Quarter 2009 Financial Results and Development Highlights 3 Omeros Corporation Reports Third Quarter 2009 Financial Results and Development Highlights 4 Omeros Corporation Reports Third Quarter 2009 Financial Results and Development Highlights 5 Omeros Corporation Reports Third Quarter 2009 Financial Results and Development Highlights 6 Omeros Corporation Reports Third Quarter 2009 Financial Results and Development Highlights 7 Omeros Corporation Reports Third Quarter 2009 Financial Results and Development Highlights 8 NeoStem Outlines to Shareholders Near-term and Long-term Business Strategies Following Acquisition of Chinese Pharmaceutical Company 2 NeoStem Outlines to Shareholders Near-term and Long-term Business Strategies Following Acquisition of Chinese Pharmaceutical Company 3 MONITORING FORCE GmbH Requests Acknowledgment of Flibanserin as "Orphan Drug" 2 World's Top Gene Synthesis Companies Establish Tough Biosecurity Screening Protocol 2 World's Top Gene Synthesis Companies Establish Tough Biosecurity Screening Protocol 3 World's Top Gene Synthesis Companies Establish Tough Biosecurity Screening Protocol 4

[0] Omeros Corporation Reports Third Quarter 2009 Financial Results and Development Highlights [0] NeoStem Outlines to Shareholders Near-term and Long-term Business Strategies Following Acquisition of Chinese Pharmaceutical Company [0] MONITORING FORCE GmbH Requests Acknowledgment of Flibanserin as "Orphan Drug"[0] World's Top Gene Synthesis Companies Establish Tough Biosecurity Screening Protocol

Other News:

...pers for breakfast, smoked salmon on.their bagels,...e news of a new.technique that could help to assu...ount of salt. Researchers at Eastern Oregon Univ...ers fish processors a safer and more economical wa...

...nfection. Johns Hopkins researchers have fo...s involuntary muscle contractions and bursts of wo...ction.. "We think antibodies made by the ... may go on to attack brain nerve cells in a subset...

...s Discovery of First Progesterone.Mimic To Act Sel...ith Reduced.Impact On Breast Cells .SAN DIEGO, Cal...nd).Pharmaceuticals Incorporated (Nasdaq: LGND) ha...otective activity in the uterus without concomitan...

... covered with scaly lesions,.cancerous growths--th...ou.Province in southwest China. Although these he...of impure coal, they are in reality the consequenc... energy needs, food preferences,.and cultural prac...

Now Chemistry Keeps Salty Taste Balanced In Smoked Fish 2 Brain Antibodies Provide New Clues To Origins Of Tourette's 2 Brain Antibodies Provide New Clues To Origins Of Tourette's 3 Ligand Scientists Discover Tissue-Selective Female Hormone Mimics 2 Ligand Scientists Discover Tissue-Selective Female Hormone Mimics 3 China And USGS--Working Together On Environmental Issues 2 China And USGS--Working Together On Environmental Issues 3

Now Chemistry Keeps Salty Taste Balanced In Smoked Fish Brain Antibodies Provide New Clues To Origins Of Tourette's Ligand Scientists Discover Tissue-Selective Female Hormone Mimics China And USGS--Working Together On Environmental Issues

...infectious diseases run in families because one in...s generally agree that an individual's genetic mak...o infectious disease, new findings from researcher... error in a single gene is enough to dramatically ...

...difference between a lifeless sack of chemicals an...ized, according to Stanford biophysical chemist St...rsity of California-Davis and Lawrence Livermore N...e cell membranes with unprecedented resolution-on ...

...l Institute of Mental Health has awarded Roel A. O...s at the David Geffen School of Medicine at UCLA, ...tudy of schizophrenia in collaboration with scient...cht in the Netherlands. ... Ophoff is also an ass...

...ash. -- Salmonella bacteria, infamous for food poi... infect by stealth. They slip unnoticed into and m... cells the body relies on to seek and destroy inva...ction by macrophages, turning predator cells to pr...

Inheriting a tendency to brain infection 2 Inheriting a tendency to brain infection 3 With record resolution and sensitivity, tool images how life organizes in a cell membrane 2 With record resolution and sensitivity, tool images how life organizes in a cell membrane 3 With record resolution and sensitivity, tool images how life organizes in a cell membrane 4 With record resolution and sensitivity, tool images how life organizes in a cell membrane 5 With record resolution and sensitivity, tool images how life organizes in a cell membrane 6 Genetic links to schizophrenia focus of international study 2 An infectious agent of deception, exposed through proteomics 2

Inheriting a tendency to brain infection With record resolution and sensitivity, tool images how life organizes in a cell membrane Genetic links to schizophrenia focus of international study An infectious agent of deception, exposed through proteomics