New evidence of effects of environmental factors on male fertility

The scientists, from INSERM in Rennes and Kremlin Bictre and the Hospital Italiano Garibaldi in Rosario, studied 225 men from the Litoral Sur region of Argentina - one of the world's most productive farming regions - who attended a first infertility consultation between 1995 and 1998.

The objective was to investigate the relationship between exposure to environmental agents and the seminal characteristics and serum hormone concentrations in men seeking fertility treatment. Information about lifestyle, occupation, medical history, the type of and extent of environmental exposure encountered by the men was collected via interviews, and a variety of physical and biological tests were carried out on 189 of the group.

The researchers report today in Human Reproduction* that they found that exposure to pesticides and solvents in particular was significantly associated with sperm threshold values well below the limit for male fertility.

They also found that men exposed to pesticides had higher concentrations of serum oestradiol than unexposed men and that men exposed to solvents had lower concentrations of luteinizing hormone. All the effects were greater in men with primary infertility (never had a child) than those with secondary infertility (infertile after having had a child).

Dr Luc Multigner from INSERM, said that the findings must be treated with caution because they involved a selected population and there were potential sources of bias within the study. Nevertheless, it had clearly demonstrated that in a population of men attending for infertility consultation, environmental exposure, particularly to pesticides and solvents, was associated with dramatic changes in seminal characteristics.

"Our results suggest that toxicants act on the testes and post-testicular sites, including the accessory sex glands," he said. "The testicles are one of the most vulnerable organs to environmental, physical and chemical agents. Exposure

Contact: Margaret Willson
European Society for Human Reproduction and Embryology

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