HOME >> BIOLOGY >> NEWS
New finding may identify unknown agents of mad-cow disease

Researchers at the University of Illinois at Chicago, working with yeast, have made the startling finding that the presence of one prion protein can spark the formation of other unrelated prions similar to the protein thought to cause mad cow and other diseases of mammals and man.

The researchers also devised a screening test that can be used to pinpoint unidentified prions, making it the first such genetic assay for these mysterious biological agents.

The findings are reported in the July 27 issue of the journal Cell by UIC biology professor Susan Liebman and three co-workers. A prion, the causative agent of "mad cow" disease and human Creutzfeldt-Jakob disease, is an improperly folded protein molecule that clumps together and corrupts other, healthy molecules of the same protein to do likewise, in domino fashion. When the cell divides, the corrupt protein is contained in both daughter cells, where it seeds the process again. Prions are thus infective and heritable without containing DNA or RNA as viruses do.

According to Liebman, the finding that one prion can help start the chain reaction in another, totally different protein is important, because much more is known about how prions propagate than about how they first appearwhich also bears on public health concerns. Most cases of Creutzfeldt-Jakob disease, a neurodegenerative disease in humans, have no known origin, she said.

Its a great concern that humans can acquire CJD from infected cattle, but far, far more cases arise spontaneously, Liebman said.

Liebmans team devised a genetic screen for a trait in yeast that sparked the appearance of a known yeast prion. Their test identified the protein responsible for this trait and also pointed to nine other yeast prion-like proteins causing the same trait. These new prion candidates were found to contain prion-like regions in their protein chains.

We think what we have is a general test for new prions, Liebman s
'"/>

Contact: Bill Burton
burton@uic.edu
312-996-2269
University of Illinois at Chicago
26-Jul-2001


Page: 1 2

Related biology news :

1. International study findings link acne-like rash to effectiveness of new targeted cancer treatment
2. Virginia Tech researchers to release findings on Smith River Project
3. New HIV findings
4. Stanford researchers findings may shed light on common, deadly birth defect
5. Briggs takes to the molecular level Darwins findings on plants sensing the direction of light
6. Brain serotonin enzyme finding might explain psychiatric disorders
7. Why does cloning create abnormalities? Scientists take a step towards finding out
8. TIGR president discusses significance of finding anthrax toxin
9. Latest findings on PCBs to be subject of June workshop at Illinois
10. Chlamydia in men now also linked to infertility new findings
11. Purdue scientists finding ways to outsmart crop-damaging bugs

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/22/2017)... , March 21, 2017   Neurotechnology , ... recognition technologies, today announced the release of the ... which provides improved facial recognition using up to ... a single computer. The new version uses deep ... accuracy, and it utilizes a Graphing Processing Unit ...
(Date:3/22/2017)... 2017 Vigilant Solutions , a vehicle ... agencies, announced today the appointment of retired FBI special ... safety business development. Mr. Sheridan brings more ... a focus on the aviation transportation sector, to his ... Mr. Sheridan served as the Aviation Liaison Agent Coordinator ...
(Date:3/20/2017)... , March 20, 2017 PMD Healthcare ... personal spirometer and Wellness Management System (WMS), a remote, ... Founded in 2010, PMD Healthcare is a Medical Device, ... a mission dedicated to creating innovative solutions that empower ... With that intent focus, PMD developed the first ever ...
Breaking Biology News(10 mins):
(Date:3/29/2017)... Research and Markets has announced the addition of the ... 2025" report to their offering. ... The Global Agricultural Chelates Market is poised ... decade to reach approximately $825.4 million by 2025. ... the given segments on global as well as regional levels presented ...
(Date:3/29/2017)... 29, 2017 The Global Microfluidic Chips Market ... a specialized and comprehensive study on the existing state of the ... , Europe and Asia-Pacific ... and Africa . ... Browse 172 Tables and Figures, 13 ...
(Date:3/28/2017)... Philadelphia, PA (PRWEB) , ... March 28, 2017 ... ... Johnston, spoke at a Marketing Roundtable on March 22 in Philadelphia. The event ... WHYY. , The Marketing Roundtable featured breakout groups and interaction ...
(Date:3/28/2017)... , March 28, 2017 Volition America, Inc., ... today announced the engagement of Deborah Vollmer Dahlke , ... strategic consultant. Dr. Vollmer Dahlke,s role will be ... in the State of Texas and ... Vollmer Dahlke has significant experience over the past ...
Breaking Biology Technology:
Cached News: