HOME >> BIOLOGY >> NEWS
New finding may identify unknown agents of mad-cow disease

Researchers at the University of Illinois at Chicago, working with yeast, have made the startling finding that the presence of one prion protein can spark the formation of other unrelated prions similar to the protein thought to cause mad cow and other diseases of mammals and man.

The researchers also devised a screening test that can be used to pinpoint unidentified prions, making it the first such genetic assay for these mysterious biological agents.

The findings are reported in the July 27 issue of the journal Cell by UIC biology professor Susan Liebman and three co-workers. A prion, the causative agent of "mad cow" disease and human Creutzfeldt-Jakob disease, is an improperly folded protein molecule that clumps together and corrupts other, healthy molecules of the same protein to do likewise, in domino fashion. When the cell divides, the corrupt protein is contained in both daughter cells, where it seeds the process again. Prions are thus infective and heritable without containing DNA or RNA as viruses do.

According to Liebman, the finding that one prion can help start the chain reaction in another, totally different protein is important, because much more is known about how prions propagate than about how they first appearwhich also bears on public health concerns. Most cases of Creutzfeldt-Jakob disease, a neurodegenerative disease in humans, have no known origin, she said.

Its a great concern that humans can acquire CJD from infected cattle, but far, far more cases arise spontaneously, Liebman said.

Liebmans team devised a genetic screen for a trait in yeast that sparked the appearance of a known yeast prion. Their test identified the protein responsible for this trait and also pointed to nine other yeast prion-like proteins causing the same trait. These new prion candidates were found to contain prion-like regions in their protein chains.

We think what we have is a general test for new prions, Liebman s
'"/>

Contact: Bill Burton
burton@uic.edu
312-996-2269
University of Illinois at Chicago
26-Jul-2001


Page: 1 2

Related biology news :

1. International study findings link acne-like rash to effectiveness of new targeted cancer treatment
2. Virginia Tech researchers to release findings on Smith River Project
3. New HIV findings
4. Stanford researchers findings may shed light on common, deadly birth defect
5. Briggs takes to the molecular level Darwins findings on plants sensing the direction of light
6. Brain serotonin enzyme finding might explain psychiatric disorders
7. Why does cloning create abnormalities? Scientists take a step towards finding out
8. TIGR president discusses significance of finding anthrax toxin
9. Latest findings on PCBs to be subject of June workshop at Illinois
10. Chlamydia in men now also linked to infertility new findings
11. Purdue scientists finding ways to outsmart crop-damaging bugs

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: New finding may identify unknown agents mad cow disease

(Date:10/30/2014)... bioengineering professor has received a $1.04 million grant ... cartilage tissue and reduce osteoarthritis using a patient,s ... microscaffolding made of biodegradable polymers., Liping Tang, a ... department, said the research is primarily focused on ... battlefield., "We,ve found that if we inject microscaffolding ...
(Date:10/30/2014)... Rochelle, NY, October 30, 2014—Oligonucleotide-based therapeutics present unique ... to cause reproductive and developmental harm. New consensus ... the combined chemical and biological characteristics of these ... Therapeutics , a peer-reviewed journal from Mary ... available free on the Nucleic Acid Therapeutics ...
(Date:10/30/2014)... New York | Heidelberg, 30 October 2014 Biological ... a better understanding of adsorption of solution ions ... biological cells. Now, a new study provides a ... and surrounding solution ions. Joanna Kotyńska and Zbigniew ... the authors of a study describing these findings, ...
Breaking Biology News(10 mins):UTA researcher uses microscaffolding injections to mend cartilage, prevent osteoarthritis 2New guidelines for reproductive & developmental toxicity testing of oligonucleotide drugs 2Ion adsorption matter in biology 2
(Date:10/30/2014)... Dallas, Texas (PRWEB) October 30, 2014 ... China Naltrexone HCL Industryā€¯ is a professional and ... The report provides basic Naltrexone HCL information, including ... as well as industry overview. This research covers ... as well as global industry analysis covering macroeconomic ...
(Date:10/30/2014)... Rancho BioSciences , the scientific ... curated public data source TCGA for several ... data is now available for other oncology groups. ... internal data sources for their Pharma, Government and academic ... data that becomes more easily accessible. Rancho advises ...
(Date:10/30/2014)... 2014 Whitehouse Laboratories has formally announced ... Testing and Package Test Capacity. Responding to growing demands ... dramatic increase in environmental chamber storage space that will ... aging samples to be securely held on site at ... expenditure has already taken place with the recent completion ...
(Date:10/30/2014)... Oct. 30, 2014 Isis Pharmaceuticals, Inc. (NASDAQ: ... that management will present a company overview at the Nomura ... ET in Boston, MA. ... the "Investors & Media" section of the Company,s website, ... website within 48 hours and will be archived for a ...
Breaking Biology Technology:Naltrexone HCL Market & Nalbuphine HCL Industry Analysis for Global, China Regions Now at DeepResearchReports.com 2Naltrexone HCL Market & Nalbuphine HCL Industry Analysis for Global, China Regions Now at DeepResearchReports.com 3Rancho BioSciences Manually Curated TCGA Data Sets Available 2Whitehouse Labs Announces Major Capital Investment in Stability and Storage Testing Capacity 2Whitehouse Labs Announces Major Capital Investment in Stability and Storage Testing Capacity 3Isis Pharmaceuticals to Present at the Nomura Biotechnology Conference 2
Cached News: