New finding may identify unknown agents of mad-cow disease

Researchers at the University of Illinois at Chicago, working with yeast, have made the startling finding that the presence of one prion protein can spark the formation of other unrelated prions similar to the protein thought to cause mad cow and other diseases of mammals and man.

The researchers also devised a screening test that can be used to pinpoint unidentified prions, making it the first such genetic assay for these mysterious biological agents.

The findings are reported in the July 27 issue of the journal Cell by UIC biology professor Susan Liebman and three co-workers. A prion, the causative agent of "mad cow" disease and human Creutzfeldt-Jakob disease, is an improperly folded protein molecule that clumps together and corrupts other, healthy molecules of the same protein to do likewise, in domino fashion. When the cell divides, the corrupt protein is contained in both daughter cells, where it seeds the process again. Prions are thus infective and heritable without containing DNA or RNA as viruses do.

According to Liebman, the finding that one prion can help start the chain reaction in another, totally different protein is important, because much more is known about how prions propagate than about how they first appearwhich also bears on public health concerns. Most cases of Creutzfeldt-Jakob disease, a neurodegenerative disease in humans, have no known origin, she said.

Its a great concern that humans can acquire CJD from infected cattle, but far, far more cases arise spontaneously, Liebman said.

Liebmans team devised a genetic screen for a trait in yeast that sparked the appearance of a known yeast prion. Their test identified the protein responsible for this trait and also pointed to nine other yeast prion-like proteins causing the same trait. These new prion candidates were found to contain prion-like regions in their protein chains.

We think what we have is a general test for new prions, Liebman s

Contact: Bill Burton
University of Illinois at Chicago

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