HOME >> BIOLOGY >> NEWS
New finding may identify unknown agents of mad-cow disease

Researchers at the University of Illinois at Chicago, working with yeast, have made the startling finding that the presence of one prion protein can spark the formation of other unrelated prions similar to the protein thought to cause mad cow and other diseases of mammals and man.

The researchers also devised a screening test that can be used to pinpoint unidentified prions, making it the first such genetic assay for these mysterious biological agents.

The findings are reported in the July 27 issue of the journal Cell by UIC biology professor Susan Liebman and three co-workers. A prion, the causative agent of "mad cow" disease and human Creutzfeldt-Jakob disease, is an improperly folded protein molecule that clumps together and corrupts other, healthy molecules of the same protein to do likewise, in domino fashion. When the cell divides, the corrupt protein is contained in both daughter cells, where it seeds the process again. Prions are thus infective and heritable without containing DNA or RNA as viruses do.

According to Liebman, the finding that one prion can help start the chain reaction in another, totally different protein is important, because much more is known about how prions propagate than about how they first appearwhich also bears on public health concerns. Most cases of Creutzfeldt-Jakob disease, a neurodegenerative disease in humans, have no known origin, she said.

Its a great concern that humans can acquire CJD from infected cattle, but far, far more cases arise spontaneously, Liebman said.

Liebmans team devised a genetic screen for a trait in yeast that sparked the appearance of a known yeast prion. Their test identified the protein responsible for this trait and also pointed to nine other yeast prion-like proteins causing the same trait. These new prion candidates were found to contain prion-like regions in their protein chains.

We think what we have is a general test for new prions, Liebman s
'"/>

Contact: Bill Burton
burton@uic.edu
312-996-2269
University of Illinois at Chicago
26-Jul-2001


Page: 1 2

Related biology news :

1. International study findings link acne-like rash to effectiveness of new targeted cancer treatment
2. Virginia Tech researchers to release findings on Smith River Project
3. New HIV findings
4. Stanford researchers findings may shed light on common, deadly birth defect
5. Briggs takes to the molecular level Darwins findings on plants sensing the direction of light
6. Brain serotonin enzyme finding might explain psychiatric disorders
7. Why does cloning create abnormalities? Scientists take a step towards finding out
8. TIGR president discusses significance of finding anthrax toxin
9. Latest findings on PCBs to be subject of June workshop at Illinois
10. Chlamydia in men now also linked to infertility new findings
11. Purdue scientists finding ways to outsmart crop-damaging bugs

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/22/2016)... 22, 2016   Acuant , the ... solutions, has partnered with RightCrowd ® ... Visitor Management, Self-Service Kiosks and Continuous Workforce ... add functional enhancements to existing physical access ... venues with an automated ID verification and ...
(Date:6/15/2016)... 15, 2016 Transparency Market ... Recognition Market by Application Market - Global Industry Analysis Size ... to the report, the  global gesture recognition market ... and is estimated to grow at a CAGR ... 2024.  Increasing application of gesture recognition ...
(Date:6/2/2016)... , June 2, 2016 The Department ... has awarded the 44 million US Dollar project, for the ... Vehicle Plates including Personalization, Enrolment, and IT Infrastructure , ... in the production and implementation of Identity Management Solutions. Numerous ... however Decatur was selected for the ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... , June 23, 2016 Houston ... with the Cy-Fair Sports Association to serve as ... the agreement, Houston Methodist Willowbrook will provide sponsorship ... and connectivity with association coaches, volunteers, athletes and ... with the Cy-Fair Sports Association and to bring ...
(Date:6/23/2016)... ... June 23, 2016 , ... Supplyframe, ... of the Supplyframe Design Lab . Located in Pasadena, Calif., the Design ... of how hardware projects are designed, built and brought to market. , The ...
(Date:6/23/2016)... June 23, 2016 ... 2016;12(1):22-8 http://doi.org/10.17925/OHR.2016.12.01.22 Published recently ... peer-reviewed journal from touchONCOLOGY, Andrew D Zelenetz ... of cancer care is placing an increasing burden ... expensive biologic therapies. With the patents on many ...
(Date:6/23/2016)... 22, 2016  Amgen (NASDAQ: AMGN ) ... QB3@953 life sciences incubator to accelerate the development ... laboratory space at QB3@953 was created to help high-potential ... for many early stage organizations - access to laboratory ... Amgen launched two "Amgen Golden Ticket" awards, providing each ...
Breaking Biology Technology:
Cached News: